International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

Current Issues
     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Unhealthy lifestyles and their deleterious relationship with infections: A Narrative Review

Shashi K Agarwal

US Highway 1, Suite 309, North Brunswick, NJ 08902, USA

Article Information

Volume / Issue2 / 4 (October-December 2021)
Pages54-63
AccessOpen Access

Publication Timeline

  • Received18 November 2021
  • Accepted03 December 2021

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Abstract

Infection morbidity and mortality generate a significant global health burden. Several pandemics throughout human history have caused considerable suffering and killed millions of people. The ongoing Covid-19 pandemic is one such example. Individual lifestyles, if healthy, have been shown to modulate immune function and help fight infection. The five most important lifestyles are diet, obesity, exercise, alcohol consumption, and smoking. A favorable lifestyle or a prudent change result in reducing the risk and severity of infections. These include several viral, bacterial, parasitic, and fungal infections. The medical scientific literature is loaded with large well-done studies that have focused on the individual role of these lifestyles. A direct connection has been identified and verified in most cases. This manuscript provides a narrative review of this lifestyle-infection relationship. The aim is to raise the awareness of health care providers on the significant impact healthy lifestyles can have on infectious diseases. It is hoped that disseminating this data will translate into improved healthcare.

Keywords

infectionssmokinglifestylesexercisealcoholdietobesity

References

  1. Signore A. About inflammation and infection. EJNMMI Res. 2013; 3(1):8. Published 2013 Feb 1. Doi: 10.1186/2191-219X-3-8. [Google Scholar][Crossref]
  2. https://www.cdc.gov/flu/pandemic-resources/1918-pandemic-h1n1.html. [Google Scholar][Crossref]
  3. Thèves C., Biagini P., Crubézy E. The rediscovery of smallpox. Clin. Microbiol. Infect. 2014; 20:210-218. 10.1111/1469-0691.12536. [Google Scholar][Crossref]
  4. https://www.who.int/gho/hiv/en/. [Google Scholar][Crossref]
  5. WHO, Global Health Observatory (GHO) Data. World Health Organization Geneva; Switzerland, 2016. [Google Scholar][Crossref]
  6. Hu T, Li J, Carr M.J, Duchene S, Shi W. The Asian lineage of Zika virus: transmission and evolution in Asia and the Americas. Virol Sin, 2019. [Google Scholar][Crossref]
  7. To KK, Chan JF, Tsang AK, Cheng VC, Yuen KY. Ebola virus disease: A highly fatal infectious disease reemerging in West Africa. Microbes Infect. 2015; 17 (2):84-97. [Google Scholar][Crossref]
  8. Dawson P, Malik MR, Parvez F, Morse SS. What have we learned about Middle East respiratory syndrome coronavirus emergence in humans? A systematic literature review. Vector Borne Zoonotic Dis. 2019; 19(3):174-192. [Google Scholar][Crossref]
  9. https://www.worldometers.info/coronavirus/. [Google Scholar][Crossref]
  10. https://www.healthsystemtracker.org/brief/covid19-and-other-leading-causes-of-death-in-the-us. [Google Scholar][Crossref]
  11. Elezukurtaj S, Greuel S, Ihlow J, et al. Causes of death and comorbidities in hospitalized patients with COVID-19. Sci Rep. 2021; 11: 4263. https://doi.org/10.1038/s41598-021-82862-5. [Google Scholar][Crossref]
  12. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020; 323(13):1239-1242. [Google Scholar][Crossref]
  13. Murray CJL, Lopez AD, Naghavi M, Wang H. GBD International Journal of Medical and all body Health Research www.allmedicaljournal.com 58 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388:1459-544. [Google Scholar][Crossref]
  14. World Health Organization. Global tuberculosis report. Geneva: World Health Organization, 2016. [Google Scholar][Crossref]
  15. World Health Organization. Global tuberculosis report 2019. Geneva: World Health Organization, 2019. [Google Scholar][Crossref]
  16. Rajasingham R, Smith RM, Park BJ, Jarvis JN, Govender NP, Chiller TM, et al. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect Dis. 2017; 17(8):873-881. [Google Scholar][Crossref]
  17. Brown GD, Denning DW, Levitz SM. Tackling human fungal infections. Science. 2012a; 336:647. 10.1126/science.1222236. [Google Scholar][Crossref]
  18. Fisher MC, Gow NAR, Gurr SJ. Tackling emerging fungal threats to animal health, food security and ecosystem resilience. Philos. Trans. R. Soc. B Biol. Sci. 2016; 371:20160332. [Google Scholar][Crossref]
  19. https://www.cdc.gov/malaria/malaria_worldwide/impac t.html. [Google Scholar][Crossref]
  20. https://www.who.int/publications/i/item/WHO-TRS-749. [Google Scholar][Crossref]
  21. Charles A, Janeway J, Medzhitov R. Innate immune recognition.Ann Rev Immunol. 2002; 20:197-216. Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010; 140:805-820. Doi: 10.1016/j.cell.2010.01.022. [Google Scholar][Crossref]
