International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

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     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Impact of Early Treatment on Healthcare Utilization and Risk of Osteoarthritis in Psoriasis Patients

Article Information

Volume / Issue5 / 4 (October-December 2024)
Pages72-77
AccessOpen Access

Publication Timeline

  • Received05 September 2024
  • Accepted06 October 2024

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Abstract

Background: Psoriasis is a chronic immune-mediated inflammatory disorder with systemic implications, often leading to comorbidities such as psoriatic arthritis (PsA). Delayed treatment can exacerbate disease progression and increase healthcare utilization.

Objectives: This retrospective cohort study aims to evaluate the impact of early treatment initiation on healthcare utilization among psoriasis patients and explore the association between psoriasis and the risk of developing osteoarthritis (OA).

Methods: The study utilized de-identified patient data from TriNetX spanning a 10-year period (2013-2023). Psoriasis patients were grouped by age and categorized based on the timing of treatment initiation (within 90, 91-180, 181-270, and 271-365 days post-diagnosis). Healthcare utilization was analyzed, including ambulatory, emergency, and inpatient visits. Additionally, the incidence of OA among psoriasis patients was compared to a control group without underlying illnesses.

Results: Delayed treatment initiation was associated with significantly increased healthcare utilization across all age groups. Patients who received treatment within 90 days post-diagnosis had lower healthcare utilization compared to those who delayed treatment. Furthermore, patients with psoriasis demonstrated a higher incidence of OA compared to the control group, indicating a potential shared inflammatory mechanism between the two conditions.

Conclusions: Early treatment of psoriasis reduces healthcare utilization and may help mitigate disease progression and associated comorbidities, including OA. Proactive management strategies are crucial in reducing the burden on healthcare systems and improving long-term patient outcomes. Further research into shared inflammatory pathways between psoriasis and OA is warranted to develop targeted therapies.

References

  1. Nair PA, Badri T. Psoriasis. [Updated 2023 Apr 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; c2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK448194/ [Google Scholar][Crossref]
  2. Raharja A, Mahil SK, Barker JN. Psoriasis: a brief overview. Clin Med (Lond). 2021;21(3):170-173. doi: 10.7861/clinmed.2021-0257. PMID: 34001566; PMCID: PMC8140694. [Google Scholar][Crossref]
  3. Rendon A, Schäkel K. Psoriasis Pathogenesis and Treatment. Int J Mol Sci. 2019;20(6):1475. doi: 10.3390/ijms20061475. PMID: 30909615; PMCID: PMC6471628. [Google Scholar][Crossref]
  4. Kim WB, Jerome D, Yeung J. Diagnosis and management of psoriasis. Can Fam Physician. 2017;63(4):278-285. PMID: 28404701; PMCID: PMC5389757. [Google Scholar][Crossref]
  5. Kimmel GW, Lebwohl M. Psoriasis: Overview and Diagnosis. Evidence-Based Psoriasis. 2018 Jul 1:1–16. doi: 10.1007/978-3-319-90107-7_1. PMCID: PMC7122924. [Google Scholar][Crossref]
  6. Armstrong AW, Mehta MD, Schupp CW, Gondo GC, Bell SJ, Griffiths CEM. Psoriasis Prevalence in Adults International Journal of Medical and All Body Health Research www.allmedicaljournal.com in the United States. JAMA Dermatol. 2021;157(8):940-946. doi: 10.1001/jamadermatol.2021.2007. PMID: 34190957; PMCID: PMC8246333. [Google Scholar][Crossref]
  7. Merola JF, Dennis N, Chakravarty SD, et al. Healthcare utilization and costs among patients with psoriasis and psoriatic arthritis in the USA–a retrospective study of claims data from 2009 to 2020. Clin Rheumatol. 2021;40:4061–4070. https://doi.org/10.1007/s10067-021-05713-8 [Google Scholar][Crossref]
  8. Bhosle MJ, Kulkarni A, Feldman SR, Balkrishnan R. Quality of life in patients with psoriasis. Health Qual Life Outcomes. 2006 Jun 6;4:35. doi: 10.1186/1477-7525-4-35. PMID: 16756666; PMCID: PMC1501000. [Google Scholar][Crossref]
  9. Boehncke WH, Menter A. Burden of Disease: Psoriasis and Psoriatic Arthritis. Am J Clin Dermatol. 2013;14:377–388. https://doi.org/10.1007/s40257-013-0032-x [Google Scholar][Crossref]
  10. Zhou X, Chen Y, Cui L, et al. Advances in the pathogenesis of psoriasis: from keratinocyte perspective. Cell Death Dis. 2022;13:81. https://doi.org/10.1038/s41419-022-04523-3 [Google Scholar][Crossref]
  11. O’Neill TW, Felson DT. Mechanisms of Osteoarthritis (OA) Pain. Curr Osteoporos Rep. 2018;16:611–616. https://doi.org/10.1007/s11914-018-0477-1 [Google Scholar][Crossref]
  12. Chen D, Shen J, Zhao W, et al. Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res. 2017;5:16044. Copyright and License © The Author(s). Authors retain the copyright of their published articles. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution Non Commercial-Share A like 4.0 International (CC BY-NC-SA 4.0) License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. [Google Scholar][Crossref]

How to Cite

Basharat, R. (2024). Impact of Early Treatment on Healthcare Utilization and Risk of Osteoarthritis in Psoriasis Patients. International Journal of Medical and All Body Health Research, 5(4), 72-77.

Basharat, Rehman. "Impact of Early Treatment on Healthcare Utilization and Risk of Osteoarthritis in Psoriasis Patients." International Journal of Medical and All Body Health Research, vol. 5, no. 4, 2024, pp. 72-77.

Basharat, R. (2024) 'Impact of Early Treatment on Healthcare Utilization and Risk of Osteoarthritis in Psoriasis Patients', International Journal of Medical and All Body Health Research, 5(4), pp. 72-77.

Basharat R. Impact of Early Treatment on Healthcare Utilization and Risk of Osteoarthritis in Psoriasis Patients. International Journal of Medical and All Body Health Research. 2024;5(4):72-77.

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