Different types of drug delivery systems are intended to deliver therapeutic agents to the appropriate site of interest to get desired pharmacological effect. In the field of drug delivery, the advancement of nanotechnology helps to develop novel dosage forms like proniosomes. They are dry formulation of water-soluble carrier particles that are coated with surfactant. They are rehydrated to form niosomal dispersion immediately before use on agitation in hot aqueous media within minutes. Proniosomes are physically stable during the storage and transport. Drug encapsulated in the vesicular structure of proniosomes prolong the existence of drug in the systematic circulation and enhances the penetration into target tissue and reduce toxicity. This article reviews provesicular drug delivery systems with a focus on composition, preparation, the mechanism of drug delivery, encapsulation of the drug into provesicles and characterization techniques.