Classification, Importance, and Pathogenicity of Facklamia Species and Related Bacteria
Article Information
Publication Timeline
- Received10 November 2024
- Accepted12 December 2024
Abstract
Facklamia is a genus of Gram-positive, facultatively anaerobic cocci, first identified in 1997. These bacteria are part of the family Aerococcaceae, closely related to other lactic acid bacteria in the order Lactobacillales. The genus currently includes species like Facklamia hominis, Facklamia ignava, and Facklamia languida, which are often found in human clinical samples including blood, cerebrospinal fluid, and wounds. While typically harmless in healthy individuals, Facklamia infections can lead to serious complications in immunocompromised patients or those with underlying conditions and are implicated in infections such as bacteremia, paendocarditis, and chorioamnionitis. The recognition of Facklamia in clinical settings has grown, necessitating more research into their epidemiology and significance. Facklamia species are catalase-negative and typically form small chains or clusters. Accurate identification of these bacteria is critical due to their close resemblance to other cocci, such as Streptococci, under a microscope. The pathogenic mechanisms of Facklamia are not fully understood, but they are increasingly associated with nosocomial infections, particularly in vulnerable patient populations. Accurate diagnostic methods and awareness of Facklamia's pathogenic potential are critical for effective treatment.
References
- (2022). Facklamia hominis pyelonephritis in a pediatric patient: first case report and review of the literature. Annals of Clinical Microbiology and Antimicrobials. 21(1):4. Available from: springer.com [Google Scholar][Crossref]
- Ait Tamlihat Y, Violette J, Labrousse J, Bregeaud D, Vincent JF. Identification of Facklamia hominis in a case of stercoral peritonitis. A case report and review of the literature. Infectious Diseases Diagnosis and Treatment. 2020;4(138):2515–77. Available from: academia.edu [Google Scholar][Crossref]
- Al-Shamiri MM, Zhang S, Mi P, Liu Y, Xun M, Yang E, et al. Phenotypic and genotypic characteristics of Acinetobacter baumannii enrolled in the relationship between antibiotic resistance, biofilm formation, and motility. Microbial Pathogenesis. 2021;155:104922. Available from: sciencedirect.com [Google Scholar][Crossref]
- Ashour DS, Othman AA. Parasite –bacteria interrelationship. Parasitology Research. 2020. [HTML] [Google Scholar][Crossref]
- Bastos MMF, Maran BM, Maran EM, Miotto-Lindner M, Verruck S. Assessment of microbial ecology in artisanal salami during maturation via metataxonomic analysis. Food Science and Technology. 2024;44. Available from: emnuvens.com.br [Google Scholar][Crossref]
- Chen H, Zhang J, He Y, Lv Z, Liang Z, Chen J, et al. Exploring the role of Staphylococcus aureus in inflammatory diseases. Toxins. 2022;14(7):464. Available from: mdpi.com [Google Scholar][Crossref]
- Cheung GYC, Bae JS, Otto M. Pathogenicity and virulence of Staphylococcus aureus. Virulence. 2021. Available from: tandfonline.com [Google Scholar][Crossref]
- Chmielarczyk A, Pomorska -Wesołowska M, Romaniszyn D, Workowski-Mach J. Healthcare-associated laboratory-confirmed bloodstream infections—species diversity and resistance mechanisms, a four-year retrospective laboratory-based study in the South of Poland. International Journal of Environmental Research and Public Health. 2021;18(5):2785. Available from: mdpi.com [Google Scholar][Crossref]
- Church DL, Cerutti L, Gürtler A, Griener T, Zelazny A, Emler S. Performance and application of 16S rRNA gene cycle sequencing for routine identification of bacteria in the clinical microbiology laboratory. Clinical Microbiology Reviews. 2020;33(4):10–1128. Available from: nih.gov [Google Scholar][Crossref]
- Coelho MC, Malcata FX, Silva CCG. Lactic acid bacteria in raw milk cheeses: From starter cultures to probiotic functions. Foods. 2022. Available from: mdpi.com [Google Scholar][Crossref]
- Desjardin DE, Perry BA. Fungi of São Tomé and Príncipe Islands: basidiomycete mushrooms and allies. Biodiversity of the Gulf of Guinea Oceanic Islands: Science and Conservation. 2022. Springer, Cham; p. 189–216. Available from: oapen.org [Google Scholar][Crossref]
- Doll EV, Staib L, Huptas C, Scherer S, Wenning M. Facklamia lactis sp. nov., isolated from raw milk. International Journal of Systematic and Evolutionary Microbiology. 2021;71(7):004869. [HTML] [Google Scholar][Crossref]
