The total methanol residue, n-hexane and chloroform extracts from Zingiber zerumbet Linn rhizomes have been evaluated for α-glucosidase inhibitory activity in an attempt to identify potential active ingredients in natural products. The results showed that the chloroform extract inhibited α-glucosidase more effectively than the positive control acarbose, with an IC50 value of 127.8 µg/mL. This antioxidant activity of the crude extract; fractional extracts including: n-hexane extract, chloroform extract, and methanol extract of from Zingiber zerumbet has been investigated using DPPH assay. The results showed that the crude chloroform extract exhibited good antioxidant activities with IC50 value of 2.09 µg/mL.