Abstract

Background: Treatment of pregnant women with epilepsy is a challenge as the benefit of the treatment has to be weighed against the adverse fetal and maternal effects of the drug.rnObjective: To determine the malformation risk of fetus exposed to antiseizure medication during pregnancy and to assess other fetal outcomes including pregnancy losses, growth retardation in fetus. rnMethods: This is a retrospective observational study from patient records. Both mother and infant data from records were retrospectively collected and interpreted. Any disparity and missing information was collected by directly contacting the concerned patients.rnResults: A total of 137 pregnancies in women with epilepsy were studied. The incidence of major congenital malformation was 6.8%. There were 13 pregnancy losses (9.4%) and 12 preterm deliveries (87.6%)rnConclusion: The observations of adverse fetal outcomes were comparable to the larger studies conducted. More importance to women with epilepsy and their treatment should be given. There is a need for larger and comparative regional studies in pregnant females with epilepsy.