International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

Current Issues
     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Phylogenetic analysis, pathogenesis, diagnosis and treatment: A review of Brucellosis and pig Brucella

Article Information

Volume / Issue4 / 2 (April-June 2023)
Pages29-35
AccessOpen Access

Publication Timeline

  • Received15 May 2023
  • Accepted02 June 2023

Full Text (PDF)

Open Access - Free to Download

Download Full Article (PDF) JATS XML

Abstract

Distinctive phenotypic characteristics are basic points to classify Brucella in to groups. The bacteria are also grouped into smooth and rough strains depending on the presence or absence of LPS on the O-side chain. They similarly classified according to their host preference though their host-pathogen association is not restricted. They lacks the actual pathogen-associated molecular patters (PAMPs) and classical virulence factors so they are hidden from early detection of immune system and protect themselves from bactericidal mechanisms. B.suis has wide host range with greatest phylogenetic distance between biovar having the most diverse strain of Brucella species. It is more generalized and chronic disease localized in the reproductive organs and the bones in pigs than bovine brucellosis. Nevertheless due to a decreased assumption and theory of reduced risk of human infection, emphasis was not given. The acquired immunity, antigen specific recognition of pathogens by the B lymphocytes has limited effect on protection of infection but is useful for diagnosis of disease. CELISA reduces reactions due to antibodies against vaccination and cross reactions subsequently during surveillance study of pig Brucellosis combinations of  methods ELISA of Yersinia (Ye O: 9) and Brucellosis are important. Treatment should prevent extra complication, relapse of disease and enable quick relief. Preventing is economical than to try to control diseases, it’s therefore important reviewing the different characteristics/ nature of Brucella.

 

