International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

Current Issues
     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Association of Protein Glycosylation Disorders with Human Diabetes Diseases

Alaa Saeed Sheet, Amna Yarub Hameed

Department of Radiology Techniques, Mosul Medical Technical Institute, Northern Technical University, Iraq

Article Information

Volume / Issue6 / 2 (April-June 2025)
Pages143-151
AccessOpen Access

Publication Timeline

  • Received22 April 2025
  • Accepted23 May 2025

Full Text (PDF)

Open Access - Free to Download

Download Full Article (PDF) JATS XML

Abstract

Glycosylation is a vital post-translational modification crucial for protein function, folding, and stability. Disorders of protein glycosylation have significant implications for human diseases, including diabetes mellitus. This review explores the biological mechanisms underpinning protein glycosylation, types of glycosylation disorders, and their clinical manifestations, focusing on their association with diabetes. Recent studies demonstrate shared molecular pathways between glycosylation disorders and diabetes pathophysiology, emphasizing oxidative stress, inflammation, and impaired insulin signaling. Understanding these links offers prospects for novel diagnostic strategies and therapeutic interventions. Continuous research into the molecular crosstalk between glycosylation and glucose metabolism is essential for developing precision medicine approaches to manage diabetes and related complications.

Keywords

DiabetesDisordersProteinand Pathophysiology

References

  1. Keser T, Gornik I, Vučković F, Selak N, Pavić T, Lukić E, et al. Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes. Biochim Biophys Acta Gen Subj. 2017;1861(9):2243–51. DOI: 10.1016/j.bbagen.2017.06.020. [Google Scholar][Crossref]
  2. Naseri R, Navabi SJ, Samimi Z, Mishra AP, Nigam M, Chandra H, et al. Targeting glycoproteins as a therapeutic strategy for diabetes mellitus and its complications. Daru. 2020;28(2):707–24. DOI: 10.1007/s40199-020-00381-6. [Google Scholar][Crossref]
  3. Pasala C, Sharma S, Roychowdhury T, Moroni E, Colombo G, Chiosis G. N-glycosylation as a modulator of protein conformation and assembly in disease. Biomolecules. 2024;14(1):102. DOI: 10.3390/biom14010102. [Google Scholar][Crossref]
  4. Sparks SE. Congenital disorders of glycosylation. Adv Pediatr. 2012;59(1):285 –302. DOI: 10.1016/j.yapd.2012.04.003. [Google Scholar][Crossref]
  5. Goreta SS, Dabelic S, Dumic J. Insights into complexity of congenital disorders of glycosylation. Biochem Med (Zagreb). 2012;22(2):156–70. DOI: 10.11613/BM.2012.019. [Google Scholar][Crossref]
  6. Gümüş E, Özen H. Glycogen storage diseases: An update. World J Clin Pediatr. 2023;12(5):293–308. DOI: 10.5409/wjcp.v12.i5.293. [Google Scholar][Crossref]
  7. Andjelkovic M, Skakic A, Ugrin M, Spasovski V, Klaassen K, Pavlovic S, et al. Crosstalk between glycogen-selective autophagy, autophagy and apoptosis as a road towards modifier gene discovery and new therapeutic strategies for glycogen storage diseases. Front Genet. 2022;13:1021028. DOI: 10.3389/fgene.2022.1021028. [Google Scholar][Crossref]
  8. Mahjabeen W. Diabetes mellitus and its laboratory diagnosis. J Pak Med Assoc. 2018;68(7):1089–94. [Google Scholar][Crossref]
  9. Crist C. Insulin resistance due to obesity. Nat Educ. 2015;8(1):1. [Google Scholar][Crossref]
  10. Du C, Whiddett RO, Buckle I, Chen C, Forbes JM, Fotheringham AK. Advanced glycation end products and inflammation in type 1 diabetes development. Cells. 2022;11(21):3503. DOI: 10.3390/cells11213503. [Google Scholar][Crossref]
  11. Bolanle IO, Palmer TM. Targeting protein O-GlcNAcylation, a link between type 2 diabetes mellitus and inflammatory disease. Cells. 2022;11(4):704. DOI: 10.3390/cells11040704. [Google Scholar][Crossref]
  12. Wada Y. Matrix-assisted laser desorption/ionization mass spectrometry to detect diagnostic glycopeptide markers of congenital disorders of glycosylation. Mass Spectrom (Tokyo) . 2020;9(1):A0084. DOI: 10.5702/massspectrometry.A0084. [Google Scholar][Crossref]
  13. Ding Y, Li N, Lou D, Zhang Q, Chang G, Li J, et al. Clinical and genetic analysis in a Chinese cohort of children and adolescents with diabetes/persistent hyperglycemia. Front Endocrinol (Lausanne). 2021;12:653283. DOI: 10.3389/fendo.2021.653283. [Google Scholar][Crossref]
  14. Carmichael AG, Hulswit BB, Moe EJ, Jayaratne TE, International Journal of Medical and All Body Health Research www.allmedicaljournal.com Yashar BM. A qualitative study of anticipated decision making around type 2 diabetes genetic testing: the role of scientifically concordant and discordant expectations. J Genet Couns. 2017;26(6):1308–18. DOI: 10.1007/s10897-017-0113-8. [Google Scholar][Crossref]
  15. Brasil S, Pascoal C, Francisco R, Marques-da-Silva D, Andreotti G, Videira PA, et al. CDG therapies: From bench to bedside. Int J Mol Sci. 2018;19(5):1304. DOI: 10.3390/ijms19051304. [Google Scholar][Crossref]
  16. Sena CM, Bento CF, Pereira P, Marques F, Seiça R. Diabetes mellitus: New challenges and innovative therapies. EPMA J. 2013;4(1):11. DOI: 10.1186/1878-5085-4-11. [Google Scholar][Crossref]
  17. Sharma C, Hamza A, Boyle E, Donu D, Cen Y. Post-translational modifications and diabetes. Biomolecules. 2024;14(2):219. DOI: 10.3390/biom14020219. [Google Scholar][Crossref]

How to Cite

Sheet, A. S., & Hameed, A. Y. (2025). Association of Protein Glycosylation Disorders with Human Diabetes Diseases. International Journal of Medical and All Body Health Research, 6(2), 143-151. https://doi.org/10.54660/IJMBHR.2025.6.2.143-151

Sheet, Alaa Saeed, and Amna Yarub Hameed. "Association of Protein Glycosylation Disorders with Human Diabetes Diseases." International Journal of Medical and All Body Health Research, vol. 6, no. 2, 2025, pp. 143-151. https://doi.org/10.54660/IJMBHR.2025.6.2.143-151.

Sheet, A. S. and Hameed, A. Y. (2025) 'Association of Protein Glycosylation Disorders with Human Diabetes Diseases', International Journal of Medical and All Body Health Research, 6(2), pp. 143-151. doi: 10.54660/IJMBHR.2025.6.2.143-151.

Sheet AS, Hameed AY. Association of Protein Glycosylation Disorders with Human Diabetes Diseases. International Journal of Medical and All Body Health Research. 2025;6(2):143-151. doi:10.54660/IJMBHR.2025.6.2.143-151

Similar Articles

Share

Find this Article on

Google Scholar Semantic Scholar OpenAlex Scilit Crossref ResearchGate BASE

A newly published article may take a few days to appear on these services.