Sepsis with Multiorgan dysfunction syndrome (MODS) is a common cause of Intensive Care Unit (ICU) mortality and morbidity. The primary cause; infectious or non-infectious, triggers an uncontrollable inflammatory response. Sepsis can be reversed, but as sepsis progresses to severe sepsis and septic shock the mortality rate substantially increases. The diagnosis of sepsis relies on overt symptoms of systemic illness causing a change in the vital parameters of the patient as well as indication of infection through microbial cultures and serology. Various clinical biochemical and hematological parameters in septic patients serve as indicators of organ dysfunction and hence can be used to define the prognosis in a patient with sepsis. In our study, though mean APACHE II score was high among non survivors than survivors (23.28 v/s 18.75), it was of just suggestive significance (p=0.068+). In this study, extensive study of SOFA score was done from day 1 to the last day. The SOFA score on day 1 was high among non survivors and survivors which was statistically significant (10.17 v/s 7.94, p=0.014). However, the most significant difference was observed on day 3. The SOFA score was very high among non survivors as compared to survivors which was statistically very significant (13.42 v/s 6.84, p