Efficacy and Safety of Oral Tofacitinib in Lichen Planus and Its Variants: A Prospective Interventional Study from a Tertiary Care Centre in Western Uttar Pradesh
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Abstract
Background: Lichen planus (LP) is a chronic, T-cell-mediated inflammatory dermatosis in which the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is increasingly implicated. Conventional therapies frequently yield incomplete or non-durable responses, creating a need for targeted options in progressive and refractory disease.
Objective: To evaluate the efficacy and safety of oral tofacitinib in patients with LP and its clinical variants.
Methods: A prospective interventional study enrolled 50 patients (aged 18–60 years) with clinically or histopathologically confirmed LP. Patients received oral tofacitinib 5 mg twice daily, escalated to 5 mg thrice daily for inadequate response, and were followed at 15-day intervals. Outcomes were assessed using the Physician Global Assessment (PGA), Visual Analog Scale (VAS) for pruritus, standardized photographic grading, and serial laboratory monitoring.
Results: Complete cutaneous response rose from 40% at 8 weeks to 72% at 18 weeks. Mean PGA fell from 3.5 to 0.8 and mean VAS from 7.6 to 1.2 (both p < 0.001). Classical and hypertrophic variants showed the highest excellent-response rates; the variant–response association was significant (p < 0.05). No serious adverse events occurred; a statistically significant but clinically manageable rise in total cholesterol was the only significant laboratory change (p = 0.01).
Conclusion: Oral tofacitinib was an effective and well-tolerated treatment for LP and its variants, supporting JAK–STAT inhibition as a rational therapeutic strategy in progressive or treatment-resistant disease.
How to Cite
Widhwani, D., Saxena, D., Kashyap, S., Noor, J., & Kainam (2026). Efficacy and Safety of Oral Tofacitinib in Lichen Planus and Its Variants: A Prospective Interventional Study from a Tertiary Care Centre in Western Uttar Pradesh. International Journal of Medical and All Body Health Research, 7(2), 269-273. https://doi.org/10.54660/IJMBHR.2026.7.2.269-273
Widhwani, Disha, et al. "Efficacy and Safety of Oral Tofacitinib in Lichen Planus and Its Variants: A Prospective Interventional Study from a Tertiary Care Centre in Western Uttar Pradesh." International Journal of Medical and All Body Health Research, vol. 7, no. 2, 2026, pp. 269-273. https://doi.org/10.54660/IJMBHR.2026.7.2.269-273.
Widhwani, D., Saxena, D., Kashyap, S., Noor, J. and Kainam (2026) 'Efficacy and Safety of Oral Tofacitinib in Lichen Planus and Its Variants: A Prospective Interventional Study from a Tertiary Care Centre in Western Uttar Pradesh', International Journal of Medical and All Body Health Research, 7(2), pp. 269-273. doi: 10.54660/IJMBHR.2026.7.2.269-273.
Widhwani D, Saxena D, Kashyap S, Noor J, Kainam. Efficacy and Safety of Oral Tofacitinib in Lichen Planus and Its Variants: A Prospective Interventional Study from a Tertiary Care Centre in Western Uttar Pradesh. International Journal of Medical and All Body Health Research. 2026;7(2):269-273. doi:10.54660/IJMBHR.2026.7.2.269-273
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