Abstract

The monogenic disorders are associated with the same increased risk for atherosclerosis in different populations. However, the frequency with which polygenic hypercholesterolemia occurs in different populations varies widely, as does the incidence of coronary artery disease. Populations with a high mean plasma cholesterol concentration have a high rate of coronary artery disease. It is believed that the difference between populations in the frequency of hypercholesterolemia reflects one or more environmental factors, the most obvious being diet and, in particular, the saturated fat content of the diet.rnStudy design: Single blind placebo controlled studyrnPlace and duration of study: National hospital Lahore from January to June 2017. rnMaterial and Method: Written consent was taken from all patients. This consent was already approved by ETHICS COMMITTEE of the hospital. These patients were divided in two groups. Group-I (n=30) was on placebo (capsules containing grinded wheat shell only) and group-II (n=30) was advised to take 200 grams raw ladyfinger in divided doses for three months. Baseline fasting blood sugar (FBS) and lipid profile was determined at day-0, day-30, day-60, and at the end of research period ie; day-90. Serum LDL-cholesterol was calculated by Friedwald formula10 (LDL-Cholesterol = Total Cholesterol-(Triglycerides/5 +HDL-Cholesterol). Glucometer made by Roch pharma serial No: CE 0123 was used for estimation of FBS.rnResults: For statistical analysis SPSS version 2010 was used. SD and ±SEM was determined from mean of the pre and post treatment values. Paired ‘t’ test was applied to see p-value of the tested parameters. P-value >0.05 was considered as non significant change, <0.01 as significant and <0.001 as highly significant change in the tested parameter.rnConclusion: It was concluded from the research study that ladyfingers or Okra can reduce LDL cholesterol and Fasting Blood Sugar (FBS) of patient suffering from DM type-2 and hyperlipidemia significantly when this vegetable is used for specific time period.