Based on the 2013 Riskesdas data, the Yogyakarta Special Region Province has the highest prevalence rate of DM, therefore it is important to give attention to the management of DM patients in Yogyakarta. One of the complications experienced by diabetes mellitus patients is the occurrence of diabetic foot ulcers. Patient adherence to all aspects of DM therapy is very important to achieve optimal therapeutic results, especially if the patient has complications of diabetic ulcers. This study aims to see the relationship between adherence to drug use and characteristics in DM patients with diabetic ulcers. This research applied a correlative analytic with a cross-sectional design. The study was conducted at five wound care clinics in DIY Province. The number of respondents in the study was 31 people with the sampling technique using accidental sampling. Data were collected using an adherence questionnaire instrument in DM patients. Respondents in this study were 48.4% male and 51.6% female. Most age groups are between 51-60 years (51.6%). The longest time span to suffer from diabetes was 10-15 years (45.2%). Respondents had the most injuries with ulcer degree 1 as much as 35.5% and 54.8% of respondents did not comply with the use of drugs. Based on the statistical tests conducted, it was found that there was a relationship between the length of suffering from diabetes and adherence to take medication (p=0.000) and there was a relationship between the length of suffering from diabetes and the degree of ulcers (p=0.030), there is no relationship between drug adherence to the degree of ulcers (p=0.936). There is a relationship between the length of suffering from DM with medication adherence and the degree of ulcers. There is no relationship between medication adherence and the degree of ulcers.