IJMABHR International Journal of Medical and All Body Health ResearchIJMABHR 2582-8940 Anfo Publication House 98 Biological phenomenon of epithelial-Mesenchymal transformation in medullary thyroid cancer: An interesting case phenomenon PRamakanth Bhargav MSabaretnam Senior Consultant Endocrine Surgeon, Endocare Hospital, Vijayawada, Andhra Pradesh, India Associate Professor, Department of Endocrine Surgery, SGPGIMS, Lucknow, Uttar Pradesh, India 2022 3 1 01 03 10122021 02012022 CC BY-NC-SA 4.0

Medullary thyroid carcinoma (MTC) is the differentiated thyroid cancer arising from the neoplastic clonal proliferation of parafollicular C-cells within thyroid parenchyma. It is widely believed to be neuroectodermal in origin. We highlight a rare case scenario, wherein the pathological biology of tumour changed to a mesodermal plasmacytoma in the course of followup. Here we discuss this uniquely rare biological phenomenon of MTC exhibiting epithelial- mesenchymal transformation (EMT) at follow-up, drastically changing the course of management.

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