Ntoum: A major focus of malaria in Gabon's Estuary province
Article Information
Publication Timeline
- Received15 March 2024
- Accepted16 April 2024
Abstract
Introduction: Malaria is a major public health problem in Gabon, and yet in some regions of the country, such as the administrative department of Komo-Mondah, data on malaria are scarce or lacking. The aim of this study was to describe the epidemiological and clinical characteristics of malaria patients in the commune of Ntoum (Komo-Mondah).
Methods: Socio-demographic and clinical characteristics were collected from 248 patients attending the clinical laboratory of Ntoum departmental hospital using a pre-established data collection form. After blood sampling in an EDTA tube, a haemogram and two blood smears (thin and thick) were performed on each blood sample by a laboratory technician.
Results: The prevalence of malaria was 78% (194/248), with Plasmodium falciparum identified as the main etiological agent. Those most at risk of malaria were children aged 0-5 years (43%, 83/194) followed by adults older thant 25 years (21%, 41/194), and female (62%, 120/194). Parasitemia ranged from 10 to 210,000 parasites/µL blood, and 73% (140/194) of parasite infections were associated with anemia. Most cases of anemia (83%, 118/140) were mild, 78% (110/140) microcytic anemia of which99 cases were hypochromic anemia.
Conclusion: This study has provided crucial information for understanding the occurrence of malaria and the infectious complications resulting from malaria infection in the Ntoum region. The data also reveal the absolute necessity of implementing targeted and sustainable health education programs for vulnerable groups.
References
- Lalremruata A, Jeyaraj S, Engleitner T, Joanny F, Lang A, Bélard S, Mombo-Ngoma G, Ramharter M, Kremsner PG, Mordmüller B, Held J: Species and genotype diversity of Plasmodium in malaria patients from Gabon analysed by next generation sequencing. Malar J. 2017; 16:398. [Google Scholar][Crossref]
- World Health Organization: World malaria report, 2023. [Google Scholar][Crossref]
- World Health Organization: World malaria report, 2022. [Google Scholar][Crossref]
- Direction Générale de la Statistique (DGS): Enquête Démographique et de Santé au Gabon, 2019-21. 2023; 1:691. [Google Scholar][Crossref]
- Direction Générale de la Statistique (DGS): Recensement général de la population et des logements de 2013 du Gabon. RGPL, 2013. [Google Scholar][Crossref]
- Lendongo-Wombo J-B, Oyegue- Liabagui S-L, Biteghe-Bi-Essone J-C, Ngoungou EB, Lekana-Douki J-B: Epidémiology of malaria from 2019 to 2021 in the southeastern city of Franceville, Gabon. BMC Public Health. 2022; 22:2313. [Google Scholar][Crossref]
- Boundenga L, Bignoumba M, Dibakou SE, Mombo LE, Moukagni- Mussadji CJ, Wora DM, Kassa-Kassa F, Bisseye C, Onanga R: Decrease on malaria clinical cases from 2017 to 2019 in Franceville, Southeast Gabon, Central Africa. J Public Health Afr. 2023; 14:1865. [Google Scholar][Crossref]
- Mourou JR, Coffinet T, Jarjaval F, Cotteaux C, Pradines E, Godefroy L, et al. Malaria transmission in Libreville: results of a one year survey. Malar J. 2012; 11:40. [Google Scholar][Crossref]
- Pamba R, Koumba AA, Zinga-Koumba CR, Kutomy POO, Ovono APM, Itsiembou LD, et al. Six years surveillance of Plasmodium falciparum malaria among febrile patients reporting in Centre de Santé d’Okala, North West Gabon. Microbes and Infectious Diseases. 2021; 2:823-830. [Google Scholar][Crossref]
- Kouna LC, Oyegue-Liabagui SL, Voumbo-Matoumona DF, Lekana-Douki JB. Malaria Prevalence in Asymptomatic and Symptomatic Children Living in Rural, Semi-Urban and Urban Areas in Eastern Gabon. Acta Parasitologica, 2024, 1- 12. [Google Scholar][Crossref]
- Bisseye C, Kombila A, Ndong Mba T, Ngossanga B, Moundounga Kenguele H. Prevalence of Malaria from Blood Smears: A Four-Year Retrospective Study from the Jean Claude Handrault Hospital, Southern Gabon. International Journal of Tropical Disease & Health. 2021; 42:1-7. [Google Scholar][Crossref]
- Imboumy-Limoukou RK, Lendongo-Wombo JB, Nguimbyangue-Apangome AF, Biteghe Bi Essone J-C, Mounioko F, Oyegue-Libagui LS, et al. Severe malaria in Gabon: epidemiological, clinical and laboratory features in Amissa Bongo Hospital of Franceville. Malaria Journal. 2023; 22:1-8. [Google Scholar][Crossref]
