International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

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International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Optimizing Neonatal Healthcare: A Comprehensive Study on Blood Transfusion Practices and Outcomes

Article Information

Volume / Issue6 / 1 (2025)
Pages49-54
AccessOpen Access

Publication Timeline

  • Received06 December 2024
  • Accepted09 January 2025

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Abstract

Introduction: Blood transfusion is a critical intervention in neonatal care, particularly for premature infants, to address complications such as anemia of prematurity and hemorrhagic shock. This study aimed to evaluate blood transfusion practices and outcomes in neonates at Kamenge Teaching Hospital, Burundi, addressing a gap in the literature specific to this region.

Materials and Methods: A prospective, observational study was conducted from January to August 2024, including 48 newborns who met the eligibility criteria and underwent blood transfusion. Data were collected using pre-established forms and analyzed using Microsoft Word 2010 for text entry, and Excel 2010 and SPSS version 25 for data analysis and processing. The study was approved by the Ethics Committee of Kamenge Teaching Hospital, and informed consent was obtained from the parents or legal guardians of each participant.

Results: The study found a higher proportion of female newborns (54.2%) and those from rural areas (64.6%). Prematurity was the leading cause for hospitalization (42.7%), and the majority had moderate anemia (62.5%). The majority of transfusions were well-tolerated, with a low incidence of transfusion-related accidents (6.3%). Favorable clinical evolution was observed in 83.3% of cases, while the mortality rate was 16.7%.

Conclusion: The study underscores the critical need for optimizing blood transfusion practices and neonatal care in Burundi. Recommendations include reviewing transfusion protocols, strengthening management measures for preterm infants, expanding preventive health measures in rural areas, and investing in the training and education of healthcare providers. The study also highlights the importance of ongoing monitoring and further research to improve neonatal health outcomes in low-resource settings.

References

  1. Jeon GW, Sin JB. Risk factors of transfusion in anemia of very low birth weight infants. Yonsei Medical Journal. 2013;54(2):366–373. [Google Scholar][Crossref]
  2. Strauss RG. Anaemia of prematurity: pathophysiology and treatment. Blood Reviews. 2010;24(6):221–225. [Google Scholar][Crossref]
  3. Flores CJ, Jones L, Martin R, et al. Embedding best transfusion practice and blood management in neonatal intensive care. BMJ Open Quality. 2020;9(1):e001103. [Google Scholar][Crossref]
  4. Shafique MA, Hussain R, Ahmad R, et al. Transfusion strategies for neonates: current perspectives. Annals of Medicine and Surgery (London). 2024;86(3):1550– 1562. [Google Scholar][Crossref]
  5. Murray NA, Roberts IA. Neonatal transfusion practice. Archives of Disease in Childhood: Fetal and Neonatal Edition. 2004;89(2):F101–F107. [Google Scholar][Crossref]
  6. Zerra PE, Josephson CD. Transfusion in neonatal patients: review of evidence-based guidelines. Clinics in Laboratory Medicine. 2021;41(1):15–34. [Google Scholar][Crossref]
  7. Mili FD, Prokop C, Lyerly H, et al. New HIV infections from blood transfusions averted in 28 countries supported by PEPFAR blood safety programs, 2004– 2015. Transfusion. 2021;61(3):851–861. [Google Scholar][Crossref]
  8. MacDonald NE, Baker T, Bhutta ZA, et al. Transfusion and risk of infection in Canada: update 2012. Paediatrics & Child Health. 2012;17(10):e102–e111. [Google Scholar][Crossref]
  9. Dollat C, Mercier P, Chambon P, et al. Single-donor protocol: transfusion practices and multiple transfusion risk factors in neonatal intensive care unit. Archives de Pédiatrie. 2016;23(9):935–943. [Google Scholar][Crossref]
  10. Arora S, Mehta R, Sharma K, et al. Dedicated donor unit transfusions reduce donor exposure in pediatric surgery patients. Asian Journal of Transfusion Science. 2017;11(2):124–130. [Google Scholar][Crossref]
  11. Zhang M, Wang H, Li Y, et al. Intensive phototherapy vs. exchange transfusion for the treatment of neonatal hyperbilirubinemia: a multicenter retrospective cohort study. Chinese Medical Journal (English). 2022;135(5):598–605. [Google Scholar][Crossref]
  12. Girelli G, Serafini M, Montanari L, et al. Recommendations for transfusion therapy in neonatology. Blood Transfusion. 2015;13(3):484–497. [Google Scholar][Crossref]
  13. Patel RM, Shankaran S, Bell EF, et al. Variation in neonatal transfusion practice. The Journal of Pediatrics. 2021;235:92–99.e4. [Google Scholar][Crossref]
  14. Berry MA, Stevens TP, Ramanathan R, et al. Predictors of mortality and length of stay for neonates admitted to children's hospital neonatal intensive care units. Journal of Perinatology. 2008;28(4):297–302. [Google Scholar][Crossref]
  15. Pierrat V, Marchand-Martin L, Arnaud C, et al. Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks' gestation in France in 2011: EPIPAGE-2 cohort study. BMJ. 2017;358:j3448. [Google Scholar][Crossref]
  16. Stoll BJ, Hansen NI, Bell EF, et al. Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993–2012. JAMA. 2015;314(10):1039–1051. [Google Scholar][Crossref]

How to Cite

Nzambimana, D., Nsanzabagenzi, D., Barenzako, L., Ndayisenga, P., Vyamungu, A. M., & Ntawuyamara, E. (2025). Optimizing Neonatal Healthcare: A Comprehensive Study on Blood Transfusion Practices and Outcomes. International Journal of Medical and All Body Health Research, 6(1), 49-54. https://doi.org/10.54660/IJMBHR.2025.6.1.49-54

Nzambimana, David, et al. "Optimizing Neonatal Healthcare: A Comprehensive Study on Blood Transfusion Practices and Outcomes." International Journal of Medical and All Body Health Research, vol. 6, no. 1, 2025, pp. 49-54. https://doi.org/10.54660/IJMBHR.2025.6.1.49-54.

Nzambimana, D., Nsanzabagenzi, D., Barenzako, L., Ndayisenga, P., Vyamungu, A. M. and Ntawuyamara, E. (2025) 'Optimizing Neonatal Healthcare: A Comprehensive Study on Blood Transfusion Practices and Outcomes', International Journal of Medical and All Body Health Research, 6(1), pp. 49-54. doi: 10.54660/IJMBHR.2025.6.1.49-54.

Nzambimana D, Nsanzabagenzi D, Barenzako L, Ndayisenga P, Vyamungu AM, Ntawuyamara E. Optimizing Neonatal Healthcare: A Comprehensive Study on Blood Transfusion Practices and Outcomes. International Journal of Medical and All Body Health Research. 2025;6(1):49-54. doi:10.54660/IJMBHR.2025.6.1.49-54

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