- Dorant Y, Cayuela H, Wellband K, Laporte M, Rougemont Q, Mérot C, et al. Copy number variants outperform SNPs to reveal genotype–temperature association in a marine species. Molecular Ecology. 2020;29(24):4765–82. Available from: biorxiv.org [Google Scholar][Crossref]
- dos Anjos Borges LG, Pastuschek J, Heimann Y, Dawczynski K, PEONS study group, et al. Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early-onset neonatal sepsis. BMC Medicine. 2023;21(1):92. Available from: springer.com [Google Scholar][Crossref]
- Fotedar R, Chatting M, Kolecka A, Zeyara A, Al Malki A, Kaul R, et al. Communities of culturable yeasts and yeast-like fungi in oligotrophic hypersaline coastal waters of the Arabian Gulf surrounding Qatar. Antonie van Leeuwenhoek. 2022;115(5):609–33. Available from: researchgate.net [Google Scholar][Crossref]
- Fotedar R, Sankaranarayanan K, Caldwell ME, Zeyara A, Al Malki A, Kaul R, et al. Reclassification of Facklamia ignava, Facklamia sourekii and Facklamia tabacinasalis as Falseniella ignava gen. nov., comb. nov., Hutsoniella sourekii gen. nov., comb. nov., and Ruoffia International Journal of Medical and All Body Health Research www.allmedicaljournal.com tabacinasalis gen. nov., comb. nov., and description of Ruoffia halotolerans sp. nov., isolated from hypersaline Inland Sea of Qatar. Antonie van Leeuwenhoek. 2021;114:1181–93. [HTML] [Google Scholar][Crossref]
- Frias-De-Leon MG, Pinto-Almazan R, Hernandez-Castro R, Garcia-Salazar E, Meza-Meneses P, Rodriguez-Cerdeira C, et al. Epidemiology of systemic mycoses in the COVID-19 pandemic. Journal of Fungi. 2021;7(7):556. Available from: mdpi.com [Google Scholar][Crossref]
- Fulton S. Heirloom Microbes: A survey of lactic acid bacteria in traditional Mongolian dairy. 2020. Available from: shareok.org [Google Scholar][Crossref]
- Gahl M, Stöckli T, Fahrner R. Facklamia hominis bacteremia after transurethral resection of the prostate: a case report. BMC Urology. 2020. Available from: springer.com [Google Scholar][Crossref]
- Hoque MN, Istiaq A, Rahman MS, Islam MR, Anwar A, Siddiki AZ, et al. Microbiome dynamics and genomic determinants of bovine mastitis. Genomics. 2020;112(6):5188–203. Av ailable from: sciencedirect.com [Google Scholar][Crossref]
- Kadri Z, Spitaels F, Cnockaert M, Amar M, Joossens M, Vandamme P. The bacterial diversity of raw Moroccan camel milk. International Journal of Food Microbiology. 2021;341:109050. [HTML] [Google Scholar][Crossref]
- Kumar S, Yadav M, Sehrawat N, Devi T, Sharma AK, Lodhi MM. Assessment of bacterial diversity in the chicken litter: A potent risk to environmental health. Academia.edu. 2022. [Google Scholar][Crossref]
- Kuryłek A, Stasiak M, Kern-Zdanowicz I. Virulence factors of Streptococcus anginosus – a molecular perspective. Frontiers in Microbiology. 2022. Available from: frontiersin.org. [Google Scholar][Crossref]
- Lianou A, Nychas GJE, Koutsoumanis KP. Strain variability in biofilm formation: A food safety and quality perspective. Food Research International. 2020. [HTML] [Google Scholar][Crossref]
- Liou JS, Huang CH, Ikeyama N, Lee AY, Chen IC, Blom J, et al. Prevotella hominis sp. nov., isolated from human feces. International Journal of Systematic and Evolutionary Microbiology. 2020;70(8):4767-73. [HTML] [Google Scholar][Crossref]
- Mahittikorn A, Udonsom R, Koompapong K, Chiabchalard R, Sutthikornchai C, Sreepian PM, et al. Molecular identification of Pentatrichomonas hominis in animals in central and western Thailand. BMC Veterinary Research. 2021;17(1):203. Available from: springer.com. [Google Scholar][Crossref]
- Moreland RB, Choi BI, Geaman W, Gonzalez C, Hochstedler-Kramer BR, John J, et al. Beyond the usual suspects: emerging uropathogens in the microbiome age. Frontiers in Urology. 2023;3:1212590. Available from: frontiersin.org. [Google Scholar][Crossref]
- Munson E, Carroll KC. Update on accepted novel bacterial isolates derived from human clinical specimens and taxonomic revisions published in 2020 and 2021. Journal of Clinical Microbiology. 2023. Available from: asm.org. [Google Scholar][Crossref]
- Omotoso AO, Reyer H, Oster M, Ponsuksili S, Wimmers K. Jejunal microbiota of broilers fed varying levels of mineral phosphorus. Poultry Sci ence. 2023;102(12):103096. Available from: sciencedirect.com. [Google Scholar][Crossref]
- Pilarczyk-Zurek M, Sitkiewicz I, Koziel J. The clinical view on Streptococcus anginosus group – opportunistic pathogens coming out of hiding. Frontiers in Microbiology. 2022. Available from: frontiersin.org. [Google Scholar][Crossref]