- Lendzele SS, Rodriquge MN, Boris M, Kutomy PO, Armel KA, Christophe Z-KR, Leotard SO, Mavoungou JF: Is malaria cases frequency correlated with the environmental and demographic composition at Mitzic medical center in Gabon? DYSONA-Life Science 2022, 3:41-48. [Google Scholar][Crossref]
- Ebigre JM, Et Marius C. Etude d'une séquence mangrove-tanne en milieu équatorial, baie de la mondah (GABON). Travaux et Documents de Géographie Tropicale CEGET, 1984. 2ème trimestre, n° 51 [Google Scholar][Crossref]
- Organization WH: Guidelines for the treatment of malaria. World Health Organization, 2015. [Google Scholar][Crossref]
- White NJ. Anaemia and malaria. Malar J. 2018; 17:371. [Google Scholar][Crossref]
- Nkhoma P, Loti P, Sinkala M, Mantina H, Mwaba F, Kafita D, et al. Anaemia Types and Severity in Patients aged 1 to 14 years at the Children’s Hospital of the University Teaching Hospitals in Zambia. Med Rxiv 2020:2020.2009. 2017.20194779. [Google Scholar][Crossref]
- Planche T, Krishna S, Kombila M, Engel K, Faucher J, Ngou-Milama E, et al. Comparison of methods for the rapid laboratory assessment of children with malaria. The American journal of tropical medicine and hygiene. 2001; 65:599-602. [Google Scholar][Crossref]
- Boudin C, Robert V, Gazin P. Évaluation épidémiologique des paludismes. [Google Scholar][Crossref]
- Organization WH. Report on the Malaria Conference in Equatorial Africa, held under the joint auspices of the World Health Organization and the Commission for Technical Co- operation in Africa South of the Sahara, Kampala, Uganda, 27 November-9 December 1950. World Health Organization; 1951. [Google Scholar][Crossref]
- Pegha Moukandja I, Biteghe Bi Essone JC, Sagara I, Kassa Kassa RF, Ondzaga J, Lékana Douki JB, Bouyou International Journal of Medical and All Body Health Research www.allmedicaljournal.com Akotet M, Nkoghe Mba D, Touré Ndouo FS. Marked Rise in the Prevalence of Asymptomatic Plasmodium falciparum Infection in Rural Gabon. PLoS One. 2016; 11:e0153899. [Google Scholar][Crossref]
- Maghendji-Nzondo S, Nzoughe H, Lemamy GJ, Kouna LC, Pegha- Moukandja I, Lekoulou F, Mbatchi B, Toure-Ndouo F, Lekana-Douki JB. Prevalence of malaria, prevention measures, and main clinical features in febrile children admitted to the Franceville Regional Hospital, Gabon. Parasite. 2016; 23. [Google Scholar][Crossref]
- Ajakaye OG, Ibukunoluwa MR. Prevalence and risk of malaria, anemia and malnutrition among children in IDPs camp in Edo State, Nigeria. Parasite Epidemiol Control. 2020; 8:e00127. [Google Scholar][Crossref]
- Makenga G, Menon S, Baraka V, Minja DT, Nakato S, Delgado-Ratto C, Francis F, Lusingu JP, Van Geertruyden JP. Prevalence of malaria parasitaemia in school- aged children and pregnant women in endemic settings of sub-Saharan Africa: a systematic review and meta-analysis. Parasite Epidemiol Control. 2020; 11:e00188. [Google Scholar][Crossref]
- Tsegaye AT, Ayele A, Birhanu S. Prevalence and associated factors of malaria in children under the age of five years in Wogera district, northwest Ethiopia: A cross-sectional study. PLoS One. 2021; 16:e0257944. [Google Scholar][Crossref]
- Duguay C, Mosha JF, Lukole E, Mangalu D, Thickstun C, Mallya E, Aziz T, Feng C, Protopopoff N, Mosha F. Assessing risk factors for malaria and schistosomiasis among children in Misungwi, Tanzania, an area of co-endemicity: A mixed methods study. PLOS Global Public Health. 2023; 3:e0002468. [Google Scholar][Crossref]
- Chilot D, Mondelaers A, Alem AZ, Asres MS, Yimer MA, Toni AT, Ayele TA. Pooled prevalence and risk factors of malaria among children aged 6–59 months in 13 sub-Saharan African countries: A multilevel analysis using recent malaria indicator surveys. PLoS One. 2023; 18:e0285265. [Google Scholar][Crossref]
- Drakeley C, Abdulla S, Agnandji ST, Fernandes JF, Kremsner P, Lell B, Mewono L, Bache BE, Mihayo MG, Juma O, et al. Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries. Malar J. 2017; 16:433. [Google Scholar][Crossref]
- Zoleko Manego R, Koehne E, Kreidenweiss A, Nzigou Mombo B, Adegbite BR, Dimessa Mbadinga LB, Akinosho M, Matthewman J, Adegnika AA, Ramharter M, Mombo-Ngoma G. Description of Plasmodium falciparum infections in central Gabon demonstrating high parasite densities among symptomatic adolescents and adults. Malar J. 2019; 18:371. [Google Scholar][Crossref]
- Nateghpour M, Hosseininasab A, Farrokhnia M, Dastouri F, Alidoosti K, Sadequi D, Ahmadi A. Species-dependent clinical findings of malaria caused by various plasmodia in an endemic area of Kerman Province, Southeastern Iran. Iranian J Public Health. 2017; 46:525. [Google Scholar][Crossref]
