International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

Current Issues
     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Biological phenomenon of epithelial-Mesenchymal transformation in medullary thyroid cancer: An interesting case phenomenon

Article Information

Volume / Issue3 / 1 (January-March 2022)
Pages01-03
AccessOpen Access

Publication Timeline

  • Received10 December 2021
  • Accepted02 January 2022

Full Text (PDF)

Open Access - Free to Download

Download Full Article (PDF) JATS XML

Abstract

Medullary thyroid carcinoma (MTC) is the differentiated thyroid cancer arising from the neoplastic clonal proliferation of parafollicular C-cells within thyroid parenchyma. It is widely believed to be neuroectodermal in origin. We highlight a rare case scenario, wherein the pathological biology of tumour changed to a mesodermal plasmacytoma in the course of followup. Here we discuss this uniquely rare biological phenomenon of MTC exhibiting epithelial- mesenchymal transformation (EMT) at follow-up, drastically changing the course of management.

References

  1. De Groot JW, Plukker JT, Wolffenbuttel BH, Wiggers T, Sluiter WJ, Links TP. Determinants of life expectancy in medullary thyroid cancer: Age does not matter. Clin Endocrinol (Oxf). 2006; 65:729-36. [Google Scholar][Crossref]
  2. Hazard JB. The C cells (Parafollicular Cells) of the thyroid gland and medullary thyroid carcinoma. A review. Am J Pathol. 1977; 88:213-50. [Google Scholar][Crossref]
  3. Nilsson M, Williams D. On the Origin of Cells and Derivation of Thyroid Cancer: C Cell Story Revisited. Eur Thyroid J. 2016; 5:79-93. [Google Scholar][Crossref]
  4. Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest. 2003; 112:1776-1784. [Google Scholar][Crossref]
  5. Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest. 2009; 119:1429-1437. [Google Scholar][Crossref]
  6. Strutz F, et al. Identification and characterization of a fibroblast marker: FSP1. J Cell Biol. 1995; 130:393-405. [Google Scholar][Crossref]
  7. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002; 2:442-454. [Google Scholar][Crossref]
  8. Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell. 2008; 14:818-829. [Google Scholar][Crossref]

How to Cite

P, R. B., & M, S. (2022). Biological phenomenon of epithelial-Mesenchymal transformation in medullary thyroid cancer: An interesting case phenomenon. International Journal of Medical and All Body Health Research, 3(1), 01-03.

P, Ramakanth Bhargav, and Sabaretnam M. "Biological phenomenon of epithelial-Mesenchymal transformation in medullary thyroid cancer: An interesting case phenomenon." International Journal of Medical and All Body Health Research, vol. 3, no. 1, 2022, pp. 01-03.

P, R. B. and M, S. (2022) 'Biological phenomenon of epithelial-Mesenchymal transformation in medullary thyroid cancer: An interesting case phenomenon', International Journal of Medical and All Body Health Research, 3(1), pp. 01-03.

P RB, M S. Biological phenomenon of epithelial-Mesenchymal transformation in medullary thyroid cancer: An interesting case phenomenon. International Journal of Medical and All Body Health Research. 2022;3(1):01-03.

Share

Find this Article on

Google Scholar Semantic Scholar OpenAlex ResearchGate BASE

A newly published article may take a few days to appear on these services.