Evaluation of Anti-Parkinsons And Monoaminooxidase-B(Mao_B) Inhibitory Properties of Polygonum Cuspidatam In Male Sprague Dawley Rats
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Abstract
Background: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuronal loss, oxidative stress, and elevated monoamine oxidase-B (MAO-B) activity. Polygonum cuspidatum, rich in antioxidant phytochemicals, has potential neuroprotective effects.
Objective: To evaluate the anti-Parkinsonian and MAO-B inhibitory properties of Polygonum cuspidatum ethanolic extract (PCEE) in a 6-hydroxydopamine (6-OHDA) induced rat model of PD.
Methods: Rats were divided into five groups: Sham control, 6-OHDA control, 6-OHDA + L-DOPA (6 mg/kg), and 6-OHDA + PCEE (200 and 500 mg/kg). Behavioral assessments (rotarod, catalepsy, and apomorphine-induced rotations) and biochemical analyses (MAO-B activity, dopamine levels via HPLC, lipid peroxidation, catalase, and glutathione levels) were performed.
Results: 6-OHDA induced significant motor deficits, elevated MAO-B activity, reduced dopamine, increased lipid peroxidation, and decreased antioxidant enzyme activities. PCEE treatment produced a dose-dependent improvement in motor behavior and significantly inhibited MAO-B activity. Additionally, PCEE restored dopamine levels and antioxidant status, reducing oxidative damage comparable to L-DOPA.
Conclusion: Polygonum cuspidatum ethanolic extract exhibits potent anti-Parkinsonian effects through MAO-B inhibition and antioxidant mechanisms, suggesting its potential as a natural therapeutic agent for PD management.
How to Cite
Srivani, M., Kumari, M. M., & Rani, I. V. (2026). Evaluation of Anti-Parkinsons And Monoaminooxidase-B(Mao_B) Inhibitory Properties of Polygonum Cuspidatam In Male Sprague Dawley Rats. International Journal of Medical and All Body Health Research, 7(1), 91-99. https://doi.org/10.54660/IJMBHR.2026.7.1.91-99
Srivani, Meda, et al. "Evaluation of Anti-Parkinsons And Monoaminooxidase-B(Mao_B) Inhibitory Properties of Polygonum Cuspidatam In Male Sprague Dawley Rats." International Journal of Medical and All Body Health Research, vol. 7, no. 1, 2026, pp. 91-99. https://doi.org/10.54660/IJMBHR.2026.7.1.91-99.
Srivani, M., Kumari, M. M. and Rani, I. V. (2026) 'Evaluation of Anti-Parkinsons And Monoaminooxidase-B(Mao_B) Inhibitory Properties of Polygonum Cuspidatam In Male Sprague Dawley Rats', International Journal of Medical and All Body Health Research, 7(1), pp. 91-99. doi: 10.54660/IJMBHR.2026.7.1.91-99.
Srivani M, Kumari MM, Rani IV. Evaluation of Anti-Parkinsons And Monoaminooxidase-B(Mao_B) Inhibitory Properties of Polygonum Cuspidatam In Male Sprague Dawley Rats. International Journal of Medical and All Body Health Research. 2026;7(1):91-99. doi:10.54660/IJMBHR.2026.7.1.91-99
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