- Mosha JF, Sturrock HJW, Greenhouse B, Greenwood B, Sutherland CJ, Gadalla N, Atwal S, Drakeley C, Kibiki G, Bousema T, et al. Epidemiology of subpatent Plasmodium falciparum infection: implications for detection of hotspots with imperfect diagnostics. Malar J. 2013; 12:221. [Google Scholar][Crossref]
- Okell LC, Bousema T, Griffin JT, Ouédraogo AL, Ghani AC, Drakeley CJ. Factors determining the occurrence of submicroscopic malaria infections and their relevance for control. Nat Commun. 2012; 3:1237. [Google Scholar][Crossref]
- Bashawri LA, Mandil AA, Bahnassy AA, Ahmed MA. Malaria: hematological aspects. Ann Saudi Med. 2002; 22:372-376. [Google Scholar][Crossref]
- Cao H, Vickers MA. Oxidative Bashawri LA, Mandil AA, Bahnassy AA, Ahmed MA. Malaria: hematological aspects. Ann Saudi Med. 2002; 22:372-376. [Google Scholar][Crossref]
- Chao DL, Oron AP, Chabot-Couture G, Sopekan A, Nnebe-Agumadu U, Bates I, Piel FB, Nnodu O. Contribution of malaria and sickle cell disease to anaemia among children aged 6–59 months in Nigeria: a cross-sectional study using data from the 2018 Demographic and Health Survey. BMJ Open. 2022; 12:e063369. [Google Scholar][Crossref]
- Kotepui M, Piwkham D, PhunPhuech B, Phiwklam N, Chupeerach C, Duangmano S. Effects of malaria parasite density on blood cell parameters. PLoS One. 2015; 10:e0121057. [Google Scholar][Crossref]
- Nzabakiriraho JD, Gayawan E. Geostatistical modeling of malaria prevalence among under-five children in Rwanda. BMC Public Health. 2021; 21:1-11. [Google Scholar][Crossref]
- Rogier C, Commenges D, Trape JF. Evidence for an age-dependent pyrogenic threshold of Plasmodium falciparum parasitemia in highly endemic populations. Am J Trop Med Hyg. 1996; 54:613-619. [Google Scholar][Crossref]
- Newton CR, Krishna S. Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment. Pharmacol Ther. 1998; 79:1-53. [Google Scholar][Crossref]
- Agarwal P. Haematological Parameters in Malaria: A Clinico Patho [Google Scholar][Crossref]
- Diagne I, Fall A, Diagne-Gueye N, Déme-Ly I, Lopez-Sall P, Faye C, Sarr M, Camara B, Sow H. Hypochromic microcytic anaemia in pediatrics: Frequency and response to iron treatment. A study in outpatients in Albert Royer National Children Hospital of Dakar, Senegal. J Pediatr Pueric. 2010; 23:119-124 Copyright and License © The Author(s). Authors retain the copyright of their published articles. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution Non Commercial-Share A like 4.0 International (CC BY-NC-SA 4.0) License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. [Google Scholar][Crossref]
How to Cite
Meye, B., Alame-Emane, A. K., Ondo, J. P., Kenguele, H. M., Nkoghe, D., & Engonga, L. C. O. (2024). Ntoum: A major focus of malaria in Gabon's Estuary province. International Journal of Medical and All Body Health Research, 5(2), 07-14.
Meye, Bourdettes, et al. "Ntoum: A major focus of malaria in Gabon's Estuary province." International Journal of Medical and All Body Health Research, vol. 5, no. 2, 2024, pp. 07-14.
Meye, B., Alame-Emane, A. K., Ondo, J. P., Kenguele, H. M., Nkoghe, D. and Engonga, L. C. O. (2024) 'Ntoum: A major focus of malaria in Gabon's Estuary province', International Journal of Medical and All Body Health Research, 5(2), pp. 07-14.
Meye B, Alame-Emane AK, Ondo JP, Kenguele HM, Nkoghe D, Engonga LCO. Ntoum: A major focus of malaria in Gabon's Estuary province. International Journal of Medical and All Body Health Research. 2024;5(2):07-14.
Similar Articles
- The Knowledge, Attitude and Practice of Malaria Prevention among Women in Rural Communities of Jos East Local Government Area of Plateau State Vol 5, Issue 4 (2024)
- Prevalence of malaria infection in children aged 0-5 years, received at the Moanda medical centre: A retrospective study from 2021, in South-Eastern Gabon Vol 3, Issue 2 (2022)
- RP-HPLC Method Development and Validation for the Quantitative Determination of Ruxolitinib in Pure Form and Marketed Pharmaceutical Dosage Form Vol 5, Issue 2 (2024)
- Formulation and evaluation of metoprolol tartrate transdermal drug patches Vol 5, Issue 2 (2024)
- Formulation and evaluation of gastroretentive floating microspheres of nimodipine Vol 5, Issue 2 (2024)
Find this Article on
Google Scholar Semantic Scholar OpenAlex ResearchGate BASEA newly published article may take a few days to appear on these services.