International Journal of Medical and All Body Health Research  |  e-ISSN: 2582-8940  |  Double-Blind Peer Review  |  Open Access  |  CC BY-NC-SA 4.0

Current Issues
     2026:7/4

International Journal of Medical and All Body Health Research

e-ISSN: 2582-8940 | Open Access

Pregnancy outcome in women with epilepsy: A pilot study in Oman

Vinitha Leelamani

Specialist Neurologist, Sohar hospital, Sultanate of Oman

Article Information

Volume / Issue3 / 1 (January-March 2022)
Pages45-47
AccessOpen Access

Publication Timeline

  • Received15 February 2021
  • Accepted01 March 2022

Full Text (PDF)

Open Access - Free to Download

Download Full Article (PDF) JATS XML

Abstract

Background: Treatment of pregnant women with epilepsy is a challenge as the benefit of the treatment has to be weighed against the adverse fetal and maternal effects of the drug.rnObjective: To determine the malformation risk of fetus exposed to antiseizure medication during pregnancy and to assess other fetal outcomes including pregnancy losses, growth retardation in fetus. rnMethods: This is a retrospective observational study from patient records. Both mother and infant data from records were retrospectively collected and interpreted. Any disparity and missing information was collected by directly contacting the concerned patients.rnResults: A total of 137 pregnancies in women with epilepsy were studied. The incidence of major congenital malformation was 6.8%. There were 13 pregnancy losses (9.4%) and 12 preterm deliveries (87.6%)rnConclusion: The observations of adverse fetal outcomes were comparable to the larger studies conducted. More importance to women with epilepsy and their treatment should be given. There is a need for larger and comparative regional studies in pregnant females with epilepsy.

Keywords

Background: Treatment of pregnant women with epilepsy

References

  1. Holmes LB. Need for inclusion and exclusion criteria for the structural abnormalities recorded in children born from exposed pregnancies. Teratology. 1999; 59(1):1-2. doi: 10.1002/(SICI)1096-9926(199901)59:1<1::AID-TERA1>3.0.CO;2-L. PMID: 9988874. [Google Scholar][Crossref]
  2. Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Perucca E, et al. EURAP Study Group. Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. Lancet Neurol. 2018; 17(6):530-538. doi: 10.1016/S1474-4422(18)30107-8. Epub 2018 Apr 18. PMID: 29680205. [Google Scholar][Crossref]
  3. Hernández-Díaz S, Smith CR, Shen A, Mittendorf R, Hauser WA, Yerby M, et al. North American AED Pregnancy Registry; North American AED Pregnancy Registry. Comparative safety of antiepileptic drugs during pregnancy. Neurology. 2012; 78(21):1692-9. Doi: 10.1212/WNL.0b013e3182574f39. Epub 2012 May 2. PMID: 22551726. [Google Scholar][Crossref]
  4. Campbell E, Kennedy F, Russell A, Smithson WH, Parsons L, Morrison PJ, et al. Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. J Neurol Neurosurg Psychiatry. 2014; 85(9):1029-34. Doi: 10.1136/jnnp-2013-306318. Epub 2014. PMID: 24444855. [Google Scholar][Crossref]
  5. Meador KJ, Baker GA, Browning N, et al. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. Lancet Neurol. 2013; 12(3):244-252. doi:10.1016/S1474-4422(12)70323-X [Google Scholar][Crossref]
  6. Vossler DG. Comparative Risk of Major Congenital Malformations with 8 Different Antiepileptic Drugs: A Prospective Cohort Study of the EURAP Registry. Epilepsy Curr. 2019; 19(2):83-85. Doi: 10.1177/1535759719835353 [Google Scholar][Crossref]
  7. Jentink J, Loane MA, Dolk H, Barisic I, Garne E, Morris JK, et al. EUROCAT Antiepileptic Study Working Group. Valproic acid monotherapy in pregnancy and major congenital malformations. N Engl J Med. 2010; 362(23):2185-93. Doi: 10.1056/NEJMoa0907328. PMID: 20558369. [Google Scholar][Crossref]
  8. Pierre Blotière, Fanny Raguideau, Alain Weill, Elisabeth Elefant, Isabelle Perthus, Véronique Goulet, et al. Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs . Neurology. 2019; 93(2):e167e180 DOI: 10.1212/WNL.0000000000007696 [Google Scholar][Crossref]
  9. Hunt S, Russell A, Smithson WH, Parsons L, Robertson I, Waddell R, et al. UK Epilepsy and Pregnancy Register. Topiramate in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register. Neurology. 2008; 71(4):272-6. Doi: 10.1212/01.wnl.0000318293.28278.33.PMID: 18645165. [Google Scholar][Crossref]
  10. Jentink J, Dolk H, Loane MA, Morris JK, Wellesley D, Garne E, et al. Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study. BMJ. 2010; 341:c6581. [Google Scholar][Crossref]
  11. Alsaadi T, Kassie S, Farook F, Nasreddine W, Wani S, Saleh B. Antiseizure drugs use during pregnancy and congenital malformations: A retrospective review from the United Arab Emirates. Epilepsy Res. 2020; 159:106259. doi: 10.1016/j.eplepsyres.2019.106259. Epub 2019 Dec 20. PMID: 31901526. [Google Scholar][Crossref]
  12. Mawhinney E, Craig J, Morrow J, Russell A, Smithson WH, Parsons L, et al. Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. Neurology. 2013; 80(4):400-5. Doi: 10.1212/WNL.0b013e31827f0874. Epub 2013 Jan 9. Erratum in: Neurology. 2013; 80(7):691. PMID: 23303847. [Google Scholar][Crossref]
  13. Thomas SV, Syam U, Devi JS. Predictors of seizures during pregnancy in women with epilepsy. Epilepsia. 2012; 53(5):e85-8. doi: 10.1111/j.1528 -1167.2012.03439.x. Epub 2012 Mar 16. PMID: 22429269. [Google Scholar][Crossref]
  14. Vajda FJE, Graham JE, Hitchcock AA, Lander CM, O'Brien TJ, Eadie MJ. Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register. Seizure. 2019; 65:6-11. doi: 10.1016/j.seizure.2018.12.006. Epub 2018 Dec 19. PMID: 30593875. [Google Scholar][Crossref]
  15. Peller AJ, Westgate MN, Holmes LB. Trends in congenital malformations, 1974-1999: effect of prenatal diagnosis and elective termination. Obstet Gynecol. 2004; 104(5Pt 1):957-64. Doi: 10.1097/01.AOG.0000142718.53380.8f.PMID: 15516385. [Google Scholar][Crossref]

How to Cite

Leelamani, V. (2022). Pregnancy outcome in women with epilepsy: A pilot study in Oman. International Journal of Medical and All Body Health Research, 3(1), 45-47.

Leelamani, Vinitha. "Pregnancy outcome in women with epilepsy: A pilot study in Oman." International Journal of Medical and All Body Health Research, vol. 3, no. 1, 2022, pp. 45-47.

Leelamani, V. (2022) 'Pregnancy outcome in women with epilepsy: A pilot study in Oman', International Journal of Medical and All Body Health Research, 3(1), pp. 45-47.

Leelamani V. Pregnancy outcome in women with epilepsy: A pilot study in Oman. International Journal of Medical and All Body Health Research. 2022;3(1):45-47.

Similar Articles

Share

Find this Article on

Google Scholar Semantic Scholar OpenAlex ResearchGate BASE

A newly published article may take a few days to appear on these services.