References

IJMABHR

International Journal of Medical and All Body Health Research

IJMABHR

2582-8940

Anfo Publication House

366

10.54660/IJMBHR.2025.6.3.82-88

Comparative Evaluation of Intrathecal Clonidine and Nalbuphine as an Adjuvant to Hyperbaric Ropivacaine in Subarachnoid Block

Sehgal

Ankur

Jagar

Keshav Dev

Gupta

Lokesh Kumar

Sharma

Shailja

Goel

Sharad

Vaid

Nikhil

Madhrey

Manish

1Post Graduate Resident, Department of Anaesthesia and Critical Care, Saraswathi Institute of Medical Sciences, Pilkhuwa, Hapur, Uttar Pradesh, India 2Associate Professor, Department of Anaesthesia and Critical Care, Saraswathi Institute of Medical Sciences, Pilkhuwa, Hapur, Uttar Pradesh, India 3Professor, Department of Anaesthesia and Critical Care, Saraswathi Institute of Medical Sciences, Pilkhuwa, Hapur, Uttar Pradesh, India 4HOD & Professor, Department of Anaesthesia and Critical Care, Saraswathi Institute of Medical Sciences, Pilkhuwa, Hapur, Uttar Pradesh, India 5Assistant Professor, Department of Anaesthesia and Critical Care, Saraswathi Institute of Medical Sciences, Pilkhuwa, Hapur, Uttar Pradesh, India 6Senior Resident, Department of Anaesthesia and Critical Care, Saraswathi Institute of Medical Sciences, Pilkhuwa, Hapur, Uttar Pradesh, India

21072025

6 3 82 88 10062025 11072025

CC BY-NC-SA 4.0

Subarachnoid block is a widely used anesthetic technique for lower abdominal and lower limb surgeries. Adding adjuvants to local anesthetics enhances block quality and prolongs postoperative analgesia. This prospective, randomized, double-blind study compared the efficacy of intrathecal clonidine versus nalbuphine as adjuvants to hyperbaric ropivacaine. Ninety patients undergoing lower limb orthopedic surgery were randomly allocated into three groups (n=30 each): Group R received 15mg hyperbaric ropivacaine 0.75% alone, Group RC received ropivacaine plus 30μg clonidine, and Group RN received ropivacaine plus 0.8mg nalbuphine. Primary outcomes included onset and duration of sensory and motor block. Secondary outcomes comprised duration of analgesia, hemodynamic parameters, and adverse effects. Both adjuvant groups showed significantly faster onset of sensory block (RC: 4.2±0.8min, RN: 4.5±0.9min) compared to control (5.8±1.1min) (p

ClonidineHyperbaric ropivacaineIntrathecal adjuvantsNalbuphineSpinal anesthesiaSubarachnoid block

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