International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

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     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Antibiotic classification, mechanisms, and indications: A review

Mohammed F Haddad, Basima A Abdullah, Hassan AA AlObeidi, Ali M Saadi, Mustafa F Haddad

Medical Laboratory Techniques Department / Mosul Medical Technical Institute / Northern Technical University/ Mosul/ Iraq; Dept. of Biology /College of Science/University of Mosul/ Mosul/ Iraq; M.Sc. Bacteriology, Mosul General Hospital, Mosul Iraq Department of Anesthesia, Iraq; Techniques, Mosul Medical Technical Institute, Northern Technical University, Mosul, Iraq

Article Information

Volume / Issue5 / 3 (July-September 2024)
Pages39-46
AccessOpen Access

Publication Timeline

  • Received02 June 2024
  • Accepted07 July 2024

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Abstract

An antibiotic was originally a material created by one microorganism that selectively inhibits another’s development. Since then, synthetic antibiotics have been developed that perform comparable tasks, typically chemically similar to natural antibiotics. There are no effects of antibiotics on viral infections. Antibiotics are used to treat bacterial infections in humans and animals. Several proposed classifications of antibiotics including chemical structure, mode of action, or organism of inhibitory activity. Most of the classification systems include two primary categories, the first categorizing based on chemical structure and the second categorizing based on the mechanism of action. Depending on their action, antibiotics are classified into bactericidal or bacteriostatic agents. Bactericidal agents kill or destroy the bacteria in the infected tissue; examples of bactericidal agents include penicillin, cephalosporins, fluoroquinolones, and aminoglycosides. Bacteriostatic agents cease bacterial multiplication, allowing other mechanisms of the immune system to kill the microbes. The antibacterial actions of antibiotics include inhibiting the bacterial cell wall, interrupting protein synthesis, plowing down the bacterial nucleic acid (DNA/RNA), inhibiting the biochemical metabolism, chelating metallic cations that are necessary for bacterial growth, and impairing the bacterial membranes by disintegrating it.

