The objective of present study was to develop matrix type transdermal therapeutic systems of Metoprolol tartrate using various such as Sodium alginate and HPMC polymers as matrix formers. Results revealed that prepared patches showed good physical characteristics and no drug-polymer interaction was observed. The in vitro release study revealed that F3 formulation showed maximum release in 8 hrs. Formulation F3 was subjected for accelerated stability studies. The F3 formulation was found to be stable as there was no drastic change in the Physico-chemical properties of the patches, which was also confirmed by FTIR. Thus, conclusion can be made that stable transdermal patch of Metoprolol tartrate has been developed. F3 formulation showed highest cumulative percentage drug release of 93.97 % were obtained during in vitro drug release studies after 8 hrs. The predominant release mechanism of drug through the fabricated matrices was believed to be by diffusion mechanism. Based upon the in vitro dissolution data the F3 formulation was concluded as optimized formulation.