Abstract

The diagnosis along with management of Breast cancer(BC) are going through a prototype switch from the one size fitting all towards the period of individualized medicine. With the advances in diagnosis that is inclusive of sophisticated methods like molecular imaging in addition to genomic expression profile aid in enhancement of tumor characteristics to get unraveled. With these diagnostics, in combination with the newer surgical strategies in addition to radiation therapy cause a strategy that is inclusive of multiple disciplines cooperating with each other for reduction of recurrence to the utmost minimum. Here we conducted a review utilizing search engine pub-med, google scholar; web of science; embrace; Cochrane review library utilizing the MeSH terms like surgery; presence or absence of estrogen receptor(ER);progesterone receptor(PR); human epidermal growth factor receptor (HER2),; chemotherapy; triple negative breast cancer(TNBC); endocrine therapy; metastases; radio therapy; imaging modalities; causes of TNBC; drug resistance; prognosis; markers for TNBC; effective tamoxifen; negative neo adjuvant chemotherapy; gene markers; role of microRNAs, from 1980’s till august 2021.We found a total of 442800 articles out of which we selected 86 articles for this chapter on update on breast cancer management. No meta-analysis was done. Further we have tried to explore a lot of modes by which TNBC treatment success can get escalated inclusive of the newer utilization of H2S pathway in cancer as well as mode by which it might work. Further with the escalated 5 yr survival along with advances in ovarian tissue cryopreservation oocyte cryopreservation prior to chemotherapy as well as radiotherapy one can consider ovarian tissue transplantation in such cases. With BCS an attempt at cosmetic surgery aids in women leading a more normal life. Thus we have tried to comprehensively detail all these features.