Aim & Objective: Wound closure is an essential component of any surgical procedure. This study aims to evaluate the efficacy of N-butyl cyanoacrylate in extraoral maxillofacial incisions with respect to wound dehiscence, infection, necrosis, and time required for closure. Materials and Methods: Thirty-five patients undergoing extraoral maxillofacial procedures with incisions less than 6 cm were treated and wound closure using N-butyl cyanoacrylate (ENDOCRYL®) was done. Clinical outcomes were assessed postoperatively. Statistical analysis was performed using descriptive statistics. Results: The mean time required for wound closure was 31.3 ± 4.7 seconds. Postoperative infection and necrosis were observed in 2.9% cases, while wound dehiscence was observed in 8.6% cases. Conclusion: N-butyl cyanoacrylate is an effective and reliable method for closure of extraoral maxillofacial incisions, demonstrating minimal rates of wound dehiscence and infection along with significantly reduced operative time. It can be considered a safe alternative to conventional suturing techniques.