International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

Current Issues
     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Toxicity of Chinaberry Leaf Purified Extract (Melia azedarach L.) and Creekpremna Leaf (Premna serratifolia L.) to Aedes aegypti L Larval Mortality

Dwi Wahyuni, Joko Waluyo, Rachmita Mustika Putri, Ulmiyatul Alifiah Zahroh

Department of Biology Education, University of Jember, Indonesia

Article Information

Volume / Issue4 / 3 (2023)
Pages17-23
AccessOpen Access

Publication Timeline

  • Received05 July 2023
  • Accepted23 July 2023

Full Text (PDF)

Open Access - Free to Download

Download Full Article (PDF) JATS XML

Abstract

Aedes aegypti L. is a vector of dengue fever. One of the efforts to eradicate dengue fever is by controlling the disease vector. The use of natural larvicides that are environmentally friendly is an option to replace chemical insecticides that have negative impacts on the environment. The aim of this study was to compare the toxicity of purified extracts of Melia azedarach L. (Mindi) and Premna serratifolia L. (Daun Buas-Buas) on the mortality of Aedes aegypti L. mosquito larvae. The sample used in this study ranged from 600-700 Aedes aegypti L. mosquito larvae in each extract. The study used a completely randomized design (CRD) and the Minitab 14 for Windows application to perform the analysis. The results of the study showed that the toxicity of purified extracts of Melia azedarach L. (Mindi) and Premna serratifolia L. (Daun Buas-Buas) on the mortality of Aedes aegypti L. mosquito larvae was different. The LC50 value for purified extract of Melia azedarach L. was higher at 1265.93 ppm, while the LC50 value for purified extract of Premna serratifolia L. was lower at 1635.49 ppm

 

Keywords

Toxicity of Chinaberry LeafMelia azedarach LCreekpremna LeafAedes aegypti L Larval Mortality