  22. Boehm T. Design principles of adaptive immune systems.Nat Rev Immunol. 2011; 11:307-317. Doi: 10.1038/nri2944. [Google Scholar][Crossref]
  23. Ruggieri A, Anticoli S, D'Ambrosio A, Giordani L, Viora M. The influence of sex and gender on immunity, infection and vaccination. Ann Ist Super Sanita. 2016; 52(2):198-204. Doi: 10.4415/ANN_16_02_11. [Google Scholar][Crossref]
  24. Pepys MB, Hirschfield GM. C-reactive protein: A critical update. J Clin Invest. 2003; 111(12):1805-12. 10.1172/jci200318921. [Google Scholar][Crossref]
  25. Calder PC, et al. A consideration of biomarkers to be used for evaluation of inflammation in human nutritional studies. Br. J Nutr. 2013; 109:S1-S34. [Google Scholar][Crossref]
  26. Imhof A, Fröhlich M, Loewel H, Helbecque N, Woodward M, Amouyel P, et al. Distributions of C-reactive protein measured by high-sensitivity assays in apparently healthy men and women from different populations in Europe. Clin Chem. 2003; 49(4):669-72. 10.1373/49.4.669, [Google Scholar][Crossref]
  27. Villegas R, Xiang YB, Cai H, Elasy T, Cai Q, Zhang X, et al. Lifestyle determinants of C-reactive protein in middle-aged, urban Chinese men. Nutr Metab Cardiovasc Dis NMCD. 2012 ; 22(3):223-30. 10.1016/j.numecd.2010.07.007. [Google Scholar][Crossref]
  28. Mraz M, Haluzik M. The role of adipose tissue immune cells in obesity and low-grade inflammation. J Endocrinol. 2014. 10.1530/JOE-14-0283. [Google Scholar][Crossref]
  29. Darabseh MZ, Maden-Wilkinson TM, Welbourne G, et al. Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation. Sci Rep. 2021; 11(1):12286. Doi: 10.1038/s41598-021-91510-x. [Google Scholar][Crossref]
  30. Della Guardia L, Codella R. Exercise tolls the bell for key mediators of low-grade inflammation in dysmetabolic conditions. Cytokine Growth Factor Rev. 2021; 21:S1359-6101(21)00070-8. Doi: 10.1016/j.cytogfr.2021.09.003. [Google Scholar][Crossref]
  31. Volpato S, Pahor M, Ferrucci L, et al. Relationship of Alcohol Intake With Inflammatory Markers and Plasminogen Activator Inhibitior-1 in Well-Functioning Older Adults. The Health, Aging, and Body Composition Study. Originally published10 Feb Circulation. 2004; 109:607-612. https://doi.org/10.1161/01.CIR.0000109503.13955.00. [Google Scholar][Crossref]
  32. Power Guerra N, Müller L, Pilz K, Glatzel A, Jenderny D, Janowitz D, et al. Dietary-Induced Low-Grade Inflammation in the Liver. Biomedicines. 2020; 98(12):587. Doi: 10.3390/biomedicines8120587. [Google Scholar][Crossref]
  33. Xiao Q, Keadle SK, Hollenbeck AR, Matthews CE. Sleep duration and total and cause-specific mortality in a large US cohort: Interrelationships with physical activity, sedentary behavior, and body mass index. Am. J Epidemiol. 2014; 180:997-1006. Doi: 10.1093/aje/kwu222. [Google Scholar][Crossref]
  34. Ammar A, Brach M, Trabelsi K, Chtourou H, Boukhris O, Masmoudi L, et al. Effects of COVID-19 home confinement on eating behaviour and physical activity: Results of the ECLB-COVID19 international online survey. Nutrients. 2020; 12:1583. Doi: 10.3390/nu12061583. [Google Scholar][Crossref]
  35. Almirall J, Bolíbar I, Serra-Prat M, Roig J, Hospital I, Carandell E, et al. Community-Acquired Pneumonia in Catalan Countries (PACAP) Study Group. New evidence of risk factors for community-acquired pneumonia: a population-based study. Eur Respir J. 2008; 31(6):1274-84. doi: 10.1183/09031936.00095807. [Google Scholar][Crossref]
  36. Hamer M, O’Donovan G, Stamatakis E. Lifestyle risk factors, obesity and infectious disease mortality in the general population: Linkage study of 97,844 adults from England and Scotland. Prev. Med. (Baltim) 2019; 123:65-70. Doi: 10.1016/j.ypmed.2019.03.002. [Google Scholar][Crossref]
  37. Fourati S, et al. Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination. Nat. Commun. 2016; 7:10369. [Google Scholar][Crossref]
  38. Nuorti JP, Butler JC, Farley MM, et al. Cigarette smoking and invasive pneumococcal disease. Active Bacterial Core Surveillance Team. N Engl J Med. 2000; 342:681-9. Gold R. Epidemiology of bacterial meningitis. Infect Dis Clin North Am 1999; 13:515-25 v. [Google Scholar][Crossref]
  39. Baik I, Curhan GC, Rimm EB, Bendich A, Willett WC, Fawzi WW. A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women. Arch Intern Med. 2000; 160(20):3082-3088. Doi: 10.1001/archinte.160.20.3082. [Google Scholar][Crossref]
  40. Nuorti JP, Butler JC, Farley MM, et al. Cigarette smoking and invasive pneumococcal disease. Active Bacterial Core Surveillance Team. N Engl J Med. 2000; 342(10):681-689. doi: 10.1056/nejm200003093421002. [Google Scholar][Crossref]
  41. Almirall J, Serra-Prat M, Bolibar I, Balasso V. Risk Factors for Community-Acquired Pneumonia in Adults: A Systematic Review of Observational Studies. Respiration. 2017; 94(3):299-311. Doi: 10.1159/000479089. [Google Scholar][Crossref]
