International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

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     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Impact the prevalence of Mycobacterium tuberculosis in Erbil city

Fattma A Ali, Ahmed Akil Khudhair Al-Daoody, Bashdar Mahmud Hussen, Israa Khalil Salih, Israa Yassin Razaq, Zainaba Muhammad Abbas

College of Health Sciences/Hawler Medical University. Kurdistan Region, Erbil, Iraq; Department of Clinical Analysis, College of Pharmacy, Hawler Medical university, Kurdistan Region, Erbil, Iraq

Article Information

Volume / Issue4 / 1 (January-March 2023)
Pages54-59
AccessOpen Access

Publication Timeline

  • Received21 February 2023
  • Accepted25 March 2023

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Abstract

Background: Infection by Mycobacterium tuberculosis is a continuous problem in patient especially in developing country, due to its infectious nature, complex immunological response, chronic progression and the need for long-term treatment, TB has always been a major health burden; in more recent years, associated with its severe social implications, treating and preventing TB have represented a permanent challenge over the course of human history.
Objectives: Our study aimed to carry out a center-based cross sectional study on Mycobacterium tuberculosis isolated from January 2015 till November 2019, rate of Tuberculosis among age group, gender, site of infection and extra pulmonary sub- diagnosis.
Materials and Methods: Totally 1061 tuberculosis patients from January 2015 till November 2019. were collected from Chest and Respiratory Disease Center/Erbil-Iraq. Identified by using macroscopical, microscopical. Acid fast stain was performed, isolates were characterized by using Gene xpert. Sputum smear-positive tuberculosis (PTB) patients diagnosed were enrolled and then were cultured at Löwenstein–Jensen (LJ) medium. Statistical analysis was performed.
Results: A total of (1061) samples were collected from eight sources (abscess, peritoneal fluid, pleural effusion, spinal cord, sputum, tissue biopsy, urine), the number of cases increased from 2015 to 2019 distributed as 198(18.7%) positive cases in 2015, 196(18.5%) in 2016, 208(19.6%) in 2017, in 2018 238(22.4%) and 221(20.8%) in
2019. From 2015 to 2019 the percentage of males infected with M.tuberculosis were more than the females being 520/1061(49.0%) and males being 541/1061(50.9%,there was highly significant correlation (p < 0.0009) between bacteria and genders, infections by TB increased among age groups (25-34) being 207/1061(19.53%) and elderly patients(above 65) being 222/1061 (20.94%), there was significant correlation between bacteria and age group, (p<0.009) Cases of extra pulmonary tuberculosis 595(56.1%) were more than pulmonary tuberculosis infection 466(43.9%). Lymph nodes was major site of extra pulmonary tuberculosis infection being 189/595(31.8%) among all five years.
Conclusions: The study findings showed a significant distribution of tuberculosis which may increase the burden of healthcare-associated infections. Although is essential for the appropriate treatment of TB patients and the prevention of spread of drug-resistant strains. Moreover. New molecular tools are now used in many countries as part of a standard laboratory diagnosis. Nevertheless, there is still a lot to be done, especially in our country where fast identification and early treatment are needed. 
 