Keywords

antibioticpenicillincarbapenemLPS

References

  1. Abushaheen MA, Fatani AJ, Alosaimi M, Mansy W, George M, Acharya S, Jhugroo P. Antimicrobial resistance, mechanisms and its clinical significance. Disease-a-Month. 2020;66(6):100971. Available from: academia.edu [Google Scholar][Crossref]
  2. Acharya PC, Kurosu M. Medicinal chemistry of chemotherapeutic agents: a comprehensive resource of anti-infective and anti-cancer drugs; c2023. [HTML] [Google Scholar][Crossref]
  3. Adaji JA, Akaba GO, Isah AY, Yunusa T. Short versus long-term antibiotic prophylaxis in cesarean section: a randomized clinical trial. Nigerian Medical Journal. 2020. Available from: ajol.info; c2020. [Google Scholar][Crossref]
  4. Aguirre Rivera J, Larsson J, Volkov IL, Seefeldt AC, Sanyal S, Johansson M. Real-time measurements of aminoglycoside effects on protein synthesis in live cells. Proceedings of the National Academy of Sciences; 2021:118(9). Available from: pnas.org International Journal of Medical and All Body Health Research www.allmedicaljournal.com [Google Scholar][Crossref]
  5. Ahmadi MH. Global status of tetracycline resistance among clinical isolates of Vibrio cholerae: a systematic review and meta-analysis. Antimicrobial Resistance & Infection Control. 2021. Available from: springer.com [Google Scholar][Crossref]
  6. Alavi M, Hamblin MR. Antibacterial silver nanoparticles: effects on bacterial nucleic acids. Cellular, Molecular and Biomedical Reports. 2023;3(1):35-40. Available from: cmbr-journal.com [Google Scholar][Crossref]
  7. Anandabaskar N. Protein synthesis inhibitors. In: Introduction to Basics of Pharmacology and Toxicology: Volume 2: Essentials of Systemic Pharmacology: From Principles to Practice. 2021. p. 835-868. [HTML] [Google Scholar][Crossref]
  8. Arguedas A, Trzciński K, O’Brien KL, Ferreira DM, Wyllie AL, Weinberger D, Gessner BD. Upper respiratory tract colonization with Streptococcus pneumoniae in adults. Expert Review of Vaccines. 2020;19(4):353-366. Available from: lstmed.ac.uk [Google Scholar][Crossref]
  9. Baquero F, Levin BR. Proximate and ultimate causes of the bactericidal action of antibiotics. Nature Reviews Microbiology. 2021. Available from: nature.com [Google Scholar][Crossref]
  10. Bessa G. Bacterial infections. In: Dermatology in Public Health Environments: A Comprehensive Textbook. Cham: Springer International Publishing; 2023. p. 183-202. [HTML] [Google Scholar][Crossref]
  11. Bhattacharjee MK. Antibiotics that inhibit cell wall synthesis. In: Chemistry of Antibiotics and Related Drugs. 2022. [HTML] [Google Scholar][Crossref]
  12. Bu Y, Hu Q, Bao T, Xie X, Wang S. Recent advances in cell membrane-coated technology for drug discovery from natural products. TrAC Trends in Analytical Chemistry. 2022. [HTML] [Google Scholar][Crossref]
  13. Cook MA, Wright GD. The past, present, and future of antibiotics. Science Translational Medicine. 2022. [HTML] [Google Scholar][Crossref]
  14. Czajkowski K, Broś-Konopielko M, Teliga-Czajkowska J. Urinary tract infection in women. Menopause Review/Przegląd Menopauzalny. 2021;20(1):40-47. Available from: termedia.pl [Google Scholar][Crossref]
  15. Dighe SN, Collet TA. Recent advances in DNA gyrase-targeted antimicrobial agents. European Journal of Medicinal Chemistry. 2020. [HTML] [Google Scholar][Crossref]
  16. Dutta D, Kaushik A, Kumar D, Bag S. Foodborne pathogenic vibrios: antimicrobial resistance. Frontiers in Microbiology. 2021. Available from: frontiersin.org [Google Scholar][Crossref]
  17. Feldman C, Anderson R. The role of Streptococcus pneumoniae in community-acquired pneumonia. In: Seminars in Respiratory and Critical Care Medicine. Thieme Medical Publishers; 2020. 41(4):455-469. Available from: up.ac.za [Google Scholar][Crossref]
