International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

Current Issues
     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Global Patterns of Polysubstance Abuse and Overdose Mortality During the COVID-19 Pandemic

Article Information

Volume / Issue3 / 3 (July-September 2022)
Pages55-58
AccessOpen Access

Publication Timeline

  • Received15 August 2022
  • Accepted21 September 2022

Full Text (PDF)

Open Access - Free to Download

Download Full Article (PDF) JATS XML

Abstract

COVID-19 emerged at a time when many countries were already struggling with an escalating opioid crisis and increasingly complex patterns of polysubstance abuse. Although global attention focused on the spread of the virus, individuals with substance use disorders faced major disruptions in care, unstable drug supplies, and heightened socioeconomic pressures. This narrative review synthesizes peer-reviewed literature published through 2021 to examine how the pandemic affected overdose mortality, patterns of polysubstance use, and access to services across diverse settings. Evidence from epidemiological studies, clinical research, and qualitative reports shows that fatal overdoses increased during the pandemic, driven by treatment disruptions, isolation, changes in drug availability, and emotional distress. Polysubstance involvement, including combinations of opioids, stimulants, and sedatives, played a significant role. While telehealth expansion and more flexible medication policies helped sustain treatment for some, these adaptations were unevenly implemented and did not fully reach structurally disadvantaged groups. The findings underscore the necessity for robust public health strategies that guarantee continuity of treatment, safeguard harm reduction programs, and mitigate socioeconomic inequities during future emergencies.