References

  1. Ahdiyah I. Pengaruh Ekstrak Daun Mangkokan (Nothopanax scutellarium) Sebagai The Influence Of (Nothopanax scutellarium) Leaf Extracts As Larvicidies For Mosquito Culex sp. Skripsi. 2015; 4(2):2337-3520. [Google Scholar][Crossref]
  2. Andini D, Mulangsri K, dan Zulfa E. Uji Aktivitas Antibakteri Ekstrak Terpurifikasi Daun Mangga Arumanis (Mangifera indica L.) dan Identifikasi Flavonoid dengan KLT (Antibacterial Activity of Arumanis Mango Leaves (Mangifera indica L.) Purified Extract and Identification of Flavonoid. 2020; 6(1):55-62. [Google Scholar][Crossref]
  3. Arimaswati Sawaluddin M, Sudrajat WH. Efek Larvasida Ekstrak Biji Buah Pepaya (Carica papaya L.) terhadap Larva Instar III Aedes aegypty L. Fakultas Kedokteran Halu Oleo. 2017; 4(2):339. [Google Scholar][Crossref]
  4. Erwiyani AR, Gultom DSR, Oktianti D. Penetapan Kadar Flavonoid Total Ekstrak Etanol Biji Pinang (Areca catechu L.) Menggunakan Metode AlCl3. Indonesian Journal of Pharmacy and Natural Product, 2021, 4(1). [Google Scholar][Crossref]
  5. Fadilla Z, Hadi UK, Setiyaningsih S. Bioekologi vektor demam berdarah dengue (DBD) serta deteksi virus dengue pada Aedes aegypti (Linnaeus) dan Ae. albopictus (Skuse)(Diptera: Culicidae) di kelurahan endemik DBD Bantarjati, Kota Bogor. Jurnal Entomologi Indonesia. 2015; 12(1):31-31. [Google Scholar][Crossref]
  6. Fitri L, Yasmin Y. The Potential of Local Chitinolitic Bacteria Isolates as Larvacide of Aedes aegypti L. Makara Journal of Health Research, 2014, 1-6. [Google Scholar][Crossref]
  7. Gautam K, Kumar P, Poonia S. Larvicidal Activity and GC-MS Analysis of Flavonoids of Vitex Negundo and Andrographis paniculata against Two Vector Mosquitoes Anopheles Stephensi and Aedes aegypti. J Vector Borne Dis. 2013; 50(3):171-8. [Google Scholar][Crossref]
  8. Hasanah A, Hermansyah B, dan Abrori C. The Larvacidal Activity of Ethanol Extracts of Phyllanthus acidus Leaves on The Culex quinquefasciatus Instar III/IV Larvae. Journal of Agromedicine and Medical Sciences. 2019; 5(2):24. https://doi.org/10.19184/ams.v5i2.6842 [Google Scholar][Crossref]
  9. Irawan PA, dan K Krisyanella. Diversitas golongan darah sistem abo berdasarkan riwayat demam berdarah dengue pada mahasiswa di padang harapan kota bengkulu. Jurnal Media Kesehatan. 2020; 13(2):129-137. [Google Scholar][Crossref]
  10. Januarti IB, Wijayanti R, Wahyuningsih S dan Z Nisa. Potensi ekstrak terpurifikasi daun sirih merah (piper crocatum ruiz &pav) sebagai antioksidan dan antibakteri. JPSCR: Journal of Pharmaceutical Science and Clinical Research. 2019; 4(2):60-68. [Google Scholar][Crossref]
  11. Kewa MM, Almet J, Laut MM. Median Lethal Concentration (Lc50) Ekstrak Daun Sirsak (Annona muricata Linn) Terhadap Larva Culex sp Di Kota Kupang. Jurnal Kajian Veteriner. 2020; 8(2):147-152. [Google Scholar][Crossref]
  12. Khayyunida AN. Pengaruh Granula Ekstrak Etanol Daun Mindi (Melia azedarach L.) terhadap Mortalitas Larva Nyamuk Aedes aegypti L. Skripsi. Jember: Universitas Jember, 2014. [Google Scholar][Crossref]
  13. Kumara Candrama Jalu, et al. Efektivitas Flavonoid, Tanin, Saponin dan Alkaloid terhadap Mortalitas Larva Aedes aegypty. Proceeding of The URECOL, 2021, 106-118. [Google Scholar][Crossref]
  14. Kuncoro H, dan Rijai L. Uji Aktivitas Larvasida Ekstrak Daun Keladi Birah (Alocasia indica Schott) Terhadap Larva Nyamuk Culex sp., 2015. [Google Scholar][Crossref]
  15. Lensoni Surafi T, dan Isfanda. Efektivitas Ekstrak Bawang Putih (Alium sativum) Sebagai Biolarvasida Terhadap Larva Nyamuk Aedes aegypti. Jurnal Aceh Medika Universitas Abulyatama. 2019; 9623(1):71-76. [Google Scholar][Crossref]
  16. Manurung DP, Sundaryono A, H Amir. Penentuan potensi ekstrak kulit batang tumbuhan sikkam (bischofia javanica blume) sebagai antioksidan dengan metode dpph dan sitotoksik dengan metode bslt. Alotrop, 2020, 4(1). [Google Scholar][Crossref]
  17. Meidianti S Muanis, NA dan A Raharjo. Petunjuk Praktis Membuat Pestisida Organik. Edisi Pertama. Jakarta: Agromedia Pustaka, 2010. [Google Scholar][Crossref]
  18. Mulangsari DAK, E Zulfa. Uji aktivitas antibakteri ekstrak terpurifikasi daun mangga arumanis (mangifera indica l.) dan identifikasi flavonoid dengan KLT. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)(e-Journal). 2020; 6(1):55-62. [Google Scholar][Crossref]
  19. Nadila I, Istiana dan E. Whydiamata. Aktivitas Larvasida Ekstrak Etanol Daun Binjai (Mangifera caesia) terhadap Larva aedes aegypti. Jurnal Berkala Kedokteran. 2017; 1(13):61-68. [Google Scholar][Crossref]
  20. Novera R. Pemanfaatan Eksttrak Daun Jeruk Purut (Citrs hystrix), 2017, 78-89. [Google Scholar][Crossref]
  21. Prijono D. Prospek dan strategi pemanfaatan pestisida alami dan PHT. Bahan pelatihan pengembangan dan pemanfaatan pestisida alami. Bogor: Pusat Kajian Pengendalian, 1999. [Google Scholar][Crossref]
  22. Puspitasari AD, Pramono S. Perbandingan Metode Pembuatan Ekstrak Terpurifikasi Bee Propolis Dari Lebah Madu (Apis mellifera) Berdasarkan Kadar Flavonoid Total Dihitung Sevagai Rutin, Trad. Med. J. 2015; 20(2):76-81. [Google Scholar][Crossref]
  23. Puzi WS, Y Lukmayani, dan UA Dasuki. Isolasi dan Identifikasi Senyawa Flavonoid dari Daun Tumbuhan Sirih Merah (Piper crocatum Ruiz&Pav). Prosiding Penelitian SpeSIA.Unisba, 2015. [Google Scholar][Crossref]
  24. Rijayanti RP. Uji Aktivitas Antibakteri Ekstrak Etanol Daun Mangga Bacang (Mangifera foetidaL.) Terhadap Staphylococcus aureusSecara In Vitro. Skripsi. Fakultas Kedokteran Universitas Tanjungpura, Pontianak, 2014. [Google Scholar][Crossref]
  25. Siahaya V dan R Rumthe. Uji ekstrak daun papaya (Carica papaya) terhadap larva Plutella xylostella. Jurmal Ilmu Budidaya Tanaman. 2014; 3(2):112-116. [Google Scholar][Crossref]
  26. Sukmawati S, Ishak H, Arsin AA. Uji kerentanan untuk insektisida malathion dan cypermethrine (CYF 50 ec) terhadap populasi nyamuk Aedes aegypti di Kota Makassar dan Kabupaten Barru. HIGIENE: Jurnal Kesehatan Lingkungan. 2018; 4(1):1-47. [Google Scholar][Crossref]
  27. Susanti M, Kuncoro H, dan Rijai L. Uji Aktivitas Larvasida Ekstrak Daun Keladi Birah (Alocasia indica Schott) Terhadap Larva Nyamuk Culex sp. Jurnal Sains Dan Kesehatan. 2015; 1(1):5-10. [Google Scholar][Crossref]
  28. Supriningrum R, Sundu R, Setyawati D. Penetapan Kadar Flavonoid Ekstrak Daun singkil (Premna corymbosa) Berdasarkan Variasi Suhu dan Waktu International Journal of Medical and All Body Health Research www.allmedicaljournal.com Pengeringan Simplisia. Jurnal Farmasi Lampung, 2018, 7(1). [Google Scholar][Crossref]
  29. Tonius J, Wibowo MA, dan Idiawati N. Isolasi Dan Karakterisasi Senyawa Steroid Fraksi N -Heksana Daun Buas-Buas (Premna serratifolia L.). JKK. 2016; 5(1):1-7. [Google Scholar][Crossref]
  30. Triana M. Uji aktivitas antibakteri ekstrak etanol, fraksi n-heksana dan etil asetat daun mindi (Melia azedarach L.) Terhadap bakteri staphylococcus aureus dan escherichia coli. Skripsi. Medan: Universitas Sumatera Utara, 2016. [Google Scholar][Crossref]
  31. Taufiq Yuniarni, dan Hazar. Uji Aktivitas Bakteri Ekstrak Etanol Biji Buah Pepaya (Carica papaya L.) terhadap Eschericia coli dan Salmonella typhi. Prosiding Penelitian pesi Usiba, 2015. ISSN 22460-6472 [Google Scholar][Crossref]
  32. Wahyuni DIL. Perbedaan Toksisitas Daun Sirih (Piper betle L.) dengan Ekstrak Biji Srikaya (Annona squamosal L.) Terhadap Larva Nyamuk Aedes aegypti L. 2015; 17(2):38-34. [Google Scholar][Crossref]
  33. Wahyuni D, Dewi DP, Suratno. Toksisitas Granula Ekstrak Biji Alpukat (Persea americana Mill.) Terhadap Mortalitas Larva Nyamuk Aedes aegypti L. Artikel Ilmiah Hasil Penelitian Mahasiwa, 2014, 1-5. [Google Scholar][Crossref]
  34. Wahyuningsih NE, Sihit RA. Perbedaan respon Aedes aegypti (Linnaeus) (Diptera: Culicidae), terhadap paparan anti nyamuk bakar dan bunga keluwih (Artocarpus camansi, Blanco). Jurnal Entomologi Indonesia. 2015; 12(1):20-20. [Google Scholar][Crossref]
  35. Widyanto FC, dan C Triwibowo. Trend Desease Trend Penyakit Saat Ini. Jakarta: CV Trans Info Medika, 2013. [Google Scholar][Crossref]
  36. Yusuf MI, Tee SA, dan Jabbar A. Efek Hepatoprotektor Ekstrak Terpurifikasi Batang Galing (Cayratia trifolia L. Domin) Pada Tikus Putih Wistar Jantan (Rattus noervegicus), 2018, 4(1). [Google Scholar][Crossref]