  18. Frei A, Verderosa AD, Elliott AG, Zuegg J, Blaskovich MA. Metals to combat antimicrobial resistance. Nature Reviews Chemistry. 2023;7(3):202-224. Available from: nature.com [Google Scholar][Crossref]
  19. Gallagher JC, MacDougall C. Antibiotics Simplified. 2022. Available from: jbpub.com [Google Scholar][Crossref]
  20. Giovannoni M, Gramegna G, Benedetti M, Mattei B. Industrial use of cell wall degrading enzymes: the fine line between production strategy and economic feasibility. Frontiers in Bioengineering and Biotechnology. 2020;8:356. Available from: frontiersin.org [Google Scholar][Crossref]
  21. Graham NC. A broad spectrum of opportunities− the history of the Bayer company and the evolution of antibiotics 1945−1990. 2023. Available from: uio.no [Google Scholar][Crossref]
  22. Greydanus DE, Cates KW, Sadigh N. Pelvic inflammatory disease. In: Sexually Transmitted Infections in Adolescence and Young Adulthood: A Practical Guide for Clinicians. 2020. p. 69-86. [HTML] [Google Scholar][Crossref]
  23. Grishin AV, Karyagina AS, Vasina DV, Vasina IV, Gushchin VA, Lunin VG. Resistance to peptidoglycan-degrading enzymes. Critical Reviews in Microbiology. 2020;46(6):703-726. [HTML] [Google Scholar][Crossref]
  24. World Health Organization. Guidelines for the management of symptomatic sexually transmitted infections. 2021. Available from: google.com [Google Scholar][Crossref]
  25. World Health Organization. WHO operational handbook on tuberculosis. Module 4: treatment-drug-susceptible tuberculosis treatment. 2021. Available from: google.com [Google Scholar][Crossref]
  26. Horváth A, Dobay O, Sahin-Tóth J, Juhász E, Pongrácz J, Iván M, Kristóf K. Characterisation of antibiotic resistance, virulence, clonality and mortality in MRSA and MSSA bloodstream infections at a tertiary-level hospital in Hungary: a 6-year retrospective study. Annals of Clinical Microbiology and Antimicrobials. 2020;19:1-11. Available from: springer.com [Google Scholar][Crossref]
  27. Iturriza-Gómara M, Cunliffe NA. Viral gastroenteritis. In: Hunter's Tropical Medicine and Emerging Infectious Diseases. Elsevier; 2020. p. 289-307. [HTML] [Google Scholar][Crossref]
  28. Kim D, Kim S, Kwon Y, Kim Y, Park H, Kwak K, Kang LW. Structural insights for β-lactam antibiotics. Biomolecules & Therapeutics. 2023;31(2):141. Available from: nih.gov [Google Scholar][Crossref]
  29. Kirsch SH, Haeckl FPJ, Müller R. Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi. Natural Product Reports. 2022. [HTML] [Google Scholar][Crossref]
  30. Klein EY, Milkowska-Shibata M, Tseng KK, Sharland M, Gandra S, Pulcini C, Laxminarayan R. Assessment of WHO antibiotic consumption and access targets in 76 countries, 2000–15: an analysis of pharmaceutical sales data. The Lancet Infectious Diseases. 2021;21(1):107-115. Available from: sgul.ac.uk [Google Scholar][Crossref]
  31. Konwar M, Gogtay NJ, Ravi R, Thatte UM, Bose D. Evaluation of efficacy and safety of fosfomycin versus nitrofurantoin for the treatment of uncomplicated lower urinary tract infection (UTI) in women–a systematic review and meta-analysis. Journal of Chemotherapy. 2022;34(3):139-148. [HTML] [Google Scholar][Crossref]
  32. Lade H, Kim JS. Bacterial targets of antibiotics in Methicillin-Resistant Staphylococcus aureus. Antibiotics. 2021. Available from: mdpi.com [Google Scholar][Crossref]
  33. Lalchhandama K. History of penicillin. WikiJournal of Medicine. 2021. Available from: informit.org [Google Scholar][Crossref]
  34. Li ZJ, Zhang HY, Ren LL, Lu QB, Ren X, Zhang CH, Yang WZ. Etiological and epidemiological features of acute respiratory infections in China. Nature Communications. 2021;12(1):5026. Available from: nature.com [Google Scholar][Crossref]
