International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

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     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

The Treatment Results Stillbirth in the Second and Third Trimesters by Misoprostol

Article Information

Volume / Issue6 / 3 (July-September 2025)
Pages13-16
AccessOpen Access

Publication Timeline

  • Received08 May 2025
  • Accepted07 June 2025
  • Published

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Abstract

The study carried out on 57 women with stillbirth in the second and third trimesters of pregnancy and was treatment by misoprostol at obstetrics and gynecology department in Vung Tay Nguyen General Hospital from 1/2024-12/2024. The success rate with medical abortion is 84,2%, of which the complete expulsion rate is 12,5%, incomplete is 87,5 %. The average total dose is 362,3 ± 290,3 mcg, which of 577,4 ± 227,6 mcg in second trimester and in third trimester is 105,8 ± 26,8 mcg (p<0,05). The average time to expulsion is 17,5 ± 7,9 hours, 81,3% case of study had vaginal birth achieved within 24 hours. In the cases had abdominal pain or vaginal bleeding, the average time to expulsion is shorter (p<0,05). There is no relationship between the number of previous pregnancies with expulsion results by misoprostol. Misoprostol is a safe and effective option for the management of intrauterine fetal demise in the second and third trimesters. But we need to consider dosage in the last third trimester to increase the treatment efficacy.

References

  1. Gomez R, Wing D. Misoprostol for termination of pregnancy with intrauterine fetal demise in the second and third trimester of pregnancy - a systematic review. Contraception. 2009;79(4):259 -71. doi:10.1016/j.contraception.2008.10.012. [Google Scholar][Crossref]
  2. Sultana Z, Rahman MM, Begum M, Akhter S, Nahar K. Induction by misoprostol in case of intrauterine fetal death: a cross-sectional study. Mymensingh Med J. 2020;29(3):616-22. [Google Scholar][Crossref]
  3. Amin KV, Chauhan AR, Goel A. Current practices of cervical ripening and induction of labour in intrauterine foetal demise: an observational study. J Obstet Gynaecol India. 2019;69(1):37-42. doi:10.1007/s13224-018-1113-9. [Google Scholar][Crossref]
  4. Das SR, Akhter S, Begum M, Nahar K. Safety and efficacy of different doses of misoprostol in termination International Journal of Medical and All Body Health Research www.allmedicaljournal.com of intrauterine fetal death (IUFD) cases. Bangladesh J Obstet Gynaecol. 2016;28(1):15-20. [Google Scholar][Crossref]
  5. Gomez R, Wing D, Fiala C. Misoprostol for intrauterine fetal death. Int J Gynaecol Obstet. 2007;99 Suppl 2:S190-3. doi:10.1016/j.ijgo.2007.09.004. [Google Scholar][Crossref]
  6. Palod S, Nayak T. Use of misoprostol for termination of second and third trimester pregnancy with intrauterine foetal death. Int J Reprod Contracept Obstet Gynecol. 2016;5(4):1216-21. doi:10.18203/2320 -1770.ijrcog20160931. [Google Scholar][Crossref]
  7. Cetin C, Yucel B, Ozdemir O, Cetin M. Comparison of two misoprostol regimens for mid-trimester pregnancy terminations after FIGO's misoprostol dosage recommendation in 2012. J Matern Fetal Neonatal Med. 2016;29(8):1314-7. doi:10.3109/14767058.2015.1046825. [Google Scholar][Crossref]
  8. El-Gharib MN, Elebyary MT. Low-dose vaginal misoprostol in the management of intrauterine fetal death. J Matern Fetal Neonatal Med. 2011;24(10):1239-42. doi:10.3109/14767058.2010.547963. [Google Scholar][Crossref]
  9. Bracken H, Dabash R, Tsertsvadze G, Posohova S, Shah M, Hajri S, et al. Buccal misoprostol for treatment of fetal death at 14-28 weeks of pregnancy: a double-blind randomized controlled trial. Contraception. 2014;89(3):187-92. doi:10.1016/j.contraception.2013.11.009. [Google Scholar][Crossref]
  10. Cleeve A, Fonhus MS, Lavelanet A. A systematic review of the effectiveness, safety, and acceptability of medical management of intrauterine fetal death at 14-28 weeks of gestation. Int J Gynaecol Obstet. 2019;147(3):301-12. doi:10.1002/ijgo.12951. [Google Scholar][Crossref]
  11. Ministry of Health. Stillbirth. In: National guidelines on reproductive health services. Ministry of Health; 2016. p. 125-7. [Google Scholar][Crossref]
  12. United Nations Inter-agency Group for Child Mortality Estimation. A neglected tragedy: the global burden of stillbirths. New York: UNICEF; 2020. [Google Scholar][Crossref]
  13. Vo Thi Thanh Huyen. Evaluation of the effectiveness of misoprostol in the management of first and second trimester intrauterine fetal death [Specialist Thesis Level II]. Hue University of Medicine and Pharmacy; 2024. [Google Scholar][Crossref]
  14. Pham Thi Linh, Truong My Ngoc, Le Thi My Tien. Evaluation of the outcomes of pregnancy termination with misoprostol at 13 to 22 weeks of gestation at Can Tho City Obstetrics Hospital [Institution-Level Research Project]. Can Tho City Obstetrics Hospital; 2018. [Google Scholar][Crossref]

How to Cite

Nga, M. T. (2025). The Treatment Results Stillbirth in the Second and Third Trimesters by Misoprostol. International Journal of Medical and All Body Health Research, 6(3), 13-16. https://doi.org/10.54660/IJMBHR.2025.6.3.13-16

Nga, Mai Thi. "The Treatment Results Stillbirth in the Second and Third Trimesters by Misoprostol." International Journal of Medical and All Body Health Research, vol. 6, no. 3, 2025, pp. 13-16. https://doi.org/10.54660/IJMBHR.2025.6.3.13-16.

Nga, M. T. (2025) 'The Treatment Results Stillbirth in the Second and Third Trimesters by Misoprostol', International Journal of Medical and All Body Health Research, 6(3), pp. 13-16. doi: 10.54660/IJMBHR.2025.6.3.13-16.

Nga MT. The Treatment Results Stillbirth in the Second and Third Trimesters by Misoprostol. International Journal of Medical and All Body Health Research. 2025;6(3):13-16. doi:10.54660/IJMBHR.2025.6.3.13-16

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