  42. Sismanlar Eyuboglu T, Aslan AT, Kose M, et al. Passive Smoking and Disease Severity in Childhood Pneumonia Under 5 Years of Age. J Trop Pediatr. 2020; 66(4):412-418. Doi: 10.1093/tropej/fmz081. [Google Scholar][Crossref]
  43. Almirall J, Bolibar I, Serra-Prat M, et al. New evidence International Journal of Medical and all body Health Research www.allmedicaljournal.com 59 of risk factors for community-acquired pneumonia: a population-based study. Eur Respir J. 2008; 31(6):1274-1284. Doi: 10.1183/09031936.00095807. [Google Scholar][Crossref]
  44. Almirall J, Gonzalez CA, Balanzo X, Bolibar I. Proportion of community-acquired pneumonia cases attributable to tobacco smoking. Chest. 1999; 116(2):375-379. doi: 10.1378/chest.116.2.375. [Google Scholar][Crossref]
  45. Hajjeh RA, Conn LA, Stephens DS, et al. Cryptococcosis: population-based multistate active surveillance and risk factors in human immunodeficiency virus-infected persons. Cryptococcal Active Surveillance Group. J Infect Dis. 1999; 179:449-54. [Google Scholar][Crossref]
  46. Murray RL, Britton J, Leonardi-Bee J. Secondhand smoke exposure and the risk of invasive meningococcal disease in children: systematic review and meta-analysis. BMC Public Health. 2012; 12:1062. [Google Scholar][Crossref]
  47. Bergström J. Tobacco smoking and chronic destructive periodontal disease. Odontology. 2004; 92(1):1-8. Doi: 10.1007/s10266-004-0043-4. [Google Scholar][Crossref]
  48. Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally representative, cross-sectional, screening with the C-Urea breath test. BMC Public Health. 2013; 13:1215. doi: 10.1186/1471-2458-13-1215. [Google Scholar][Crossref]
  49. Zhang X, Chen H, Yang G. [Analysis of Helicobacter pylori infection in healthy people] Chinese Journal of Social Medicine. 2017; 34(3):313-315. Doi: 10.3969/j.issn.1673-5625.2017.03.032. [Google Scholar][Crossref]
  50. Chen L, Jia X, Wang S. [Analysis of current status and risk factors of Helicobacter pylori infection in medical examination population in Miyun District, Beijing] Clinical Medicine of China. 2017; 33(10):891-894. Doi: 10.3760/cma.j.issn.1008-6315.2017.10.007. [Google Scholar][Crossref]
  51. Jeyashree K, Kathirvel S, Hd S, Kaur H, Goel S. Smoking cessation interventions for pulmonary tuberculosis treatment outcomes (Review) Cochrane Database Syst Rev. 2016; 1:CD011125. Doi: 10.1002/14651858.CD011125.pub2. [Google Scholar][Crossref]
  52. Leung CC, Yew WW, Chan CK, Chang KC, law WS, Lee SN, et al. Smoking adversely affects treatment response, outcome and relapse in tuberculosis. Eur Respir J. 2015; 45:583-5. [Google Scholar][Crossref]
  53. Wang EY, Arrazola RA, Mathema B, Ahluwalia IB, Mase SR. The impact of smoking on tuberculosis treatment outcomes: a meta-analysis. Int J Tuberc Lung Dis. 2020; 24(2):170-175. Doi: 10.5588/ijtld.19.0002. [Google Scholar][Crossref]
  54. Barr C, Friedmann P, Desjarlais D. Smoking is a significant factor in HIV-related oral candidiasis. J Dent Res. 1998; 77:155. [Google Scholar][Crossref]
  55. Verweij PE, Kerremans JJ, Voss A, Meis JF. Fungal contamination of tobacco and marijuana. JAMA. 2000; 284:2875. [Google Scholar][Crossref]
  56. Pourbaix A, Lafont Rapnouil B, Guéry R, Lanternier F, Lortholary O, Cohen JF. Smoking as a Risk Factor of Invasive Fungal Disease: Systematic Review and Meta-Analysis. Clin Infect Dis. 2020; 71(4):1106-1119. [Google Scholar][Crossref]
  57. Mdege ND, Shah S, Ayo-Yusuf OA, Hakim J, Siddiqi K. Tobacco use among people living with HIV: analysis of data from demographic and health surveys from 28 low-income and middle-income countries. Lancet Glob Health. 2017; 5:e578-92. [Google Scholar][Crossref]
  58. Feldman C, Anderson R. Cigarette smoking and mechanisms of susceptibility to infections of the respiratory tract and other organ systems. J Infect. 2013; 67:169-84. [Google Scholar][Crossref]
  59. Rush B. An Inquiry into the Effects of Ardent Spirits upon the Human Body and Mind: With an Account of the Means of Preventing, and of the Remedies for Curing Them. 6th ed. Cornelius Davis; New York, NY, USA: 1811. (Originally published 1785). [Google Scholar][Crossref]
  60. Szabo G, Saha B. Alcohol's Effect on Host Defense. Alcohol Res. 2015; 37(2):159-70. [Google Scholar][Crossref]
  61. Samokhvalov AV, Irving HM, Rehm J. Alcohol consumption as a risk factor for pneumonia: a systematic review and meta-analysis. Epidemiol Infect 2010; 138:1789-95. 10.1017/S0950268810000774. [Google Scholar][Crossref]
  62. Simou E, Britton J, Leonardi-Bee J. Alcohol and the risk of pneumonia: a systematic review and meta-analysis. BMJ Open. 2018; 8(8):e022344. Published 2018 Aug 22. Doi: 10.1136/bmjopen-2018-022344. [Google Scholar][Crossref]