  35. Lima LM, da Silva BNM, Barbosa G, Barreiro EJ. β-lactam antibiotics: an overview from a medicinal chemistry perspective. European Journal of Medicinal Chemistry. 2020;208:112829. [HTML] [Google Scholar][Crossref]
  36. MacInnes JI, Van Immerseel F, Boyce JD, Rycroft AN, Vázquez-Boland JA. Pathogenesis of bacterial infections in animals. In: Prescott JF, editor. John Wiley & Sons, Incorporated; 2022. [HTML] [Google Scholar][Crossref]
  37. Mohammed SO, Shuaibu SDA, Gaya SA, Rabiu A. The International Journal of Medical and All Body Health Research www.allmedicaljournal.com efficacy of two doses versus 7 days’ course of prophylactic antibiotics following cesarean section: an experience from Aminu Kano Teaching Hospital. Annals of African Medicine. 2020;19(2):103-112. Available from: lww.com [Google Scholar][Crossref]
  38. Nguyen NV, Do NTT, Nguyen CTK, Tran TK, Ho PD, Nguyen HH, Lewycka S. Community-level consumption of antibiotics according to the AWaRe (Access, Watch, Reserve) classification in rural Vietnam. JAC-Antimicrobial Resistance. 2020;2(3). Available from: oup.com [Google Scholar][Crossref]
  39. Oliveira I, Rego C, Semedo G, Gomes D, Figueiras A, Roque F, Herdeiro MT. A systematic review on the impact of guidelines adherence on antibiotic prescription in respiratory infections. Antibiotics. 2020;9(9):546. Available from: mdpi.com [Google Scholar][Crossref]
  40. Peloquin CA, Davies GR. The treatment of tuberculosis. Clinical Pharmacology & Therapeutics. 2021;110(6):1455-1466. Available from: researchgate.net [Google Scholar][Crossref]
  41. Prasad R, Singh A, Gupta N. Adverse drug reactions with first-line and second-line drugs in treatment of tuberculosis. Annals of the National Academy of Medical Sciences (India). 2021;57(01):15-35. Available from: thieme-connect.com [Google Scholar][Crossref]
  42. Ramachanderan R, Schaefer B. Tetracycline antibiotics. ChemTexts. 2021. Available from: springer.com [Google Scholar][Crossref]
  43. Rao CD. Enteroviruses in gastrointestinal diseases. Reviews in Medical Virology. 2021. [HTML] [Google Scholar][Crossref]
  44. Riu F, Ruda A, Ibba R, Sestito S, Lupinu I, Piras S, Carta A. Antibiotics and carbohydrate-containing drugs targeting bacterial cell envelopes: an overview. Pharmaceuticals. 2022;15(8):942. Available from: mdpi.com [Google Scholar][Crossref]
  45. Rohs PDA, Bernhardt TG. Growth and division of the peptidoglycan matrix. Annual Review of Microbiology. 2021. [HTML] [Google Scholar][Crossref]
  46. Sahoo BM, Banik BK. Therapeutic potentials of β‐ lactam: a scaffold for new drug development. In: Synthetic Approaches to Nonaromatic Nitrogen Heterocycles. 2020. p. 59-88. Available from: researchgate.net [Google Scholar][Crossref]
  47. Satoskar RS, Bhandarkar SD. Pharmacology and Pharmacotherapeutics. 2020. [HTML] [Google Scholar][Crossref]
  48. Singhal M, Agrawal M, Bhavna K, Sethiya NK, Bhargava S, Gondkar KS, Arora MK. Chloramphenicol and tetracycline (broad spectrum antibiotics). In: Antibiotics-Therapeutic Spectrum and Limitations. Academic Press; 2023. p. 155-165. [HTML] [Google Scholar][Crossref]
  49. Spencer AC, Panda SS. DNA gyrase as a target for quinolones. Biomedicines. 2023. Available from: mdpi.com [Google Scholar][Crossref]
  50. Szlasa W, Zendran I, Zalesińska A, Tarek M, Kulbacka J. Lipid composition of the cancer cell membrane. Journal of Bioenergetics and Biomembranes. 2020;52(5):321-342. Available from: springer.com [Google Scholar][Crossref]
  51. Tietel M, Shema-Didi L, Roth R, Wolf MF, Bornstein J. Compliance with a new quality standard regarding administration of prophylactic antibiotics before cesarean section. The Journal of Maternal-Fetal & Neonatal Medicine. 2022;35(25):6243-6249. [HTML] [Google Scholar][Crossref]