How to Cite

Wahyuni, D., Waluyo, J., Putri, R. M., & Zahroh, U. A. (2023). Toxicity of Chinaberry Leaf Purified Extract (Melia azedarach L.) and Creekpremna Leaf (Premna serratifolia L.) to Aedes aegypti L Larval Mortality. International Journal of Medical and All Body Health Research, 4(3), 17-23.

Wahyuni, Dwi, et al. "Toxicity of Chinaberry Leaf Purified Extract (Melia azedarach L.) and Creekpremna Leaf (Premna serratifolia L.) to Aedes aegypti L Larval Mortality." International Journal of Medical and All Body Health Research, vol. 4, no. 3, 2023, pp. 17-23.

Wahyuni, D., Waluyo, J., Putri, R. M. and Zahroh, U. A. (2023) 'Toxicity of Chinaberry Leaf Purified Extract (Melia azedarach L.) and Creekpremna Leaf (Premna serratifolia L.) to Aedes aegypti L Larval Mortality', International Journal of Medical and All Body Health Research, 4(3), pp. 17-23.

Wahyuni D, Waluyo J, Putri RM, Zahroh UA. Toxicity of Chinaberry Leaf Purified Extract (Melia azedarach L.) and Creekpremna Leaf (Premna serratifolia L.) to Aedes aegypti L Larval Mortality. International Journal of Medical and All Body Health Research. 2023;4(3):17-23.

Similar Articles

Share

Find this Article on

Google Scholar Semantic Scholar OpenAlex ResearchGate BASE

A newly published article may take a few days to appear on these services.