Background: liver iron overload in hemoglobinopathy population with repeated blood transfusion is an important morbidity warranting the evaluation of a non-invasive method of liver iron quantification. MR T2* / R2* relaxometry technique has shown promising results in this domain.  Aim of Study: this prospective cross sectional study aim to show the value of MR T2*/R2* relaxometry technique, in assessment of hepatic iron overload in a sample of hemoglobinopathy population at our hospital on repeated blood transfusion therapy in South of Iraq (Basra city).  Patients and Methods: a total of 70 anaemic patients, mean age 21 years  ( range : 1055 years old) patients with hemoglobinopathy who had received repeated blood transfusions and on chelation therapy at time of examination, underwent MRI T2* / R2* relaxometry study. The corresponding iron overload was calculated for each patient, then correlation between MRI relaxometry study and serum ferritin level using correlation coefficient was done.  Results: at the time of the study, serum ferritin levels ranged between 297 and 7324 ng/l ( mean 1958  ng/l).based on the calculated liver iron concentration (LIC) values show that 37.1% of the patients had moderate level of LIC, the highest prevalence of severe LIC was seen significantly in patients using DFO drug(25%) and in those diagnosed with thalassemia major (16.2%), no significant association between LIC and splenectomy. Strong negative correlation was detected between LIC and T2*, Perfect positive correlation between LIC and R2* and moderate positive correlation between LIC and S. ferritin. No significant correlation between LIC and age.  In conclusion, MRI R2*/T2* provides a non-invasive, precise, and repeatable method for measuring tissue iron content. The treatment of tissue iron excess should be improved by the widespread use of this approach, enabling early chelation intensification & monitoring of iron level & response to treatment  Conclusion: In conclusion, MRI R2* provides a non-invasive, precise, and repeatable method for measuring hepatic tissue iron content  Recommendation: that. MRI is effective in management of hemoglobinopathy so,repeat liver MRI for all patients who have LIC > 7mg/g DW liver (every 6 months,or 1year depending on guidelines and Cardiac MRI is required for all patient to exclude cardiac iron deposition.