The most harmful of the numerous common staphylococcal bacteria is Staphylococcus aureus, a gram-positive organism that causes a wide range of clinical diseases, including skin infections, bacteremia, endocarditis, pneumonia, and food poisoning. A variety of S. aureus virulence factors help to establish infection by encouraging tissue attachment, tissue invasion, and invasion of the host immune response. S. aureus is a pathogenic bacteria that, although being a commensal in both humans and animals, has the ability to produce several toxic and enzymes that allow it to penetrate the host  body and cause a variety of infections, some of which may be regarded as life-threatening diseases. Virulence factors provide mechanisms for bacterial growth support and disease-causing processes. Numerous virulence traits that S. aureus possesses enable it to success as a pathogen. Additionally through the secretion of proteins, S. aureus can activate host zymogens, which in turn can target certain defense components. Secreted proteins can also prevent neutrophils or the complement system's proteases from destroying pathogens, which raises the possibility that S. aurous will survive. The review aims to highlight S. aureus virulence factors and secretion protein that help the bacteria to survive from host immune system.