International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

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     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Correlation between Pro-inflammatory biomarkers and papillary thyroid cancer: A case control Study

Bhargav PRK, Sabaretnam M

BGH, Andhra Ratna Road, Gandhi Nagar, Vijayawada, Andhra Pradesh, India

Article Information

Volume / Issue3 / 3 (July-September 2022)
Pages24-26
AccessOpen Access

Publication Timeline

  • Received03 August 2022
  • Accepted07 September 2022

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Abstract

Introduction: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. Apart from genetics, autoimmunity has been implicated in its pathogenesis. In this context, we set out to study the role of Pro- inflammatory cytokines in PTC in South Indian population.rnMaterial and methods: This pilot prospective case-control study was conducted on surgically managed PTC patients. Institutional ethical committee approval was obtained. Diagnosis of PTC was based on imaging, fine needle aspiration cytology and later confirmed by histopathology. Exclusion criteria were subjects with any disease or medication interfering with the hypothalamic-pituitary-gonadal axis. Serum samples were collected from 46 PTC subjects and 44 age matched healthy controls. Interleukin-6 (IL-6), Tumour necrosis factor-alpha (TNF-α) and high sensitive C reactive protein (hsCRP), leptin levels were measured in all serum samples. Statistical analysis was performed by one way ANOVA with Dunnet’s test and Pearson correlation tests.rnResults: The mean hSCRP level in PTC and controls were 18.3 ± 3.1 mg/mL and 5.5 ± 1.2 mg/mL respectively. The mean TNF-α level, IL-6 level and Leptin levels were 295 ± 28 pg/mL, 13.6 ± 4.4 pg/mL and 1.93 ± 0.8 ng/mL respectively. Serum leptin level in controls was 3.6 ±1.8 ng/mL. There was statistically significant difference of all the pro-inflammatory cytokines compared to controls (P value <0.05) with negative correlation for leptin levels. rnConclusions: Our study shows raised titers of pro-inflammatory markers – IL-6, TNF-α and hsCRP, while reduced leptin levels correlated with PTC suggesting a contributory role. But, the exact immuno-modulatory mechanism needs more research.

Keywords

Papillary thyroid cancerTumour necrosis factorInterleukin-6GoiterAuto-immunityLeptin

References

  1. Schlicke CP. Recent trends in thyroid surgery. Am J Surg. 1974; 128:269-275. [Google Scholar][Crossref]
  2. Clark OH, Greenspan FS, Dunphy JE. Hashimoto’s thyroiditis and thyroid cancer: Indications for operation. Am J Surg. 1980; 140:65-71. [Google Scholar][Crossref]
  3. Pisanu A, Piu S, Cois A, Uccheddu A. Coexisting Hashimoto’s thyroiditis with differentiated thyroid cancer and benign thyroid diseases: indications for thyroidectomy. Chir Ital. 2003; 55(3):365-372. [Google Scholar][Crossref]
  4. Carli AF, Lottini M, Testa M, Neri A. Surgical treatment of Hashimoto’s thyroiditis. Personal experience. Minerva Chir. 2002; 57(2):117-122. [Google Scholar][Crossref]
  5. Kurukahvecioglu O, Taneri F, Yuksel O, Aydin A, Tezel E, Onuk E. Total thyroidectomy for the treatment of Hashimoto’s thyroiditis coexisting with papillary thyroid carcinoma. Adv Ther. 2007; 24(3):510-516. [Google Scholar][Crossref]
  6. Lai X, Xia Y, Zhang B, Li J, Jiang Y. A meta-analysis of Hashimoto's thyroiditis and papillary thyroid carcinoma risk. Oncotarget. 2017; 8(37):62414-62424. [Google Scholar][Crossref]
  7. Graceffa G, Patrone R, Vieni S, et al. Association between Hashimoto's thyroiditis and papillary thyroid carcinoma: a retrospective analysis of 305 patients. BMC Endocr Disord. 2019; 19(Suppl 1):26. International Journal of Medical and All Body Health Research www.allmedicaljournal.com [Google Scholar][Crossref]
  8. Hussein O, Abdelwahab K, Hamdy O, et al. Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area. J Egypt Natl Canc Inst. 2020; 32:7. [Google Scholar][Crossref]
  9. Beksac K, Sonmez C, Cetin B, Kismali G, Sel T, Tuncer Y, et al. Evaluation of pro inflammatory cytokine and neopterin levels in women with papillary thyroid carcinoma. Int J Biol Markers. 2016; 31(4):e446-e450. [Google Scholar][Crossref]
  10. Wang W, Chang J, Jia B, Liu J. The Blood Biomarkers of Thyroid Cancer. Cancer Manag Res. 2020; 12:5431-5438. [Google Scholar][Crossref]
  11. Lin P, Yao Z, Sun Y, Li W, Liu Y, Liang K, et al. Deciphering novel biomarkers of lymph node metastasis of thyroid papillary micro carcinoma using proteomic analysis of ultrasound-guided fine-needle aspiration biopsy samples. J Proteomics. 2019; 204:103414. [Google Scholar][Crossref]
  12. Mahmoudian-Sani MR, Mehri-Ghahfarrokhi A, Asadi-Samani M, Mobini GR. Serum miRNAs as Biomarkers for the Diagnosis and Prognosis of Thyroid Cancer: A Comprehensive Review of the Literature. Eur Thyroid J. 2017; 6(4):171-177. [Google Scholar][Crossref]
  13. Wang H, Wang P, Wu Y, Hou X, Peng Z, Yang W, et al. Correlation between obesity and clinicopathological characteristics in patients with papillary thyroid cancer: a study of 1579 cases: A retrospective study. Peer J. 2020; 8:e9675. [Google Scholar][Crossref]

How to Cite

PRK, B., & M, S. (2022). Correlation between Pro-inflammatory biomarkers and papillary thyroid cancer: A case control Study. International Journal of Medical and All Body Health Research, 3(3), 24-26. https://doi.org/10.54660/Ijmabhr.2022.3.3.3

PRK, Bhargav, and Sabaretnam M. "Correlation between Pro-inflammatory biomarkers and papillary thyroid cancer: A case control Study." International Journal of Medical and All Body Health Research, vol. 3, no. 3, 2022, pp. 24-26. https://doi.org/10.54660/Ijmabhr.2022.3.3.3.

PRK, B. and M, S. (2022) 'Correlation between Pro-inflammatory biomarkers and papillary thyroid cancer: A case control Study', International Journal of Medical and All Body Health Research, 3(3), pp. 24-26. doi: 10.54660/Ijmabhr.2022.3.3.3.

PRK B, M S. Correlation between Pro-inflammatory biomarkers and papillary thyroid cancer: A case control Study. International Journal of Medical and All Body Health Research. 2022;3(3):24-26. doi:10.54660/Ijmabhr.2022.3.3.3

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