Abstract

Microspheres play a very important role as particulate drug delivery system because of their small size and other efficient properties. Microspheres are characteristically free flowing solid powders, which consist of proteins or synthetic polymer, which are biodegradable in nature. The present study aimed to formulate and evaluate Pregabal in microspheres. Ionotropic gelation technique was employed for microsphere preparation using different ratios of ethyl cellulose polymer and drug. Prepared microspheres were evaluated for drug entrapment efficiency, micromeritic characters and In vitro drug release. The particle size of all the formulations were ranged between 152.2 to 142.9 µm. The entrapment efficiency was ranged between 78.95 to 82.14 %. Stability studies showed almost negligible changes in particle size, entrapment efficiency and drug release throughout the study period.