  63. Imtiaz S, Shield KD, Roerecke M, Samokhvalov AV, Lönnroth K, Rehm J. Alcohol consumption as a risk factor for tuberculosis: Meta-analyses and burden of disease. Eur. Respir. J. 2017; 50:1700216. Doi: 10.1183/13993003.00216-2017. [Google Scholar][Crossref]
  64. Ragan EJ, Kleinman MB, Sweigart B, et al. The impact of alcohol use on tuberculosis treatment outcomes: A systematic review and meta-analysis. Int. J Tuberc. Lung. Dis. 2020; 24:73-82. Doi: 10.5588/ijtld.19.0080. [Google Scholar][Crossref]
  65. GBD. 2016 Lower Respiratory Infections Collaborators Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Infect. Dis. 2018; 18:1191-1210. Doi: 10.1016/S1473-3099(18)30310-4. [Google Scholar][Crossref]
  66. Dos Santos DT, Arroyo LH, Alves YM, Alves LS, Berra TZ, Crispim JA, et al. Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil. Trop. Med. Health. 2021; 49:31. Doi: 10.1186/s41182-021-00320-4. [Google Scholar][Crossref]
  67. Workie MG, Aycheh MW, Birhanu MY, Tsegaye TB. Treatment interruption among drug-susceptible pulmonary tuberculosis patients in Southern Ethiopia. Patient Prefer. Adherence. 2021; 15:1143-1151. Doi: 10.2147/PPA.S307091. [Google Scholar][Crossref]
  68. Cords O, Martinez L, Warren JL, et al. Incidence and prevalence of tuberculosis in incarcerated populations: A systematic review and meta-analysis. Lancet Public Health. 2021; 6:e300-e308. Doi: 10.1016/S2468-2667(21)00025-6. [Google Scholar][Crossref]
  69. Friedman LN, Sullivan GM, Bevilaqua RP, Loscos R. Tuberculosis screening in alcoholics and drug addicts. Am. Rev. Respir. Dis. 1987; 136:1188-1192. Doi: 10.1164/ajrccm/136.5.1188. [Google Scholar][Crossref]
  70. Bhattacharya R, Shuhart MC. Hepatitis C. and alcohol: interactions, outcomes, and implications. J Clin Gastroenterol. 2003; 36(3):242-52. Doi: 10.1097/00004836-200303000-00012. [Google Scholar][Crossref]
  71. Gitto S, Micco L, Conti F, Andreone P, Bernardi M. Alcohol and viral hepatitis: a mini-review. Dig Liver Dis. 2009; 41(1):67-70. doi: 10.1016/j.dld.2008.05.009. [Google Scholar][Crossref]
  72. Szabo G. Consequences of alcohol consumption on host defence. Alcohol Alcohol. 1999; 34:830-841. Doi: 10.1093/alcalc/34.6.830. [Google Scholar][Crossref]
  73. Neuman MG. Cytokines-central factors in alcoholic liver disease. Alcohol Res. Health. 2003; 27:307-316. [Google Scholar][Crossref]
  74. Happel KI, Nelson S. Alcohol, immunosuppression, and International Journal of Medical and all body Health Research www.allmedicaljournal.com 60 the lung. Proc. Am. Thorac. Soc. 2005; 2:428-432. Doi: 10.1513/pats.200507-065JS. [Google Scholar][Crossref]
  75. Tu Testino G. Are Patients With Alcohol Use Disorders at Increased Risk for Covid-19 Infection? Alcohol Alcohol. 2020; 55(4):344-346. Doi: 10.1093/alcalc/agaa037. [Google Scholar][Crossref]
  76. Gauthier TW, Drews-Botsch C, Falek A, Coles C, Brown LA. Maternal alcohol abuse and neonatal infection. Alcohol Clin Exp Res. 2005; 29(6):1035-43. Doi: 10.1097/01.alc.0000167956.28160.5e. [Google Scholar][Crossref]
  77. Szabo G, Mandrekar P. A recent perspective on alcohol, immunity, and host defense. Alcohol. Clin. Exp. Res. 2009; 33:220-232. Doi: 10.1111/j.1530-0277.2008.00842.x. [Google Scholar][Crossref]
  78. Huttunen R, Syrjänen J. Obesity and the risk and outcome of infection. Int J Obes (Lond). 2013; 37(3):333-40. Doi: 10.1038/ijo.2012.62. [Google Scholar][Crossref]
  79. Huttunen R, Karppelin M, Syrjänen J. Obesity and nosocomial infections. J Hosp Infect. 2013; 85(1):8-16. Doi: 10.1016/j.jhin.2013.06.012. [Google Scholar][Crossref]
  80. Słabuszewska-Jóźwiak A, Szymański JK, Jóźwiak Ł, Sarecka-Hujar B. A Systematic Review and Meta-Analysis of Wound Complications after a Caesarean Section in Obese Women. J Clin Med. 2021; 10(4):675. Doi: 10.3390/jcm10040675. [Google Scholar][Crossref]
  81. Chen TP, Yu HC, Lin TH, Wang YH, Chang YC. Association between obesity and chronic periodontitis: A nationwide population-based cohort study in Taiwan. Medicine (Baltimore). 2021; 100(41):e27506. Doi: 10.1097/MD.0000000000027506. [Google Scholar][Crossref]
  82. Grupper M, Nicolau DP. Obesity and skin and soft tissue infections: how to optimize antimicrobial usage for prevention and treatment? Curr Opin Infect Dis. 2017; 30(2):180-191. Doi: 10.1097/QCO.0000000000000356. [Google Scholar][Crossref]
  83. Albashir AAD. The potential impacts of obesity on COVID-19. Clin Med (Lond). 2020; 20(4):e109-e113. Doi: 10.7861/clinmed.2020-0239. [Google Scholar][Crossref]
  84. Yang J, Hu J, Zhu C. Obesity aggravates COVID-19: A systematic review and meta-analysis. J Med Virol. 2021; 93(1):257-261. Doi: 10.1002/jmv.26237. [Google Scholar][Crossref]
  85. Townsend MJ, Kyle TK, Stanford FC. Commentary: COVID‐19 and obesity: exploring biologic vulnerabilities, structural disparities, and weight stigma. Metabolism 2020; 110:154316. doi:10.1016/j.metabol.2020.154316. [Google Scholar][Crossref]
  86. Dhurandhar NV, Bailey D, Thomas D. Interaction of obesity and infections. Obes Rev. 2015; 16(12):1017-29. Doi: 10.1111/obr.12320. [Google Scholar][Crossref]
