Tobacco use remains a leading cause of preventable morbidity and mortality worldwide, necessitating comprehensive, multisectoral strategies for effective control. This paper explores the integration of evidence-based approaches across various sectors—including healthcare, policy, education, economics, and technology—to strengthen tobacco control measures. The study examines the role of global frameworks such as the WHO Framework Convention on Tobacco Control (WHO FCTC) and the MPOWER policy package in guiding national and local interventions. Key strategies analyzed include taxation and pricing policies, stringent advertising bans, graphic health warnings, smoking cessation programs, and community-based awareness campaigns. Additionally, the paper highlights the importance of leveraging digital technologies, such as artificial intelligence, big data analytics, and mobile health (mHealth) applications, in enhancing public health interventions. Special attention is given to the socioeconomic and demographic factors influencing tobacco consumption patterns, emphasizing the need for equity-focused policies that address disparities in access to cessation support. Furthermore, cross-sector collaboration among governments, public health institutions, non-governmental organizations, and private entities is explored as a critical enabler of sustainable tobacco control. The study synthesizes empirical evidence from global case studies to demonstrate the effectiveness of integrated tobacco control strategies in reducing smoking prevalence, improving health outcomes, and mitigating economic burdens. It also discusses challenges, such as industry interference, enforcement gaps, and cultural resistance, and proposes policy recommendations for strengthening governance, monitoring, and evaluation mechanisms. The findings underscore that a holistic, evidence-driven, and multisectoral approach is essential to achieving long-term public health benefits and advancing global tobacco control objectives.