  52. Tutone M, Johansen TEB, Cai T, Mushtaq S, Livermore DM. Susceptibility and resistance to fosfomycin and other antimicrobial agents among pathogens causing lower urinary tract infections: findings of the SURF study. International Journal of Antimicrobial Agents. 2022;59(5):106574. Available from: sciencedirect.com [Google Scholar][Crossref]
  53. Uddin TM, Chakraborty AJ, Khusro A, Zidan BRM, Mitra S, Emran TB, Koirala N. Antibiotic resistance in microbes: history, mechanisms, therapeutic strategies and future prospects. Journal of Infection and Public Health. 2021;14(12):1750-1766. Available from: sciencedirect.com [Google Scholar][Crossref]
  54. Urban-Chmiel R, Marek A, Stępień-Pyśniak D, Wieczorek K, Dec M, Nowaczek A, Osek J. Antibiotic resistance in bacteria—A review. Antibiotics. 2022;11(8):1079. Available from: mdpi.com [Google Scholar][Crossref]
  55. Varela MF, Stephen J, Lekshmi M, Ojha M, Wenzel N, Sanford LM, Kumar SH. Bacterial resistance to antimicrobial agents. Antibiotics. 2021;10(5):593. Available from: mdpi.com [Google Scholar][Crossref]
  56. Wang Z. The Chemistry and Biology of Beta-Lactams. 2023. [HTML] [Google Scholar][Crossref]
  57. Wang Z, Sun Q, Zhang H, Wang J, Fu Q, Qiao H, Wang Q. Insight into antibacterial mechanism of polysaccharides: a review. LWT. 2021;150:111929. [HTML] [Google Scholar][Crossref]
  58. Wilson DN, Hauryliuk V, Atkinson GC, O’Neill AJ. Target protection as a key antibiotic resistance mechanism. Nature Reviews Microbiology. 2020;18(11):637-648. Available from: whiterose.ac.uk [Google Scholar][Crossref]
  59. Workowski KA. Sexually transmitted infections treatment guidelines, 2021. MMWR. Recommendations and Reports. 2021. Available from: cdc.gov [Google Scholar][Crossref]
  60. Yueh CM, Chi H, Chiu NC, Huang FY, Huang DTN, Chang L, Huang CY. Etiology, clinical features, management, and outcomes of skin and soft tissue infections in hospitalized children: a 10-year review. Journal of Microbiology, Immunology and Infection. 2022;55(4):728-739. Available from: sciencedirect.com [Google Scholar][Crossref]
  61. Zhang F, Cheng W. The mechanism of bacterial resistance and potential bacteriostatic strategies. Antibiotics. 2022. Available from: mdpi.com [Google Scholar][Crossref]
  62. Zheng Y, Zhu X, Jiang M, Cao F, You Q, Chen X. Development and applications of D‐amino acid derivatives‐based metabolic labeling of bacterial peptidoglycan. Angewandte Chemie. 2024;136(17). [HTML] Copyright and License © The Author(s). Authors retain the copyright of their published articles. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution Non Commercial-Share A like 4.0 International (CC BY-NC-SA 4.0) License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. [Google Scholar][Crossref]

How to Cite

Haddad, M. F., Abdullah, B. A., AlObeidi, H. A. A., Saadi, A. M., & Haddad, M. F. (2024). Antibiotic classification, mechanisms, and indications: A review. International Journal of Medical and All Body Health Research, 5(3), 39-46. https://doi.org/10.54660/IJMBHR.2024.5.3.39-46

Haddad, Mohammed F, et al. "Antibiotic classification, mechanisms, and indications: A review." International Journal of Medical and All Body Health Research, vol. 5, no. 3, 2024, pp. 39-46. https://doi.org/10.54660/IJMBHR.2024.5.3.39-46.

Haddad, M. F., Abdullah, B. A., AlObeidi, H. A. A., Saadi, A. M. and Haddad, M. F. (2024) 'Antibiotic classification, mechanisms, and indications: A review', International Journal of Medical and All Body Health Research, 5(3), pp. 39-46. doi: 10.54660/IJMBHR.2024.5.3.39-46.

Haddad MF, Abdullah BA, AlObeidi HAA, Saadi AM, Haddad MF. Antibiotic classification, mechanisms, and indications: A review. International Journal of Medical and All Body Health Research. 2024;5(3):39-46. doi:10.54660/IJMBHR.2024.5.3.39-46

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