International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

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International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Formulation and evaluation of Pregabalin microspheres

Y Ganesh Kumar, Sirpangi Radhika, Md. Kamarujjaman, Pradepta Prasad Barooh, Lakkam Anusha

Professor, Department of Pharmacognosy & Phytochemistry, Sree Dattha Institute of Pharmacy Sheriguda (V), Ibrahimpatnam(M) Ranga Reddy, Telangana, India; Department of Pharmaceutical Analysis, Sree Dattha Institute of Pharmacy, Sagar Road, Sheriguda, Ibrahimpatnam, Telangana, India

Article Information

Volume / Issue5 / 1 (January-March 2024)
Pages49-52
AccessOpen Access

Publication Timeline

  • Received05 February 2024
  • Accepted10 March 2024

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Abstract

Microspheres play a very important role as particulate drug delivery system because of their small size and other efficient properties. Microspheres are characteristically free flowing solid powders, which consist of proteins or synthetic polymer, which are biodegradable in nature. The present study aimed to formulate and evaluate Pregabal in microspheres. Ionotropic gelation technique was employed for microsphere preparation using different ratios of ethyl cellulose polymer and drug. Prepared microspheres were evaluated for drug entrapment efficiency, micromeritic characters and In vitro drug release. The particle size of all the formulations were ranged between 152.2 to 142.9 µm. The entrapment efficiency was ranged between 78.95 to 82.14 %. Stability studies showed almost negligible changes in particle size, entrapment efficiency and drug release throughout the study period. 

Keywords

PregabalinFTIR studiesSodium alginateIonotropic gelation techniqueIn vitro drug release studies

References

  1. Benoit R, Marchais H, Rolland H, van Velde VV. Biodegradable microspheres, advances in production technology. In: Benita S, editor. Microencapsulation: Methods and Industrial Applications. Vol. 73. New York: Marcel Dekker; 1996. p. 35–72. [Google Scholar][Crossref]
  2. Benita S, Benoit JP, Puieux F, Thies C. Characterization of drug-loaded poly (D,L-lactide) microspheres. Journal of Pharmaceutical Sciences. 1984;73:1721–4. [Google Scholar][Crossref]
  3. Jain SK, Rai G, Saraf DK, Agrawal GP. The preparation and evaluation of albendazole microspheres for colonic delivery. Pharmaceutical Technology; c2004. [Google Scholar][Crossref]
  4. Das MK, Senapathi PC. Furosemide-loaded alginate microspheres prepared by ionic cross-linking technique: morphology and release characteristics. Indian Journal of Pharmaceutical Sciences; c2008. [Google Scholar][Crossref]
  5. Das MK, Rama Rao K. Microencapsula tion of zidovudine by double emulsion solvent technique using ethylcellulose. Indian Journal of Pharmaceutical Sciences; c2007. [Google Scholar][Crossref]
  6. Vaghani S, Vasanti S, Chaturvedi K, Satish CS, Shankar SJ. Formulation and evaluation of 5-FU loaded Eudragit microspheres: effect of various Eudragit types on micromeritic properties of microspheres. Journal of Macromolecular Science, Part A: Pure and Applied Chemistry. 2008;45:1015–27. [Google Scholar][Crossref]
  7. Jain SK, Rai G, Saraf DK, Agrawal GP. The preparation and evaluation of albendazole microspheres for colonic delivery. Pharmaceutical Technology; c2004. [Google Scholar][Crossref]
  8. Kılıçarslan M, Baykara T. The effect of the drug/polymer ratio on the properties of verapamil HCl-loaded microspheres. International Journal of Pharmaceutics. 2003;252:99–109. [Google Scholar][Crossref]
  9. Jones DS, Pearce KJ. Contribution of process variables to the entrapment efficiency of propranolol hydrochloride within ethylcellulose microspheres prepared by the solvent evaporation method as evaluated using a factorial design. International Journal of Pharmaceutics. 1996;131:25–31. Copyright and License © The Author(s). Authors retain the copyright of their published articles. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution Non Commercial-Share A like 4.0 International (CC BY-NC-SA 4.0) License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. [Google Scholar][Crossref]

How to Cite

Kumar, Y. G., Radhika, S., Kamarujjaman, M., Barooh, P. P., & Anusha, L. (2024). Formulation and evaluation of Pregabalin microspheres. International Journal of Medical and All Body Health Research, 5(1), 49-52.

Kumar, Y Ganesh, et al. "Formulation and evaluation of Pregabalin microspheres." International Journal of Medical and All Body Health Research, vol. 5, no. 1, 2024, pp. 49-52.

Kumar, Y. G., Radhika, S., Kamarujjaman, M., Barooh, P. P. and Anusha, L. (2024) 'Formulation and evaluation of Pregabalin microspheres', International Journal of Medical and All Body Health Research, 5(1), pp. 49-52.

Kumar YG, Radhika S, Kamarujjaman M, Barooh PP, Anusha L. Formulation and evaluation of Pregabalin microspheres. International Journal of Medical and All Body Health Research. 2024;5(1):49-52.

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