International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

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     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Prevalence of cytomegalovirus in new and recurrent ulcerative colitis

Farzad Mahshad, Mohsen Masoodi, Mohammad Sabzikarian, Marjan Mokhtare, Ali Salimi-Jeda, Behnaz Bouzari, Mohammad Hadi Karbalaie Niya

Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Virology, Iran University of Medical Sciences, Tehran, Iran; Department of Pathology, Iran University of Medical Sciences, Tehran, Iran; Department of Virology, Iran University of Medical Sciences, Tehran, Iran Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran

Article Information

Volume / Issue4 / 3 (July-September 2023)
Pages01-05
AccessOpen Access

Publication Timeline

  • Received20 May 2023
  • Accepted02 June 2023

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Abstract

Background: Identification of risk factors for exacerbation of ulcerative colitis (UC) can be helpful in the prevention and treatment of it. This study aimed to evaluate the epidemioclinical features of the patients with cytomegalovirus ulcerative colitis.
Methods: In this cross-sectional study, patients with UC referred to the gastrointestinal ward of Rasool-e Akram and Firoozgar hospitals were selected. After pharmaceutical treatment of ulcerative colitis, both newly diagnosed patients for colitis and patients who did not respond to treatment and returned to the hospital, Underwent colonoscopy, a colon biopsy was performed and a blood sample was taken for active cytomegalovirus (CMV) by ELISA. Tissue samples were examined by PCR.
Results: A total of 72 patients with ulcerative colitis (65 recurrent patients) were included in the study. In total patients with colitis, based on serological results, 11.1% of the patients had acute infection and 88.9% had CMV infection in the past, but based on the detection of CMV using PCR, the virus genome was revealed only in 2.8%. In general, the highest rate of CMV tracking was related to cases of pancolitis and the lowest rate was related to proctitis. The rate of CMV was not affected by other variables such as gender, age or Anti-colitis drug protocol. 
Conclusion: The rate of CMV infection in patients with ulcerative colitis is directly related to the extent and severity of the disease but may not be affected by the treatment protocol. 
 

Keywords

Cytomegalovirusulcerative colitisinflammatory bowel disease

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How to Cite

Mahshad, F., Masoodi, M., Sabzikarian, M., Mokhtare, M., Salimi-Jeda, A., Bouzari, B., & Niya, M. H. K. (2023). Prevalence of cytomegalovirus in new and recurrent ulcerative colitis. International Journal of Medical and All Body Health Research, 4(3), 01-05.

Mahshad, Farzad, et al. "Prevalence of cytomegalovirus in new and recurrent ulcerative colitis." International Journal of Medical and All Body Health Research, vol. 4, no. 3, 2023, pp. 01-05.

Mahshad, F., Masoodi, M., Sabzikarian, M., Mokhtare, M., Salimi-Jeda, A., Bouzari, B. and Niya, M. H. K. (2023) 'Prevalence of cytomegalovirus in new and recurrent ulcerative colitis', International Journal of Medical and All Body Health Research, 4(3), pp. 01-05.

Mahshad F, Masoodi M, Sabzikarian M, Mokhtare M, Salimi-Jeda A, Bouzari B, et al. Prevalence of cytomegalovirus in new and recurrent ulcerative colitis. International Journal of Medical and All Body Health Research. 2023;4(3):01-05.

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