IJMABHR International Journal of Medical and All Body Health ResearchIJMABHR 2582-8940 Anfo Publication House 387 10.54660/IJMBHR.2025.6.3.222-227 Evaluation of Peripapillary Retinal Nerve Fiber Layer Thickness and Macular Layer Thickness in Patients with or without Primary Open-Angle Glaucoma with Spectral Domain Optical Coherence Tomography SinghPriya SumanNupur ChaturvediPushpalata SaxenaRuchi Jyostna BansalSwati Department of Ophthalmology, Saraswathi Institute of Medical Science, Hapur, Uttar Pradesh, India Head of Department, Department of Ophthalmology, Saraswathi Institute of Medical Science, Hapur, Uttar Pradesh, India Associate Professor, Department of Ophthalmology, Saraswathi Institute of Medical Science, Hapur, Uttar Pradesh, India Assistant Professor, Department of Ophthalmology, Saraswathi Institute of Medical Science, Hapur, Uttar Pradesh, India 21082025 6 3 222 227 06072025 06082025 CC BY-NC-SA 4.0

Primary open-angle glaucoma (POAG) is a progressive optic neuropathy characterized by retinal ganglion cell death and optic nerve head changes, leading to irreversible vision loss if left untreated. This study aimed to evaluate and compare peripapillary retinal nerve fiber layer (RNFL) thickness and macular layer thickness measurements using spectral domain optical coherence tomography (SD-OCT) in patients with POAG versus healthy controls. A total of 120 participants were enrolled, including 60 patients with confirmed POAG and 60 age-matched healthy controls. All participants underwent comprehensive ophthalmic examination including visual field testing, intraocular pressure measurement, and SD-OCT imaging using Heidelberg Spectralis OCT. Peripapillary RNFL thickness was measured in four quadrants (superior, inferior, nasal, and temporal), while macular thickness measurements included ganglion cell layer (GCL), inner plexiform layer (IPL), and total macular thickness. Results demonstrated significantly reduced peripapillary RNFL thickness in all quadrants in the POAG group compared to controls (p

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