References

  1. An Epidemic in the Midst of a Pandemic. Opioid use disorder and COVID-19. Ann Intern Med. 2020;172(11):757-8. doi:10.7326/M20-1141 [Google Scholar][Crossref]
  2. A Tale of Two Epidemics. When COVID-19 and opioid addiction collide. Harvard Health Publishing. 2020 Apr 20. Available from: https://www.health.harvard.edu/blog/a-tale-of-two-epidemics-when-covid-19-and-opioid-addiction-collide-2020042019569 [Google Scholar][Crossref]
  3. Abramson A. Substance use during the pandemic. Monitor on Psychology. 2021;52(2):22. Available from: https://www.apa.org/monitor/2021/03/substance-use-pandemic [Google Scholar][Crossref]
  4. Chacon N, Walia N, Allen A, Sciancalepore A, Tiong J, Mada S, et al. Substance use during the COVID-19 pandemic: a rapid survey. Discoveries (Craiova). 2021;9(4):e141. doi:10.15190/d.2021.13 [Google Scholar][Crossref]
  5. Compton WM, Valentino RJ, DuPont RL. Polysubstance use in the U.S. opioid crisis. Mol Psychiatry. 2021;26(1):41-50. doi:10.1038/s41380-020-00959-9 [Google Scholar][Crossref]
  6. Dodge KA, Skinner AT, Godwin J, Bai Y, Lansford JE, Copeland WE, et al. Impact of the COVID-19 pandemic on substance use among adults without children, parents, and adolescents. Addict Behav Rep. 2021;14:100388. doi:10.1016/j.abrep.2021.100388 [Google Scholar][Crossref]
  7. Haley DF, Saitz R. The opioid epidemic during the COVID-19 pandemic. JAMA. 2020;324(16):1615-7. doi:10.1001/jama.2020.18543 [Google Scholar][Crossref]
  8. Joudrey PJ, Adams ZM, Bach P, Van Buren S, Chaiton JA, Ehrenfeld L, et al. Methadone access for opioid use International Journal of Medical and All Body Health Research www.allmedicaljournal.com disorder during the COVID-19 pandemic within the United States and Canada. JAMA Netw Open. 2021;4(7):e2118223. doi:10.1001/jamanetworkopen.2021.18223 [Google Scholar][Crossref]
  9. Khatri UG, Perrone J. Opioid use disorder and COVID-19: crashing of the crises. J Addict Med. 2020;14(4):e6-7. doi:10.1097/ADM.0000000000000684 [Google Scholar][Crossref]
  10. Linas BP, Savinkina A, Barbosa C, Mueller PP, Cerdá M, Keyes K, et al. A clash of epidemics: impact of the COVID-19 pandemic response on opioid overdose. J Subst Abuse Treat. 2021;120:108158. doi:10.1016/j.jsat.2020.108158 [Google Scholar][Crossref]
  11. Manchikanti L, Vanaparthy R, Atluri S, Sachdeva H, Kaye AD, Hirsch JA. COVID-19 and the opioid epidemic: two public health emergencies that intersect with chronic pain. Pain Ther. 2021;10(1):269-86. doi:10.1007/s40122-021-00254-3 [Google Scholar][Crossref]
  12. Niles JK, Gudin J, Radcliff J, Kaufman HW. The opioid epidemic within the COVID-19 pandemic: drug testing in 2020. Popul Health Manag. 2021;24(S1):S43-51. doi:10.1089/pop.2020.0230 [Google Scholar][Crossref]
  13. Ochalek TA, Cumpston KL, Wills BK, Gal TS, Moeller FG. Nonfatal opioid overdoses in the era of COVID-19: a retrospective chart review. JAMA. 2020 (cited in Haley & Saitz, reference 7). [Google Scholar][Crossref]
  14. Rosic T, Naji L, Sanger N, Marsh DC, Worster A, Thabane L, et al. Factors associated with increased opioid use during the COVID-19 pandemic: a prospective study in the province of Ontario. J Addict Med. 2022;16(4):e257 -64. doi:10.1097/ADM.0000000000000943 [Google Scholar][Crossref]
  15. Russell C, Ali F, Nafeh F, Rehm J, LeBlanc S, Elton-Marshall T. Identifying the impacts of the COVID-19 pandemic on service access for people who use drugs (PWUD): a national qualitative study. J Subst Abuse Treat. 2021 ;129:108374. doi:10.1016/j.jsat.2021.108374 [Google Scholar][Crossref]
  16. Silva MJ, Kelly Z. The escalation of the opioid epidemic due to COVID-19 and resulting lessons. Am J Manag Care. 2020;26(7):e202-4. doi:10.7326/M20-4213 [Google Scholar][Crossref]
  17. The COVID-19 Crisis Has Brought Substance Abuse to Light. Society for Human Resource Management. 2021. Available from: https://www.shrm.org/topics-tools/news/all-things-work/covid-19-crisis-brought-substance-abuse-to-light [Google Scholar][Crossref]
  18. Wang QQ, Kaelber DC, Xu R, Volkow ND. COVID-19 risk and outcomes in patients with substance use disorders: analyses from electronic health records in the United States. Mol Psychiatry. 2021;26(1):30-9. doi:10.1038/s41380-020-00880-7 [Google Scholar][Crossref]

How to Cite

Isa, A. K. (2022). Global Patterns of Polysubstance Abuse and Overdose Mortality During the COVID-19 Pandemic. International Journal of Medical and All Body Health Research, 3(3), 55-58. https://doi.org/10.54660/IJMBHR.2022.3.3.55-58

Isa, Aisha Katsina. "Global Patterns of Polysubstance Abuse and Overdose Mortality During the COVID-19 Pandemic." International Journal of Medical and All Body Health Research, vol. 3, no. 3, 2022, pp. 55-58. https://doi.org/10.54660/IJMBHR.2022.3.3.55-58.

Isa, A. K. (2022) 'Global Patterns of Polysubstance Abuse and Overdose Mortality During the COVID-19 Pandemic', International Journal of Medical and All Body Health Research, 3(3), pp. 55-58. doi: 10.54660/IJMBHR.2022.3.3.55-58.

Isa AK. Global Patterns of Polysubstance Abuse and Overdose Mortality During the COVID-19 Pandemic. International Journal of Medical and All Body Health Research. 2022;3(3):55-58. doi:10.54660/IJMBHR.2022.3.3.55-58

Share

Find this Article on

Google Scholar Semantic Scholar OpenAlex Scilit Crossref ResearchGate BASE

A newly published article may take a few days to appear on these services.