Background: According to the literature described, antiseptics are chemical agents whose function is to inhibit or destroy the growth of microorganisms in living tissues, among the most widely used antiseptics is chlorhexidine gluconate, which is widely used in hospitals due to its characteristics and properties. different applications, which make a powerful agent to prevent infection at the wound site.rnMethodology: A narrative review was carried out in which databases such as pubmed, science direct, scielo, academic Google, among others, were used to search for articles, these were taken from indexed journals in first and second languages. As keywords, the descriptors DECS and MeSH, antiseptics, chlorhexidine gluconate, wounds, infection were used.rnResults: Several studies have demonstrated the effectiveness of chlorhexidine gluconate, in preventing infections in wounds, and various application techniques have been used, such as compresses impregnated with the antiseptic, washing in the preoperative site before the incision, showers or baths, among others. All demonstrating the high efficiency in reducing bacterial colonies.