Alzheimer's disease (AD), as a degenerative neurodegenerative disease that has a growing trend causes the exacerbation of the infectious disease of COVID-19, or on the contrary, the infection of Covid-19 can aggravate the symptoms of AD and the severe form of COVID-19 appears. There are several mechanisms for the worsening of AD condition after COVID-19. It is reasonable to assume that COVID-19 has a more severe impact on patients with comorbidities, including those with AD. As such, individuals with AD should take additional preventive measures to avoid contracting COVID-19, as they are at a heightened risk of developing severe symptoms of the disease, which could result in increased mortality rates.