IJMABHR International Journal of Medical and All Body Health ResearchIJMABHR 2582-8940 Anfo Publication House 376 10.54660/IJMBHR.2025.6.3.141-146 Comparison of Efficacy of Ondansetron and Palanosetron for Prevention of Post Spinal Shivering During Lower Limb Surgeries: A Randomized Controlled Trial JavedWamiq GoelSharad SharmaShailja BhardwajAbhishek SehgalAnkur Sakshi Post Graduate Resident, Department of Anaesthesia and Critical Care, Saraswathi Institute of Medical Sciences, Pilkhuwa, Hapur, Uttar Pradesh, India Professor, Department of Anaesthesia and Critical Care, Saraswathi Institute of Medical Sciences, Pilkhuwa, Hapur, Uttar Pradesh, India Professor & HOD, Department of Anaesthesia and Critical Care, Saraswathi Institute of Medical Sciences, Pilkhuwa, Hapur, Uttar Pradesh, India Assistant Professor, Department of Anaesthesia and Critical Care, Saraswathi Institute of Medical Sciences, Pilkhuwa, Hapur, Uttar Pradesh, India PG Resident, Department of Anaesthesia and Critical Care, Saraswathi Institute of Medical Sciences, Pilkhuwa, Hapur, Uttar Pradesh, India 27072025 6 3 141 146 16062025 19072025 CC BY-NC-SA 4.0

Post-spinal shivering is a common and distressing complication following spinal anesthesia, occurring in 40-70% of patients undergoing lower limb surgeries. This randomized, double-blind, placebo-controlled study aimed to compare the efficacy of ondansetron and palanosetron in preventing post-spinal shivering in patients undergoing lower limb surgeries under spinal anesthesia. A total of 180 patients aged 18-65 years, ASA physical status I-II, scheduled for elective lower limb surgeries were randomly allocated into three groups of 60 patients each: Group O received ondansetron 4 mg intravenously, Group P received palanosetron 0.075 mg/kg intravenously, and Group C received normal saline as placebo, all administered 15 minutes before spinal anesthesia. The primary outcome was the incidence of post-spinal shivering during the first 2 hours postoperatively. Secondary outcomes included severity of shivering, time to onset, hemodynamic parameters, and adverse effects. The incidence of post-spinal shivering was significantly lower in both treatment groups compared to placebo: Group O (18.3%), Group P (13.3%) versus Group C (63.3%) (p

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