Keywords

Mycobacterium tuberculosisespeciallyErbil

References

  1. Asmar S, Drancourt M. Rapid culture-based diagnosis of pulmonary tuberculosis in developed and developing countries. Frontiers in Microbiology. 2015; 6:1184. [Google Scholar][Crossref]
  2. Brasil. Ministério da Saúde;. Departamento de Vigilância em Doenças Transmissíveis. Novas recomendações para tratamento da tuberculose multidrogarresistente e com resistência à rifampicina diagnosticada por meio do Teste Rápido Molecular para Tuberculose no Brasil. Nota informativa 8. Brasília: Ministério da Saúde. 2016; 46(2):e20190290. [Google Scholar][Crossref]
  3. Cepheid. 2020. Xpert® MTB/RIF [Online]. cepheid® Available: -MTB-RIF-ENGLISH Package-Insert-301-1404-Rev-G.pdf [Accessed July 2020]. [Google Scholar][Crossref]
  4. Chihota VN, Grant AD, Fielding K, Ndibongo B, Van Zyl A, Muirhead D, et al. Liquid vs. solid culture for tuberculosis: performance and cost in a resource-constrained setting. The international Journal of Tuberculosis and lung Disease. 2010; 14(8):1024-1031. [Google Scholar][Crossref]
  5. Campelo TA, de Sousa PRC, de Lima Nogueira L, Frota CC, Antas PRZ. Revisiting the methods for detecting Mycobacterium tuberculosis: what has the new millennium brought thus far?. Access Microbiology, 2021, 3(8). [Google Scholar][Crossref]
  6. Clinical and Laboratory Standards Institute. Laboratory detection and identification of mycobacteria; approved guideline-1st edition.CLSI document M48-Clinical and Laboratory Standards Institute, Wayne, PA, 2008. [Google Scholar][Crossref]
  7. Dong Z, Wang QQ, Yu SC, Huang F, Liu JJ, Yao HY, et al. Age-period-cohort analysis of pulmonary tuberculosis reported incidence, China, 2006-2020. Infectious Diseases of Poverty. 2022; 11(04):62-7. [Google Scholar][Crossref]
  8. Escombe A, Huaroto L, Ticona E, Burgos M, Sanchez I, Carrasco L, Farfan E, et al. Tuberculosis transmission risk and infection control in a hospital emergency department in Lima, Peru. The international Journal of Tuberculosis and lung Disease. 2010; 14:1120-1126. [Google Scholar][Crossref]
  9. Gopalaswamy R, Dusthackeer VA, Kannayan S, Subbian S. Extrapulmonary Tuberculosis-An Update on the Diagnosis, Treatment and Drug Resistance. Journal International Journal of Medical and All Body Health Research www.allmedicaljournal.com of Respiration. 2021; 1:141-164. [Google Scholar][Crossref]
  10. Greenwood D. Medical microbiology E-book A guide to microbial infections: Pathogenesis, immunity laboratory diagnosis and control. With Student Consult Online Access. London: Elsevier Health Sciences, 2012. [Google Scholar][Crossref]
  11. Humayun J, Chirenda W, Ye I, Mukeredzi HA. Mujuru and Z. Yang Open Forum Infectious Diseases. 2022; 9(10):512 [Google Scholar][Crossref]
  12. Ibrahim WH, Ghadban W, Khinji A, Yasin R, Soub H, Al-Khal AL, et al. Does pleural tuberculosis disease pattern differ among developed and developing countries? Respiratory medicine. 2005; 99(8):1038-1045. [Google Scholar][Crossref]
  13. Kassaza K, Orikiriza P, Llosa A, Bazira J, Nyehangane D, Page AL, et al. Lowenstein-Jensen selective medium for reducing contamination in Mycobacterium tuberculosis culture. Journal of Clinical Microbiology. 2014; 52(7):26712673. [Google Scholar][Crossref]
  14. Kiani A, Raouf Rahmati R, Bergquist S, Hashtarkhani N, Firouraghi N, Bagheri, et al. BMC Public Health 2021 Vol. 21 Pages 1-20.Kumari, P., Thakur, J.K., Kumar, P., Kumar, R. And Parekh, D., Comparison of LJ Medium and BACTEC MGIT 960 Culture System for the Diagnosis of Tuberculosis. Journal of Clinical & Diagnostic Research, 2020, 14(12). [Google Scholar][Crossref]
  15. Loddenkemper R, Lipman M, Zumla A. Clinical aspects of adult tuberculosis. Cold Spring Harbor Perspectives in Medicine. 2016; 6:a017848. [Google Scholar][Crossref]
