Background: The infection called Molluscum contagiosum (MC) is caused by a virus called a poxvirus and is characterized by small dome-shaped bumps on a child’s skin. MC is often treated with various treatments (some have been around for a long time) however, the best possible options will be safe, effective, easy to apply and tolerated well by children. This study was performed to compare the efficacy and safety of the use of topical 10% Potassium Hydrate (KOH) to the use of intralesional measles, mumps and rubella (MMR) vaccination when using those two treatments for caregivers who have a child with Molluscum contagiosum. Methods: This prospective study was conducted on 60 children (1-12 years old) with clinically diagnosed molluscum contagiosum and randomly assigned them to two groups of 30. Group A had topical 10% KOH applied, while Group B was treated using intralesional MMR vaccine. Following up for two years, including six months after treatment, the researchers assessed and compared the two groups on treatment response, lesion clearance rate, recurrence rate, and adverse effects associated with the respective treatments. Results: A complete clearance of the lesions occurred in 86.7% of the patients who received the MMR treatment; however, only 70% had total lesion clearance in the KOH group (p