- Pinto IMO. Using state-of-the-art technologies to characterize the seminal microbiome. Up.pt. 2022. [Google Scholar][Crossref]
- Rahmati E, Martin V, Wong D, Sattler F, Jonas P, Ward P, et al. Facklamia species as a recognized pathogen. Open Forum Infectious Diseases. 2016. [Google Scholar][Crossref]
- Rashmi F, Krithivasan S, Caldwell ME, Aisha Z, Ridhima K, Ali M, et al. Reclassification of Facklamia ignava, Facklamia sourekii and Facklamia tabacinasalis as Falseniella ignava gen. nov., comb. nov., Hutsoniella sourekii gen. nov., comb. nov., and Ruoffia tabacinasalis gen. nov., comb. nov., and description of Ruoffia halotolerans sp. nov., isolated from hypersaline Inland Sea of Qatar. Antonie van Leeuwenhoek. 2021;114(8):1181-93. [HTML] [Google Scholar][Crossref]
- Reydams H, Wuytack A, Piepers S, Mertens K, Boyen F, de Souza FN, et al. Genetic diversity and iron metabolism of Staphylococcus hominis isolates originating from bovine quarter milk, rectal feces, and teat apices. Journal of Dairy Science. 2022;105(12):9995-10006. Available from: sciencedirect.com. [Google Scholar][Crossref]
- Rosales-Castillo A, Expósito-Ruiz M, Gutiérrez-Soto M, Navarro-Marí JM, Gutiérrez-Fernández J. Presence and relevance of emerging microorganisms in clinical genitourinary samples. Microorganisms. 2023;11(4):915. Available from: mdpi.com. [Google Scholar][Crossref]
- Rossi F, Santonicola S, Amadoro C, Marino L, Colavita G. Recent records on bacterial opportunistic infections via the dietary route. Microorganisms. 2023;12(1):69. Available from: mdpi.com. [Google Scholar][Crossref]
- Royer‐Tardif S, Boisvert‐Marsh L, Godbout J, Isabel N, Aubin I. Finding common ground: Toward comparable indicators of adaptive capacity of tree species to a changing climate. Ecology and Evolution. 2021;11(19):13081-97. Available from: wiley.com. [Google Scholar][Crossref]
- Russell L, Whyte P, Zintl A, Gordon SV, Markey B, de Waal T, et al. When applied to grass in slurry and digest. Frontiers in Sustainable Food Systems. 2022;6:806920. Available from: frontiersin.org. [Google Scholar][Crossref]
- Sauer K, Stoodley P, Goeres DM, Hall-Stoodley L, Burmølle M, Stewart PS, et al. The biofilm life cycle: expanding the conceptual model of biofilm formation. Nature Reviews Microbiology. 2022;20(10):608-20. Available from: nih.gov. [Google Scholar][Crossref]
- Schlattmann A, von Lützau K, Kaspar U, Becker K. The porcine nasal microbiota with particular attention to livestock-associated methicillin -resistant Staphylococcus aureus in Germany—A culturomic approach. Microorganisms. 2020. Available from: mdpi.com. [Google Scholar][Crossref]
How to Cite
Mahmood, H. A. R., & Abdullah, B. A. (2025). Classification, Importance, and Pathogenicity of Facklamia Species and Related Bacteria. International Journal of Medical and All Body Health Research, 6(1), 16-23. https://doi.org/10.54660/IJMBHR.2025.6.1.16-23
Mahmood, Haddad-Aamer Rajab, and Basima A Abdullah. "Classification, Importance, and Pathogenicity of Facklamia Species and Related Bacteria." International Journal of Medical and All Body Health Research, vol. 6, no. 1, 2025, pp. 16-23. https://doi.org/10.54660/IJMBHR.2025.6.1.16-23.
Mahmood, H. A. R. and Abdullah, B. A. (2025) 'Classification, Importance, and Pathogenicity of Facklamia Species and Related Bacteria', International Journal of Medical and All Body Health Research, 6(1), pp. 16-23. doi: 10.54660/IJMBHR.2025.6.1.16-23.
Mahmood HAR, Abdullah BA. Classification, Importance, and Pathogenicity of Facklamia Species and Related Bacteria. International Journal of Medical and All Body Health Research. 2025;6(1):16-23. doi:10.54660/IJMBHR.2025.6.1.16-23
Similar Articles
- Comparison of Elective Cesarean Section and Vaginal Delivery Outcomes: A Study of 100 Patients at Saraswathi Institute of Medical Sciences Vol 6, Issue 1 (2025)
- Knowledge and Attitudes towards Sexually Transmitted Infections among Medical Groups and Non-Medical Colleges at Baghdad University 2024 Vol 6, Issue 1 (2025)
- Deep Learning-Based Real-Time Data Quality Assessment and Anomaly Detection for Large-Scale Distributed Data Streams Vol 6, Issue 1 (2025)
- Pathogenesis and Therapeutic Targets of Cytokine Storms in Bacterial Infections Vol 6, Issue 1 (2025)
- Response Analysis of Teens towards Mentally Ill Patients Vol 6, Issue 1 (2025)
Find this Article on
Google Scholar Semantic Scholar OpenAlex Scilit Crossref ResearchGate BASEA newly published article may take a few days to appear on these services.