Abstract

The study carried out on 57 women with stillbirth in the second and third trimesters of pregnancy and was treatment by misoprostol at obstetrics and gynecology department in Vung Tay Nguyen General Hospital from 1/2024-12/2024. The success rate with medical abortion is 84,2%, of which the complete expulsion rate is 12,5%, incomplete is 87,5 %. The average total dose is 362,3 ± 290,3 mcg, which of 577,4 ± 227,6 mcg in second trimester and in third trimester is 105,8 ± 26,8 mcg (p<0,05). The average time to expulsion is 17,5 ± 7,9 hours, 81,3% case of study had vaginal birth achieved within 24 hours. In the cases had abdominal pain or vaginal bleeding, the average time to expulsion is shorter (p<0,05). There is no relationship between the number of previous pregnancies with expulsion results by misoprostol. Misoprostol is a safe and effective option for the management of intrauterine fetal demise in the second and third trimesters. But we need to consider dosage in the last third trimester to increase the treatment efficacy.