References

  1. Alavi SM, L Alavi. Treatment of brucellosis: a systematic review of studies in recent twenty years. Caspian. J. Intern. Med. 2013; 4(2):636-41. [Google Scholar][Crossref]
  2. Albert D, López-Goñi I, García-Yoldi D, Marín C, Miguel M. New Bruce-ladder multiplex PCR assay for the biovar typing of Brucella suis and the discrimination of Brucella suis and Brucella canis. Vet Microbiology. 2011; 154:152-55. [Google Scholar][Crossref]
  3. Anazi KA, Jasser AM. Brucellosis: a global reemerging zoonosis; diagnosis, treatment and prevention:, 2014, http://www.esciencecentral.org/ebooks/bacterial mycotic infections/brucellosis-3.php. [Google Scholar][Crossref]
  4. Adem A, Duguma A. Characteristics and Intracellular Life of Brucella Organism: Journal of Microbiology & Biochemical. A Review. 2020; 12:431. [Google Scholar][Crossref]
  5. Banai M, Corbel M. Taxonomy of Brucella. The Open Veterinary Science Journal. 2010; 4:85-10. [Google Scholar][Crossref]
  6. Bari L, Hossain MA, Isshiki K, Ukuku DO. Behavior of Yersinia enterocolitica in Foods. Journal of Pathogens, 2011. [Google Scholar][Crossref]
  7. Bohlin J, Snipen L, Cloeckaert A, Lagesen K, Ussery D, Kristoffersen AB et al. Genomic comparisons of Brucellaspp. and closely related bacteria using base compositional and proteome based methods. BMC. Evol.Biol. 2010; 10:249. [Google Scholar][Crossref]
  8. Byndloss MX, Tsolis RM, Brucella SPP. Virulence factors and immunity. Annu Rev Anim Biosci. 2016; 4(1):11-27. [Google Scholar][Crossref]
  9. Campos PC, Gomes MTR, Guimaraes G, Costa Franco MM, Marim FM, Oliveira SC. Brucella abortus DNA is a major agonist to activate the host innate immune system. Microbes Infect. 2014; 16:979-84. [Google Scholar][Crossref]
  10. Cem Gul H, Hakan Erdem, Mandell, Douglas, Bennett’s. Principles and Practice of Infectious Diseases (Eighth Edition). Brucellosis (Brucella Species). 2015; V2.pp1. [Google Scholar][Crossref]
  11. CDC. Brucellosis reference guide: exposures, testing, and prevention. Atlanta, GA: US Department of Health and Human Services. Centers for Disease Control and Prevention, 2017, Available from: www.cdc.gov/brucellosis/pdf/brucellosi reference-guide.pdf. [Google Scholar][Crossref]
  12. Çiftci A, İça T, Savaşan S, Sareyyüpoğlu B, Akan M, Diker KS. Evaluation of PCR methods for detection of Brucellastrains from culture and tissues. Trop Anim Health Prod. 2017; 49(4):55-63. [Google Scholar][Crossref]
  13. Dahouk S, Sprague LD, Neubauer H. New developments in the diagnostic procedures for zoonotic brucellosis in humans. Revised science and technology Off International Epizoote. 2013; 32:177-88. [Google Scholar][Crossref]
  14. David R Bundle, John McGiven. Brucellosis: Improved Diagnostics and Vaccine Insights from Synthetic Glycans. Accounts of Chemical Research. 2017; 50(12):2958-67. [Google Scholar][Crossref]
  15. Diacovich L, Gorvel J. Bacterial manipulation of innate immunity to promote infection. Nat Rev Microbiol. 2010; 8:117-28. [Google Scholar][Crossref]
  16. Díaz R, Casanova A, Ariza J, Moriyón I. The Rose Bengal Test in human brucellosis: a neglected test for the diagnosis of a neglected disease. PLoSNegl Trop Dis. 2011; 5:e950. [Google Scholar][Crossref]
  17. Ducrotoy M Raquel, Conde-Álvarez, José María, Blasco Ignacio Moriyónb. A review of the basis of the immunological diagnosis of ruminant brucellosis. Veterinary Immunology and Immunopathology. 2016; 171.81-102. [Google Scholar][Crossref]
  18. El Sayed A, Walid Awad. Brucellosis: Evolution and expected comeback: International Journal of Veterinary Science and Medicine. 2018; 1(8):31-5. [Google Scholar][Crossref]
  19. Eoh H, Jeon Y, Kim Z, Kim C, Cho N. Expression and validation of Derythrulose 1-phosphate dehydrogenase from B. abortus: a diagnostic reagent for bovine brucellosis. J. Vet. Diagn. Invest. 2010; 22:524-30. [Google Scholar][Crossref]
  20. Fabien G, Bénédicte M, David H, Charles ichaux, Karl Walravens, Annick Linden. A serological and bacteriological survey of brucellosis in wild boar (Susscrofa) in Belgium.BMC Vet Res. 2012; 8:80. [Google Scholar][Crossref]