  87. Popkin BM, Du S, Green WD, et al. Individuals with obesity and COVID‐19: A global perspective on the epidemiology and biological relationships. Obes Rev 2020; 21:e13128. doi:10.1111/obr.13128. [Google Scholar][Crossref]
  88. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol. 2005; 115(5):911-9. Quiz 920. doi: 10.1016/j.jaci.2005.02.023. [Google Scholar][Crossref]
  89. Mikhailova SV, Ivanoshchuk DE. Innate-Immunity Genes in Obesity. J Pers Med. 2021; 11(11):1201. Doi: 10.3390/jpm11111201. [Google Scholar][Crossref]
  90. https://healthyliving.azcentral.com/acsm-definition-cardiovascular-exercise-18723.html. [Google Scholar][Crossref]
  91. Warburton DER, Bredin SSD. Health benefits of physical activity: a systematic review of current systematic reviews. Curr Opin Cardiol 2017; 32(5):541-56.10.1097/HCO.0000000000000437). [Google Scholar][Crossref]
  92. Pape K, Ryttergaard L, Rotevatn TA, Nielsen BJ, Torp-Pedersen C, Overgaard C, et al. Leisure-time physical activity and the risk of suspected bacterial infections. Med Sci Sports Exerc 2016 ; 48(9):1737-44.10.1249/MSS.0000000000000953. [Google Scholar][Crossref]
  93. Kostka T, Berthouze SE, Lacour J, Bonnefoy M. The symptomatology of upper respiratory tract infections and exercise in elderly people. Med Sci Sports Exerc. 2000; 32(1):46-51.10.1097/00005768-200001000-00008. [Google Scholar][Crossref]
  94. Leveille SG, Gray S, LaCroix AZ, Ferrucci L, Black DJ, Guralnik JM. Physical inactivity and smoking increase risk for serious infections in older women. J Am Geriatr Soc. 2000; 48(12):1582-8.10.1111/j.1532-5415.2000.tb03867.x. [Google Scholar][Crossref]
  95. Romaniszyn D, Pobiega M, Wojkowska-Mach J, Chmielarczyk A, Gryglewska B, Adamski P, et al. The general status of patients and limited physical activity as risk factors of methicillin-resistant Staphylococcus aureus occurrence in long-term care facilities residents in Krakow, Poland. BMC Infect Dis . 2014; 14:271.10.1186/1471-2334-14-271. [Google Scholar][Crossref]
  96. Baik I, Curhan GC, Rimm EB, Bendich A, Willett WC, Fawzi WW. A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women. Arch Intern Med . 2000; 160(20):3082-8.10.1001/archinte.160.20.3082, [Google Scholar][Crossref]
  97. Nieman DC, Pedersen BK. Exercise and immune function. Recent developments. Sports Med. 1999; 27(2):73-80. doi: 10.2165/00007256-199927020-00001. [Google Scholar][Crossref]
  98. Calabrese L, Neiman DC. Exercise, infection and rheumatic diseases: what do we know?. RMD Open. 2021; 7(2):e001644. Doi: 10.1136/rmdopen-2021-001644. [Google Scholar][Crossref]
  99. Barrett B, Hayney MS, Muller D, Rakel D, Brown R, Zgierska AE. Meditation or exercise for preventing acute respiratory infection (MEPARI-2): A randomized controlled trial. PLoS ONE. 2018; 13(6):1-20. [Google Scholar][Crossref]
  100. Nieman DC, Pedersen BK. Exercise and immune function. Recent developments. Sports Med. 1999; 27(2):73-80. doi: 10.2165/00007256-199927020-00001. [Google Scholar][Crossref]
  101. Nieman DC, Henson DA, Austin MD, et al. Upper respiratory tract infection is reduced in physically fit and active adults. Br J Sports Med 2011; 45:987-92. 10.1136/bjsm.2010.077875. [Google Scholar][Crossref]
  102. Chastin SFM, Abaraogu U, Bourgois JG, et al. Effects of Regular Physical Activity on the Immune System, Vaccination and Risk of Community -Acquired Infectious Disease in the General Population: Systematic Review and Meta-Analysis. Sports Med. 2021; 51(8):1673-1686. Doi: 10.1007/s40279-021-01466-1. [Google Scholar][Crossref]
  103. Hamer M, O'Donovan G, Stamatakis E. Lifestyle risk factors, obesity and infectious disease mortality in the general population: linkage study of 97,844 adults from England and Scotland. Prev Med. 2019; 123:65-70. 10.1016/j.ypmed.2019.03.002. [Google Scholar][Crossref]
  104. Simpson RJ, Campbell JP, Gleeson M, et al. Can exercise affect immune function to increase susceptibility to infection? Exerc Immunol Rev. 2020; 26:8-22. [Google Scholar][Crossref]
  105. Filgueira TO, Castoldi A, Santos LER, et al. The relevance of a physical active lifestyle and physical fitness on immune defense: mitigating disease burden, with focus on COVID-19 consequences. Front Immunol. 2021; 12:587146. 10.3389/fimmu.2021.587146. [Google Scholar][Crossref]
  106. Valenzuela PL, Simpson RJ, Castillo-García A, et al. International Journal of Medical and all body Health Research www.allmedicaljournal.com 61 Physical activity: a coadjuvant treatment to COVID-19 vaccination? Brain Behav Immun. 2021; 94:00105-7. 10.1016/j.bbi.2021.03.003. [Google Scholar][Crossref]
  107. Hamer M, Kivimäki M, Gale CR, et al. Lifestyle risk factors, inflammatory mechanisms, and COVID-19 hospitalization: a community-based cohort study of 387,109 adults in UK. Brain Behav Immun. 2020; 87:184-7. 10.1016/j.bbi.2020.05.059. [Google Scholar][Crossref]
