IJMABHR International Journal of Medical and All Body Health ResearchIJMABHR 2582-8940 Anfo Publication House 414 10.54660/IJMBHR.2025.6.4.133-136 Total Sialic Acid, Lipid Associated Sialic Acid and Lipid Profile in Patients with Thyroid Dysfunction AbdulhussainMohammad D MajidAli Y MuhiSamer A DawoodAl-Hussein M MBchB, Msc, PhD Clinical Biochemistry Department of Pharmacy, Ishtar Medical Institute, 10002 Baghdad, Iraq MBchB, Msc, FICMS, Chemical pathology, Department of Pharmacy, Ishtar Medical Institute, 10002 Baghdad, Iraq MBchB, Department of Pharmacy, Ishtar Medical Institute, 10002 Baghdad, Iraq 09122025 6 4 133 136 13102025 15112025 CC BY-NC-SA 4.0

Total sialic acid refers to a family of compounds derived from nine unsubstituted carbon chain neuraminic acids. Sialic acid plays a role in normal thyroid function and is altered in thyroid diseases, further more lipids have been shown to change in thyroid disorders. The current study was conducted to evaluate the level of total sialic acid, lipid associated sialic acid, total cholesterol, triglyceride, HDL – cholesterol and LDL cholesterol in sera of patients with thyroid dysfunction to find the relation between those parameters and thyroid diseases. The study sample was composed of 58 patients with newly diagnosed hypothyroidism, 62 patients with newly diagnosed hyperthyroidism and 60 healthy individuals as pathological control who are attending Al-Yarmouk Teaching Hospital/ Baghdad during the period between October 2020 to April 2022.Total sialic acid, lipid associated sialic acid, T3, T4, TSH, cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol tests were done for the groups of the sample.  Results showed that there was significant increase in Total sialic acid, total cholesterol, triglyceride, HDL-cholesterol and LDL —cholesterol in patients with hypothyroidism while there was no significant change in lipid associated sialic acid in patients with hyperthyroidism and hypothyroidism. The study concluded that thyroid dysfunctions alter the levels of lipid profile and sialic acid.  

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