Blood serves as a vehicle for transmission of blood-borne pathogens including hepatitis viruses and hemoparasities. In Taraba State, screening of blood for blood-borne pathogens does not fulfill the standard protocols and screening for malaria parasites is not practiced. This study was to determine the immunological evaluation of Hepatitis B Virus, Hepatitis C Virus and Plasmodium co-infection profile among individuals in Wukari. One hundred (100) venous blood samples was obtained from individuals age between 15 to 74 years randomly using a dry sterile syringe and needle; the blood is withdrawn from a suitable vein in the arm and the blood sample was slowly ejected into sample tube (EDTA container) and standard microbiological techniques were observed. The result denotes an overall prevalence of HBV, HCV and malaria parasites to be 15%, 6.0% and 2% respectively. It also shows in terms of sex and age groups that HBV has the highest prevalence within age group of 25-34, 4 (4.0%) for male and 25-34, 4 (4.0%) for female, while, HCV has the least prevalence within the age group of 15-24, 1 (10%) and 25-34, 1 (10%), for male and age group of 15-24, 1 (10%), 25-34, 1 (10%) and 35-44, 1 (10%) for females. The male population was the only one tested positive for malaria parasite from the age group of 15-24, 2 (2.0%). There was no co-infection of Hepatitis B virus, Hepatitis C and malaria, despite having prevalence of 15%, 6% and 2% respectively. The research on its own has shown that in order to reduce HBV, HCV and plasmodium co-infection, mass immunization of adults and antiviral drugs should be provided for those that are infected, while HBV, HCV and plasmodium co-infections screening programs should be instituted in all levels of institutions, communities and societies in the North East region, Taraba state in particular and the country in general to reduce the prevalence rate and level of transmission of hepatitis virus. This study also has added to the puddle of knowledge in this area of research.