  108. O’Brien K, Tynan Anne-Marie, Nixon S, Glazier RH. Effectiveness of aerobic exercise for adults living with HIV: systematic review and meta-analysis using the Cochrane Collaboration Protocol, 2016. Doi: 10.1186/s12879-016-1478-2. [Google Scholar][Crossref]
  109. Muñoz-Torrico M, Rendon A, Centis R, et al. Is there a rationale for pulmonary rehabilitation following Victoria M. Ruta et al. 16 successful chemotherapy for tuberculosis? J Bras Pneumol. 2016; 42(5):374-85. DOI: 10.1590/S1806- 37562016000000226. [Google Scholar][Crossref]
  110. Gleeson M. Exercise and immune function. J. Appl. Physiol. 2007; 103:693-699. 10.1152/japplphysiol.00008.2007. [Google Scholar][Crossref]
  111. Ekblom B, Ekblom O, Malm C. Infectious episodes before and after a marathon race. Scand J Med Sci. Sports. 2006; 16(4):287-93. [Google Scholar][Crossref]
  112. Heath GW, Ford ES, Craven TE, Macera CA, Jackson KL, Pate RR. Exercise and the incidence of upper respiratory tract infections. Med Sci Sports Exerc. 1991; 23(2):152-7. [Google Scholar][Crossref]
  113. Nieman DC, Johanssen LM, Lee JW, Arabatzis K. Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fitness. 1990; 30(3):316-28. [Google Scholar][Crossref]
  114. Nieman DC, Pedersen BK. Exercise and immune function. Recent developments. Sports Med. 1999; 27(2):73-80. Doi: 10.2165/00007256-199927020-00001. [Google Scholar][Crossref]
  115. Andrade A, Dominski FH, Pereira ML, de Liz CM, Buonanno G. Infection risk in gyms during physical exercise. Environ Sci Pollut Res Int. 2018; 25(20):19675-19686. doi: 10.1007/s11356-018-1822-8. [Google Scholar][Crossref]
  116. Hoeffler DF. Swimmers' itch (cercarial dermatitis). Cutis. 1977; 19(4):461-5, 467. [Google Scholar][Crossref]
  117. Bull FC, Al-Ansari SS, Biddle S, Borodulin K, Buman MP, Cardon G, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020; 54:1451-1462. Doi: 10.1136/bjsports-2020-102955. [Google Scholar][Crossref]
  118. Barrett B, Hayney MS, Muller D, Rakel D, Brown R, Zgierska AE. Meditation or exercise for preventing acute respiratory infection (MEPARI-2): A randomized controlled trial. PLoS ONE. 2018; 13(6):1-20. [Google Scholar][Crossref]
  119. Lee DH, de Rezende LFM, Eluf-Neto J, Wu K, Tabung FK, Giovannucci EL. Association of type and intensity of physical activity with plasma biomarkers of inflammation and insulin response. Int J Cancer. 2019; 145:360-369. Doi: 10.1002/ijc.32111. [Google Scholar][Crossref]
  120. Beck MA, Levander OA. Dietary oxidative stress and the potentiation of viral infection. Annu Rev Nutr. 1998; 18(1):93-116.; Beck MA. The influence of antioxidant nutrients on viral infection. Nutr Rev. 2009; 56(1):S140-6. [Google Scholar][Crossref]
  121. Caccialanza R, Laviano A, Lobascio F, et al. Early nutritional supplementation in non-critically ill patients hospitalized for the 2019 novel coronavirus disease (COVID-19): rationale and feasibility of a shared pragmatic protocol. Nutrition. 2020; 74:110835. [Google Scholar][Crossref]
  122. Alkhatib A, Tuomilehto J. Lifestyle Diabetes Prevention. In: Huhtaniemi I, Martini L, editors. Encyclopaedia of Endocrine Diseases. Volume 1. Elsevier; Amsterdam, the Netherlands, 2019, 148-159. [Google Scholar][Crossref]
  123. López-Varela S, González-Gross M, Marcos A. Functional foods and the immune system: A review. Eur. J Clin. Nutr. 2002; 56(Suppl. 3):S29-S33. Doi: 10.1038/sj.ejcn.1601481. [Google Scholar][Crossref]
  124. Childs CE, Calder PC, Miles EA. Diet and Immune Function. Nutrients. 2019; 11:1933. Doi: 10.3390/nu11081933. [Google Scholar][Crossref]
  125. Silverio R, Caetano Gonçalves D, Andrade MF, Seelaender M. Coronavirus Disease 2019 (COVID-19) and Nutritional Status: The Missing Link? Adv. Nutr. 2020, 1-11. doi: 10.1093/advances/nmaa125. [Google Scholar][Crossref]
  126. Childs CE, Calder PC, Miles EA. Diet and Immune Function. Nutrients. 2019; 11:1933. Doi: 10.3390/nu11081933. [Google Scholar][Crossref]
  127. Silverio R, Caetano Gonçalves D, Andrade MF, Seelaender M. Coronavirus Disease 2019 (COVID-19) and Nutritional Status: The Missing Link? Adv. Nutr, 2020, 1-11. doi: 10.1093/advances/nmaa125. [Google Scholar][Crossref]
  128. Morais AHA, Aquino JS, da Silva-Maia JK, Vale SHL, Maciel BLL, Passos TS. Nutritional status, diet and viral respiratory infections: perspectives for severe acute respiratory syndrome coronavirus 2. Br J Nutr. 2021; 125(8):851-862. Doi: 10.1017/S0007114520003311. [Google Scholar][Crossref]
  129. Shivappa N., Bonaccio M, Hebert JR, et al. Moli-sani study Investigators. Association of proinflammatory diet with low-grade inflammation: Results from the Moli-sani study. Nutrition. 2018; 54:182-188. Doi: 10.1016/j.nut.2018.04.004. [Google Scholar][Crossref]
