Background: Medication administration is one of the most common functions of the practice of nursing. With the growing number of patients with special health care needs, many health institutes found that the number of patients needing medications at hospitals is increasing. With extended release preparations, many schools are seeing a trend away from mid-day dosing. More non-oral medications are being administrated, adding to the complexity of the task of medication administration (NASNPS, 2023).  Objectives: The study aims to identify the anesthetists’ skills concerning the ten rights of medications administration at Al-Imam Al-Hussein Medical City and Al-Hindiya Teaching Hospital in Holy Kerbala’a City. Methodology: A Descriptive quantitative approach design is conducted to evaluate anesthetists’ clinical knowledge concerning the ten rights of medications administration. The study has started on 1st of January, 2024 and ended on 25th of May, 2024. The study instrument consisted of two parts; part one deals with the characteristics of the sample which of age, gender, level of education, years of experience as an anesthetist, and participation in education course concerning the ten rights of medications administration. Part two deals with anesthetists’ clinical knowledge concerning the ten rights of medications administration which was 10 items. The validity of instrument was obtained from 5 experts in specialty. The data analysis was done by using SPSS program version 23. the statistical methods which used in present study is descriptive and inferential statistics.  Results: the findings of present study about anesthetists' clinical knowledge concerning the ten rights of medications administration revealed that implement observations was 67.75%, while not implement observations was 32.25%.  Conclusions: the study showed that anesthetists’ have good skill toward the ten rights of medications administration.  Recommendations: The researcher recommends ensure to apply the present study on all anesthetists in Holy Kerbala’a City Hospitals so as to achieve an evidence-based knowledge concerning the ten rights of medications administration.