  16. Long R, Divangahi M, Schwartzman K. Chapter 2: Transmission and pathogenesis of tuberculosis. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine. 2022; 6:22-32. [Google Scholar][Crossref]
  17. Mathiasen VD, Andersen PH, Johansen IS, Lillebaek T, Wejse C. Clinical features of tuberculous lymphadenitis in a low-incidence country. International Journal of Infectious Diseases. 2020; 98:366-371. [Google Scholar][Crossref]
  18. Mohamad NA, Jusoh NA, Htike ZZ, Win SL. Bacteria identification from microscopic morphology: A survey. International Journal on Soft Computing, Artificial Intelligence and Applications (IJSCAI. 2014; 3:2319-1015. [Google Scholar][Crossref]
  19. Musellim B, Erturan S, Sonmez Duman E, Ongen G. Comparison of extrapulmonary and pulmonary tuberculosis cases: factors influencing the site of reactivation. The International Journal of Tuberculosis and Lung Disease. 2005; 9:1220-1223. [Google Scholar][Crossref]
  20. Ogwang S, Asiimwe BB, Traore H, Mumbowa F, Okwera A. Eisenach KD, et al. Comparison of rapid tests for detection of rifampicin-resistant Mycobacterium tuberculosis in Kampala, Uganda. BMC Infectious Diseases. 2009; 9:1-9. [Google Scholar][Crossref]
  21. Pawełczyk J, Kremer L. The molecular genetics of mycolic acid biosynthesis. Molecular Genetics of Mycobacteria, 2014, 611-631. [Google Scholar][Crossref]
  22. Sharp SE, Lemes M, Sierra SG, Poniecka A, Poppiti Jr RJ. Löwenstein-Jensen media: no longer necessary for mycobacterial isolation. American Journal of Clinical Pathology. 2000; 113(6):770-773. [Google Scholar][Crossref]
  23. Shivakumar S, Padmapriyadarsini C, Chavan A, Paradkar M, Shrinivasa B, Gupte A, et al. Concomitant pulmonary disease is common among patients with extrapulmonary TB. The International Journal of Tuberculosis and Lung Disease. 2022; 26:341-347. [Google Scholar][Crossref]
  24. Sreeramareddy CT, Panduru KV, Verma SC, Joshi HS, Bates MN. Comparison of pulmonary and extrapulmonary tuberculosis in Nepal-a hospital- based retrospective study. BMC Infectious Diseases. 2008; 8:1-7. [Google Scholar][Crossref]
  25. Terracciano E, Amadori F, Zaratti L, Franco E. Tuberculosis: An ever present disease but difficult to prevent. Igiene e sanita pubblica. 2020; 76:59-66. [Google Scholar][Crossref]
  26. Tille P. Bailey & Scott’s Diagnostic Microbiology - E-Book. Elsevier Health Sciences, 2015. [Google Scholar][Crossref]
  27. World Health Organization. Definitions and reporting framework for tuberculosis-2013 revision, 2013. Geneva: WHO [Accessed 9/4/2013]. [Google Scholar][Crossref]
  28. Yang Z, Kong Y, Wilson F, Foxman B, Fowler AH, Marrs CF, et al. Identification of risk factors for extrapulmonary tuberculosis. Clinical Infectious Diseases. 2004; 38:199-205. [Google Scholar][Crossref]

How to Cite

Ali, F. A., Al-Daoody, A. A. K., Hussen, B. M., Salih, I. K., Razaq, I. Y., & Abbas, Z. M. (2023). Impact the prevalence of Mycobacterium tuberculosis in Erbil city. International Journal of Medical and All Body Health Research, 4(1), 54-59.

Ali, Fattma A, et al. "Impact the prevalence of Mycobacterium tuberculosis in Erbil city." International Journal of Medical and All Body Health Research, vol. 4, no. 1, 2023, pp. 54-59.

Ali, F. A., Al-Daoody, A. A. K., Hussen, B. M., Salih, I. K., Razaq, I. Y. and Abbas, Z. M. (2023) 'Impact the prevalence of Mycobacterium tuberculosis in Erbil city', International Journal of Medical and All Body Health Research, 4(1), pp. 54-59.

Ali FA, Al-Daoody AAK, Hussen BM, Salih IK, Razaq IY, Abbas ZM. Impact the prevalence of Mycobacterium tuberculosis in Erbil city. International Journal of Medical and All Body Health Research. 2023;4(1):54-59.

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