  130. Cena H, Chieppa M. Coronavirus Disease (COVID-19-SARS-CoV-2) and Nutrition: Is Infection in Italy Suggesting a Connection? Front. Immunol, 2020 Doi: 10.3389/fimmu.2020.00944. [Google Scholar][Crossref]
  131. USDA USDoA. Profiling Food Consumption in America. Washington, DC: Book AF, 2002. [Google Scholar][Crossref]
  132. Lopez-Garcia E, Schulze MB, Fung TT, Meigs JB, Rifai N, Manson JE. Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction. Am J Clin Nutr 80:1029-1035. [Google Scholar][Crossref]
  133. Kalinski P. Regulation of immune responses by prostaglandin E2. J Immunol. 2012; 188:21-28. [Google Scholar][Crossref]
  134. Tabarkiewicz J, Pogoda K, Karczmarczyk A, Pozarowski P, Giannopoulos K. The Role of IL-17 and Th17 Lymphocytes in Autoimmune Diseases. Arch Immunol Ther Exp (Warsz). 2015; 63(6):435-449. Doi: 10.1007/s00005-015-0344-z. [Google Scholar][Crossref]
  135. Calder PC. Fatty acids and inflammation: the cutting edge between food and pharma. Eur J Pharmacol. 2011; 668(Suppl 1):S50-S58. [Google Scholar][Crossref]
  136. Kim K, Jung N, Lee K, Choi J, Kim S, Jun J, et al. Dietary omega-3 polyunsaturated fatty acids attenuate hepatic ischemia/reperfusion injury in rats by modulating toll-like receptor recruitment into lipid rafts. Clin Nutr. 2013; 32:855-862. [Google Scholar][Crossref]
  137. Liu J, Hu S, Cui Y, Sun MK, Xie F, Zhang Q, et al. Saturated fatty acids up-regulate COX-2 expression in prostate epithelial cells via toll-like receptor 4/NF-kappa B signaling. Inflammation. 2013; 37(2):467-477. [Google Scholar][Crossref]
  138. Frommer KW, Schaffler A, Rehart S, Lehr A, Muller-International Journal of Medical and all body Health Research www.allmedicaljournal.com 62 Ladner U, Neumann E. Free fatty acids: potential proinflammatory mediators in rheumatic diseases. Ann Rheum Dis. 2013; 0:1-8. [Google Scholar][Crossref]
  139. Calder PC. Fatty acids and immune function: relevance to inflammatory bowel diseases. Int Rev Immunol. 2009; 28:506-534. [Google Scholar][Crossref]
  140. Innis SM. Dietary lipids in early development: relevance to obesity, immune and inflammatory disorders. Curr Opin Endocrinol Diabetes Obes. 2007; 14:359-364. [Google Scholar][Crossref]
  141. Kuhnt K, Wagner A, Kraft J, Basu S, Jahreis G. Dietary supplementation with 11trans- and 12trans-18:1 and oxidative stress in humans. Am J Clin Nutr. 2006; 84:981-988. [Google Scholar][Crossref]
  142. Sanchez A, Reeser JL, Lau HS, et al. Role of sugars in human neutrophilic phagocytosis. Am J Clin Nutr. 1973; 26:1180-1184. [Google Scholar][Crossref]
  143. Sorensen LB, Raben A, Stender S, Astrup A. Effect of sucrose on inflammatory markers in overweight humans. Am J Clin Nutr. 2005; 82:421-427. [Google Scholar][Crossref]
  144. Kleinewietfeld M, Manzel A, Titze J, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 2013; 496:518-522. [Google Scholar][Crossref]
  145. Wu C, Yosef N, Thalhamer T, et al. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature. 2013; 496:513-517. [Google Scholar][Crossref]
  146. Maggini S, Pierre A, Calder PC. Immune Function and Micronutrient Requirements Change over the Life Course. Nutrients. 2018; 10:1531. Doi: 10.3390/nu10101531 [Google Scholar][Crossref]
  147. Kuo SM. The interplay between fiber and the intestinal microbiome in the inflammatory response. Adv Nutr. 2013; 4:16-28. [Google Scholar][Crossref]
  148. D'Alessandro A, Lampignano L, De Pergola G. Mediterranean diet pyramid: a proposal for Italian people. A systematic review of prospective studies to derive serving sizes. Nutrients. 2019; 11(6):1296. [Google Scholar][Crossref]
  149. Davis C, Bryan J, Hodgson J, Murphy K. Definition of the Mediterranean diet: a literature review. Nutrients. 2015; 7(11):9139-53. [Google Scholar][Crossref]
  150. Weylandt KH, Chiu CY, Gomolka B, Waechter SF, Wiedenmann B. Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. Prostaglandins Other Lipid Mediat. 2012; 97:73-82. [Google Scholar][Crossref]
  151. Calder PC, Carr AC, Gombart AF, Eggersdorfer M. Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients. 2020; 12:1181. Doi: 10.3390/nu12041181. [Google Scholar][Crossref]
  152. García-Burgos M, Moreno-Fernández J, Alférez MJM, Díaz-Castro J, López-Aliaga I. New perspectives in fermented dairy products and their health relevance. J. Funct. Foods. 2020; 72:104059. [Google Scholar][Crossref]
  153. Calder PC. Nutrition, immunity and COVID-19. BMJ Nutr. Prev. Health. 2020; 3:e000085. Doi: 10.1136/bmjnph-2020-000085. [Google Scholar][Crossref]
  154. Ahluwalia N, Andreeva VA, Kesse-Guyot E, Hercberg S. Dietary patterns, inflammation and the metabolic syndrome. Diabetes Metab. 2013; 39(2):99-110. Doi: 10.1016/j.diabet.2012.08.007. [Google Scholar][Crossref]
  155. Jayawardena R. Enhancing immunity in viral infections, with special emphasis on COVID-19: a review. Diabetes, Metab Syndrome: Clin Res Rev. 2020; 14(4):367-382. [Google Scholar][Crossref]