  21. Faramarz M, Shabnam R, Reza M, Khosrow Z. Immunogenic and protective antigens of Brucella as vaccine candidates. Comp ImmunolMicrobiol Infect Dis. 2019; 65:29-36. [Google Scholar][Crossref]
  22. Fredriksson-Ahomaa M, Meyer C, Bonke R, Stüber E, Wacheck S. Characterization of Yersinia enterocolitica 4/O:3 isolates from tonsils of Bavarian slaughter pigs. Letters in Applied Microbiology. 2010; 50(4):412-418. [Google Scholar][Crossref]
  23. Ficht T. Brucella taxonomy and evolution. Future microbiology. 2010; 5(6):859-66. [Google Scholar][Crossref]
  24. Figueiredo PThomas, A Ficht, AllisonRice-Ficht, Carlos A, Rossetti L Garry Adams. Pathogenesis and Immuno-biology of Brucellosis: Review of Brucella–Host Interactions. The American Journal of Pathology. 2015; 185 (6):1505-17. [Google Scholar][Crossref]
  25. Garibyan L, Avashia N. Polymerase chain reaction. J Invest Dermatol. 2013; 133(3):e6. [Google Scholar][Crossref]
  26. Glowacka P, Dorota Ż, Katarzyna N, Marcin N, Agata B Dróz. Brucella -Virulence Factors, Pathogenesis and Treatment. Polish journal of Microbiology. 2018; 67(2):151-61. [Google Scholar][Crossref]
  27. Godfroid J, Nielsen K, Saegerman C. Diagnosis of Brucellosis in Livestock and Wildlife. Croatian Medical Journal. 2010; 51(4):296-305. [Google Scholar][Crossref]
  28. Godfroid J, Scholz H, Barbier T, Nicolas C, Wattiau P, Fretin D, et al. Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century. Prev Vet Med. 2011; 102:118-31. [Google Scholar][Crossref]
  29. Guzmán-Verri C, Suárez-Esquivel M, Ruíz-Villalobos N, Zygmunt MS., Gonnet M, Campos E, et al. Genetic and Phenotypic Characterization of the Etiological International Journal of Medical and All Body Health Research www.allmedicaljournal.com Agent of Canine Orchiepididymitis Smooth Brucella sp. BCCN84.3. Frontiers in Veterinary Science. 2019; 6:175. [Google Scholar][Crossref]
  30. Haag AF, Myka KK, Arnold MF, Caro Hernández P, Ferguson GP. Importance of Lipopolysaccharide and Cyclic β 1, 2 Glucans in Brucella Mammalian Infections. International journal of microbiology. 2010; 124509. [Google Scholar][Crossref]
  31. Herrick JA, Lederman RJ, Sullivan B, Powers JH, Palmore TN. Brucella arteritis: clinical manifestations, treatment, and prognosis. Lancet Infect Dis. 2014; 14(6):520-26. [Google Scholar][Crossref]
  32. Higgins J, Stuber T, Quance C, et al. Molecular epidemiology of Brucella isolates from cattle, elk, and bison in the United States, 1998 to 2011. ApplEnviron Microbiol. 2012; 78(10):3674-84. [Google Scholar][Crossref]
  33. Kauffman LK, Bjork JK, Gallup JM, Boggiatto PM, Bellaire BH. Early detection of Brucella canis via quantitative polymerase chain reaction analysis. Zoonoses Public Health. 2014; 61(1):48-54. [Google Scholar][Crossref]
  34. Kim S. The interaction between Brucella and the host cell in phagocytosis, In: Baddour M. (ed.). Updates on Brucellosis. In Tech, Jinju, 2015, 45-60. [Google Scholar][Crossref]
  35. Le Flèche P, Jacques I, Grayon M, AL Dahouk S, Bouchon P, Denoeud F, et al. Evaluation and selection of tandem repeat loci for a Brucella MLVA typing assay.BMC Microbiology. 2006; 6:1-14. [Google Scholar][Crossref]
  36. Lim J, Kim H, Lee J, Kim G, Min W, Lee J, et al. Evaluation of recombinant 28 kDa outer membrane protein of B. abortus for the clinical diagnosis of bovine brucellosis in Korea. J. Vet. Med. Sci. 2012; 74(6):687-91. [Google Scholar][Crossref]
  37. Lopes LB, Nicolino R, Haddad JPA. Brucellosis-Risk Factors and Prevalence: A Review, The Open Veterinary Science Journal. 2010; 4:72-84. [Google Scholar][Crossref]
  38. Maiden MC, Van Rensburg MJJ, Bray JE, Earle SG, Ford SA, Jolley KA, et al. Mlst revisited: the gene-by-gene approach to bacterial genomics. Nat. Rev. Microbiol. (england). 2013; 11(10):728-36. [Google Scholar][Crossref]
