International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

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     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Evaluation of Peripapillary Retinal Nerve Fiber Layer Thickness and Macular Layer Thickness in Patients with or without Primary Open-Angle Glaucoma with Spectral Domain Optical Coherence Tomography

Dr. Priya Singh, Dr. Nupur Suman, Dr. Pushpalata Chaturvedi, Dr. Ruchi Saxena, Dr. Jyostna, Dr. Swati Bansal

Department of Ophthalmology, Saraswathi Institute of Medical Science, Hapur, Uttar Pradesh, India; Head of Department, Department of Ophthalmology, Saraswathi Institute of Medical Science, Hapur, Uttar Pradesh, India; Associate Professor, Department of Ophthalmology, Saraswathi Institute of Medical Science, Hapur, Uttar Pradesh, India; Assistant Professor, Department of Ophthalmology, Saraswathi Institute of Medical Science, Hapur, Uttar Pradesh, India

Article Information

Volume / Issue6 / 3 (July-September 2025)
Pages222-227
AccessOpen Access

Publication Timeline

  • Received06 July 2025
  • Accepted06 August 2025
  • Published

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Abstract

Primary open-angle glaucoma (POAG) is a progressive optic neuropathy characterized by retinal ganglion cell death and optic nerve head changes, leading to irreversible vision loss if left untreated. This study aimed to evaluate and compare peripapillary retinal nerve fiber layer (RNFL) thickness and macular layer thickness measurements using spectral domain optical coherence tomography (SD-OCT) in patients with POAG versus healthy controls. A total of 120 participants were enrolled, including 60 patients with confirmed POAG and 60 age-matched healthy controls. All participants underwent comprehensive ophthalmic examination including visual field testing, intraocular pressure measurement, and SD-OCT imaging using Heidelberg Spectralis OCT. Peripapillary RNFL thickness was measured in four quadrants (superior, inferior, nasal, and temporal), while macular thickness measurements included ganglion cell layer (GCL), inner plexiform layer (IPL), and total macular thickness. Results demonstrated significantly reduced peripapillary RNFL thickness in all quadrants in the POAG group compared to controls (p<0.001). Mean peripapillary RNFL thickness was 78.4±12.6 μm in POAG patients versus 96.7±8.9 μm in controls. Macular GCL-IPL thickness was significantly thinner in POAG patients (67.8±9.4 μm) compared to controls (82.3±6.7 μm, p<0.001). The inferior and superior quadrants showed the most pronounced RNFL thinning, consistent with the typical glaucomatous pattern of damage. Strong correlations were observed between RNFL thickness measurements and visual field parameters, with correlation coefficients ranging from 0.72 to 0.84. SD-OCT demonstrated excellent diagnostic capability with area under the receiver operating characteristic curve values of 0.92 for average RNFL thickness and 0.89 for macular GCL-IPL thickness. These findings confirm that SD-OCT is a valuable tool for early detection and monitoring of structural changes in glaucoma, providing objective quantitative measurements that correlate well with functional visual field defects and can aid in clinical decision-making for glaucoma management.

Keywords

Primary Open-Angle GlaucomaSpectral Domain Optical Coherence TomographyRetinal Nerve Fiber LayerMacular ThicknessGanglion Cell LayerDiagnostic ImagingOptic Neuropathy

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How to Cite

Singh, P., Suman, N., Chaturvedi, P., Saxena, R., Jyostna, & Bansal, S. (2025). Evaluation of Peripapillary Retinal Nerve Fiber Layer Thickness and Macular Layer Thickness in Patients with or without Primary Open-Angle Glaucoma with Spectral Domain Optical Coherence Tomography. International Journal of Medical and All Body Health Research, 6(3), 222-227. https://doi.org/10.54660/IJMBHR.2025.6.3.222-227

Singh, Priya, et al. "Evaluation of Peripapillary Retinal Nerve Fiber Layer Thickness and Macular Layer Thickness in Patients with or without Primary Open-Angle Glaucoma with Spectral Domain Optical Coherence Tomography." International Journal of Medical and All Body Health Research, vol. 6, no. 3, 2025, pp. 222-227. https://doi.org/10.54660/IJMBHR.2025.6.3.222-227.

Singh, P., Suman, N., Chaturvedi, P., Saxena, R., Jyostna and Bansal, S. (2025) 'Evaluation of Peripapillary Retinal Nerve Fiber Layer Thickness and Macular Layer Thickness in Patients with or without Primary Open-Angle Glaucoma with Spectral Domain Optical Coherence Tomography', International Journal of Medical and All Body Health Research, 6(3), pp. 222-227. doi: 10.54660/IJMBHR.2025.6.3.222-227.

Singh P, Suman N, Chaturvedi P, Saxena R, Jyostna, Bansal S. Evaluation of Peripapillary Retinal Nerve Fiber Layer Thickness and Macular Layer Thickness in Patients with or without Primary Open-Angle Glaucoma with Spectral Domain Optical Coherence Tomography. International Journal of Medical and All Body Health Research. 2025;6(3):222-227. doi:10.54660/IJMBHR.2025.6.3.222-227

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