Drug nanosuspension emerged as a solution for delivering hydrophobic drugs. Pharmaceutical Nanosuspension is defined as very finely biphasic, colloid, dispersed solid drug particle in a aqueous solution. Two factor that limit the efficacy of pharmaceutical product are solubility and bioavailability.This problem are overcome by using nanosuspensions in place of traditional dosage form. This review describes various methods for preparation of nanosuspension, characteristics of drugs,application and potential benefits. Techniques such as homogenization, milling precipitation etc found to have a great potential to solve various issues in delivery of API. Nanosuspensions can be used for targeted delivery as their surface properties and in vivo behavior can easily be altered.Thus nanosuspensions help to increase solubility and bioavailability of drugs.