IJMABHR International Journal of Medical and All Body Health ResearchIJMABHR 2582-8940 Anfo Publication House 221 Formulation and evaluation of gastroretentive floating microspheres of nimodipine KhathunMaimuna RaghupathiP ReddyK Aniketh AkhtarShamin HossainMd Zishan Asst Professor, Department of Pharmacology, Sree Dattha Institute of Pharmacy Sheriguda (V), Ibrahimpatnam (M) Ranga Reddy, Telangana, India Department of Pharmaceutics, Sree Dattha Institute of Pharmacy, Sagar Road, Sheriguda, Ibrahimpatnam, Telangana, India 2024 5 2 26 30 08032024 10042024 CC BY-NC-SA 4.0

The objective of the present work was to formulate floating hollow microspheres of Nimodipine which is soluble and shows better absorption in gastric pH. Microspheres were prepared by emulsion solvent diffusion technique. Using various such as ethyl cellulose, carbopol 934, eudragit and sodium alginate polymers. The formulations were evaluated for micromeritic properties, buoyancy, % yield, entrapment efficiency and in vitro studies. They were characterized by FT-IR. FT-IR and studies indicated that there was no interaction between the drug and polymers. SEM photographs showed the outer surface of microspheres was smooth and dense where as internal surface was porous which helped to prolong floating to increase residence time in stomach. The results showed that floating microspheres could be successfully prepared with better yield. Results showed larger the particle size, longer was the floating time. In vitro drug release studies showed controlled release of Nimodipine for over 8 h. From the results it can be concluded that gastric floating hollow microspheres can be successfully used for the delivery of Nimodipine to control the blood pressure. 

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