  156. Maggini S, Pierre A, Calder PC. Immune Function and Micronutrient Requirements Change over the Life Course. Nutrients. 2018; 10:1531. Doi: 10.3390/nu10101531. [Google Scholar][Crossref]
  157. Iddir M, Brito A, Dingeo G, et al. Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis. Nutrients. 2020; 12:1562. Doi: 10.3390/nu12061562. [Google Scholar][Crossref]
  158. Vanherwegen AS, Gysemans C, Mathieu C. Regulation of Immune Function by Vitamin D and Its Use in Diseases of Immunity. Endocrinol Metab Clin North Am 2017; 46(4):1061-94. 10.1016/j.ecl.2017.07.010. [Google Scholar][Crossref]
  159. Pilz S, Zitterman A, Trummer C, Schwetz V, Lerchbaum E, Keppel M, et al. Vitamin D Testing and Treatment: A Narrative Review of Current Evidence. Endocr Connect. 2019; 8(2):R27-43. 10.1530/EC-18-0432. [Google Scholar][Crossref]
  160. Akbar MR, Wibowo A, Pranata R, Setiabudiawan B. Low Serum 25-Hydroxyvitamin D (Vitamin D) Level Is Associated With Susceptibility to COVID-19, Severity, and Mortality: A Systematic Review and Meta-Analysis. Front Nutr 2021; 8:660420. 10.3389/fnut.2021.660420. [Google Scholar][Crossref]
  161. Mrityunjaya M, Pavithra V, Neelam R, Janhavi P, Halami PM, Ravindra PV. Immune -Boosting, Antioxidant and Anti-inflammatory Food Supplements Targeting Pathogenesis of COVID-19. Front Immunol. 2020; 11:570122. Doi: 10.3389/fimmu.2020.570122. [Google Scholar][Crossref]
  162. Van Driel ML, Beller EM, Thielemans E, Deckx L, Price-Haywood E, Clark J, De Sutter AI. Oral vitamin C supplements to prevent and treat acuteupper respiratory tract infections. Cochrane Database Syst Rev. 2019: CD013292. Doi: 10.1002/14651858.CD013292. [Google Scholar][Crossref]
  163. Micronutrient Information Center Immunity in Depth. [(Accessed on 17 April 2018)]; Available online: http://lpi.oregonstate.edu/mic/health-disease/immunity. [Google Scholar][Crossref]
  164. Haryanto B, Suksmasari T, Wintergerst E, Maggini S. Multivitamin supplementation supports immune function and ameliorates conditions triggered by reduced air quality. Vitam. Miner. 2015; 4:1-15. [Google Scholar][Crossref]
  165. Saeed F, Nadeem M, Ahmed R, Nadeem M, Arshad M, Ullah A. Studying the impact of nutritional immunology underlying the modulation of immune responses by nutritional compounds- review. Food Agric. Immunol. 2016; 27:205-229. Doi: 10.1080/09540105.2015.1079600. [Google Scholar][Crossref]
  166. Alpert P. The role of vitamins and minerals on the immune system. Home Health Care Manag. Pract. 2017; 29:199-202. Doi: 10.1177/1084822317713300. [Google Scholar][Crossref]
  167. Taneri PE, Gómez‑Ochoa SA, Llanaj E, et al. Anemia and iron metabolism in COVID‑19: A systematic review and meta‑analysis. Eur. J Epidemiol. 2020; 35:763-773. doi: 10.1007/s10654-020-00678-5, [Google Scholar][Crossref]
  168. Cruza V, Macedo Rogero M, Noel Keane K, Curi R, Newsholme P. Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. Nutrients. 2018; 10:1564. Doi: 10.3390/nu10111564. [Google Scholar][Crossref]
  169. McCarthy MS, Martindale RG. Immunonutrition in Critical Illness: What Is the Role? Nutr. Clin. Pract. 2018: 33. Doi: 10.1002/ncp.10102. [Google Scholar][Crossref]
  170. Trujillo-Mayol I, Guerra-Valle M, Casas-Forero N, et al. Western Dietary Pattern Antioxidant Intakes and Oxidative Stress: Importance during the SARS-CoV-2/COVID-19 Pandemic. Adv Nutr. 2021; 12(3):670-681. Doi: 10.1093/advances/nmaa171.International Journal of Medical and all body Health Research www.allmedicaljournal.com 63 [Google Scholar][Crossref]
  171. Zhou K, Lansang MC. Diabetes Mellitus and Infections. 2021 Mar 16. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000. [Google Scholar][Crossref]
  172. Rook GA. 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: darwinian medicine and the ‘hygiene’ or ‘old friends’ hypothesis. Clin Exp Immunol. 2010; 160:70-79. [Google Scholar][Crossref]

How to Cite

Agarwal, S. K. (2021). Unhealthy lifestyles and their deleterious relationship with infections: A Narrative Review. International Journal of Medical and All Body Health Research, 2(4), 54-63. https://doi.org/10.54660/Ijmabhr.2021.2.4.2

Agarwal, Shashi K. "Unhealthy lifestyles and their deleterious relationship with infections: A Narrative Review." International Journal of Medical and All Body Health Research, vol. 2, no. 4, 2021, pp. 54-63. https://doi.org/10.54660/Ijmabhr.2021.2.4.2.

Agarwal, S. K. (2021) 'Unhealthy lifestyles and their deleterious relationship with infections: A Narrative Review', International Journal of Medical and All Body Health Research, 2(4), pp. 54-63. doi: 10.54660/Ijmabhr.2021.2.4.2.

Agarwal SK. Unhealthy lifestyles and their deleterious relationship with infections: A Narrative Review. International Journal of Medical and All Body Health Research. 2021;2(4):54-63. doi:10.54660/Ijmabhr.2021.2.4.2

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