  39. Marco Túlio R Gomes, Priscila C Campos, Leonardo A de Almeida, Fernanda S Oliveira, Miriam Maria S. Costa, Fernanda M Marim, et al. The role of innate immune signals in immunity to Brucellaabortus. Front Cell Infect Microbiol. 2012; 2:130. [Google Scholar][Crossref]
  40. Martirosyan A, Gorvel JP. Brucellaevasion of adaptive immunity. Future Microbiol. 2013; 8:147-54. [Google Scholar][Crossref]
  41. McGiven JA, Nicola A, Commander NJ, Duncombe L, Taylor AV, Villari S, et al. An evaluation of the capability of existing and novel sero-diagnostic methods for porcine brucellosis to reduce false positive serological reactions. Vet. Microbiol. 2012; 160:378-86. [Google Scholar][Crossref]
  42. Megid J, Mathias LA, Robles CA. Clinical Manifestations of Brucellosis in Domestic Animals and Humans. The Open Veterinary Science Journal. 2010; 4(1):119-26. [Google Scholar][Crossref]
  43. Mizak L, Gryko R, Parasion S, Kwiatek M. Brucellosis a worldwide zoonosis (in Polish). Życ. Wet. 2014; 89(1):35-40. [Google Scholar][Crossref]
  44. Moges W. Zoonosis Due to Bruella suis with Special Reference to Infection in Dogs (Carnivores): A Brief Review.Open Journal of Veterinary Medicine. 2013; 3(2):213-21. [Google Scholar][Crossref]
  45. Naik RV, Murthy H, Prakash HK, Peerapur BVA. Comparative study of Micro plate Agglutination Test (MAT) with Enzyme Linked Immunosorbant Assay (ELISA) for diagnosis of brucellosis. Int J Curr Microbiol App Sci. 2017; 6(10):1550-58. [Google Scholar][Crossref]
  46. OIE. Porcine brucellosis. Version adopted by the World Assembly of Delegates of the OIE. Terrestrial Manual, 2009, 1106-12 [Google Scholar][Crossref]
  47. OIE. Bovine brucellosis.Office International des Epizoo ties (OIE).Terrestrial Manual, 2012, pp. 616-50. [Google Scholar][Crossref]
  48. OIE. Brucellosis.(B. abortus, B.melitensis and B. suis). Adopted by the World Assembly of Delegates of the Of fice International des Epizooties (OIE).Terrestrial Manu al. Brucellosis Infection. 2016; 2:1-14. [Google Scholar][Crossref]
  49. OIE. Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. In B. abortus, B. melitensisand B. suis: Office International Des Epizooties World Organization for Animal Healt (OIE), Paris, France, 2017. [Google Scholar][Crossref]
  50. OIE. World Organisation for Animal Health. Brucellosis (B. abortus, B.melitensis and B.suis) (Infection with B. abortus, B. melitensis and B. suis). Manual of Diagnostic Tests and Vaccines for Terrestrial Animals, 2018. [Google Scholar][Crossref]
  51. Olsen SC, Tatum FM. Swine brucellosis: current perspectives. Vet Med(Auckland, N.Z.). 2016; 8(1):1-12. [Google Scholar][Crossref]
  52. Paul Nicoletti. Brucellosis in Pigs. College of Veterinary Medicine, University of Florida, 2019. [Google Scholar][Crossref]
  53. Perrett L, Mcgiven A, Brew D, Stack A. Evaluation of competitive ELISA for detection of antibodies to Brucella infection in domestic animals. Croat. Med. J. 2010; 51:314-19. [Google Scholar][Crossref]
  54. Poester PP, Nielsen K, Samartino LE, Yu WL. “Diagnosis of Brucellosis,” The Open Veterinary Science Journal. 2010; 4:46-60. [Google Scholar][Crossref]
  55. Ranjbar M. Treatment of brucellosis In Baddour M .Updates on Brucellosis in Tech, Teheran, 2015, pp. 171-84. [Google Scholar][Crossref]
  56. Sagar Aryal. Real Time PCR- Principle, Process, Markers, Advantages. Online Microbiology and Biology Notes, 2020. [Google Scholar][Crossref]
  57. Salcedo SP, Marchesini MI, Degos C, Terwagne M, Von Bargen K, Lepidi H, et al. A novel Brucella TIR containing effectors protein with immune modulatory functions. Front Cell Infect Microbial. 2013; 3:28. [Google Scholar][Crossref]
  58. Sankarasubramanian J, Vishnu US, Gunasekaran P, Rajendhran J. A genomewide SNP-based phylogenetic analysis distinguishes different biovars of Brucella suis. Infect.Genet. Evol. (Netherlands). 2016; 41:213-17. [Google Scholar][Crossref]
  59. Scholz HC, Vergnaud G. Molecular characterization of Brucella species. Rev SciTech. 2013; 32:149-62. [Google Scholar][Crossref]
  60. Scholz HC, Revilla Fernández S, Al Dahouk Jens AH, Ammerl Michel S, Zygmunt Axel Cloeckaert et al. Brucella vulpis sp. nov.,isolated from mandibular lymph nodes of red foxes. Int J Syst Evol Microbiol. National Library of Medicine. 2016; 66(5):2090-98. [Google Scholar][Crossref]
  61. Skendros P, Pappas G, Boura P. Cell mediated immunity in human brucellosis. Microbes Infect. 2011; 13:134-42 [Google Scholar][Crossref]
  62. Skendros P, Boura P. Immunity to brucellosis. Revue Scientifique Tech Int Off of Epizootics. 2013; 32:137-47. [Google Scholar][Crossref]
  63. et al. Current Methods of Human and Animal Brucellosis Diagnostics. Advances in Infectious Diseases. 2013; 3:177-84. International Journal of Medical and All Body Health Research www.allmedicaljournal.com [Google Scholar][Crossref]
  64. Solís JG, Del, Pozo J Solera. Treatment of human brucellosis-review of evidence from clinical trials, In: Baddour M. (eds). Updates on Brucellosis. InTech, Villarrobledo, Albacete, 2015, pp. 186-89. [Google Scholar][Crossref]
  65. Sriranganathan N, Mohamed NS, Stephen MB. Brucellosis: A reemerging zoonosis .Vet. Microbiol. 2010; 140:392-98. [Google Scholar][Crossref]
  66. Stoffregen WC, Johnson CS, Olsen SC. Immunogenicity and safety of a natural rough mutant of Brucellasuis as a vaccine for swine. Res Vet Sci. 2013; 95(2):451-58. [Google Scholar][Crossref]
  67. Tan KK, Tan YC, Chang LY, Lee KW, Nore SS, Yee WY, et al. Full genome SNP-based phylogenetic analysis reveals the origin and global spread of Brucella melitensis. BMC Genomics.(England). 2015; 16(1):2-11. [Google Scholar][Crossref]
  68. Vidal JL, Ortiz LF, Olivera M. An Overview on the Ph ylogenetic Classification of Brucella Evolution EN LA Classification Filogenética DE Brucella. Rev. U.D.C.A Act. &Div.Cient. 2018; 21(1):109-18. [Google Scholar][Crossref]
  69. Wang Y, Wang Z, Chen X, Zhang H, Guo F, Zhang K. et al. The Complete Genome of Brucella suis 019 Provides Insights on Cross-Species Infection. Genes. 2016; 7(2):7. [Google Scholar][Crossref]
  70. Wattam AR, Foster JT, Mane SP, Beckstromsternberg SM, Beckstrom-Sternberg JM, Dickerman AW et al. Comparative phylogenomics and evolution of the Brucellae reveal a path to virulence. J. Bacteriol. 2014; 196(5):920-30. [Google Scholar][Crossref]
  71. Wattiau P, Whatmore AM, Van Hessche M, Godfroid J, Fretin D. Nucleotide polymorphism based single tube te st for robust molecular identification of all currently des cribed Brucella species. Appl Environ Microbio. 2011; l77:6674-79. [Google Scholar][Crossref]
  72. Xavier N, Santos L, Tatiane A, Andreas B, Renee M. Pathogenesis of Brucellaspecies. Open Vet. Sci. J. 2014; 4:109-18. [Google Scholar][Crossref]
  73. Yangquan. Analyses of Brucella pathogenesis, host im munity, and vaccine targets using systems biology and bioinformatics. Front Cell Infect Microbiol. 2012; 2:2. [Google Scholar][Crossref]
  74. Zhang B, Izadjoo M, HorkayneSzakaly I, Morrison A, Wear DJ. Medulloblastoma and brucellosis molecular e vidence of Brucella spp in association with central nervous system cancer. J Cancer. 2011; 2:136-41. [Google Scholar][Crossref]

How to Cite

Demena, G. K. (2023). Phylogenetic analysis, pathogenesis, diagnosis and treatment: A review of Brucellosis and pig Brucella. International Journal of Medical and All Body Health Research, 4(2), 29-35.

Demena, Getachew Kinfe. "Phylogenetic analysis, pathogenesis, diagnosis and treatment: A review of Brucellosis and pig Brucella." International Journal of Medical and All Body Health Research, vol. 4, no. 2, 2023, pp. 29-35.

Demena, G. K. (2023) 'Phylogenetic analysis, pathogenesis, diagnosis and treatment: A review of Brucellosis and pig Brucella', International Journal of Medical and All Body Health Research, 4(2), pp. 29-35.

Demena GK. Phylogenetic analysis, pathogenesis, diagnosis and treatment: A review of Brucellosis and pig Brucella. International Journal of Medical and All Body Health Research. 2023;4(2):29-35.

Share

Find this Article on

Google Scholar Semantic Scholar OpenAlex ResearchGate BASE

A newly published article may take a few days to appear on these services.